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Immunology

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51
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18067
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4105
National Ranking
91

Overview

Volker Brinkmann is a researcher affiliated with Novartis (Switzerland) based in Switzerland. Their work spans several fields, primarily focusing on medicine, biochemistry, genetics, and molecular biology, along with immunology and microbiology.

The scientist has contributed extensively to the study of immune response mechanisms, molecular biology, and infectious diseases. Key areas of research include invertebrate immune response mechanisms, neutrophil and oxidative mechanisms, insect symbiosis and bacterial influences, tuberculosis research, cancer cell metastasis, and blood disorders.

Notable recent publications by Volker Brinkmann include:

  • Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia, 2021, Nature Cell Biology
  • Epithelial response to IFN-γ promotes SARS-CoV-2 infection, 2021, EMBO Molecular Medicine
  • Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming, 2022, Nature Communications
  • EGF and BMPs Govern Differentiation and Patterning in Human Gastric Glands, 2021, Gastroenterology
  • Histone H3 clipping is a novel signature of human neutrophil extracellular traps, 2022, eLife

Frequent co-authors in their work include:

  • Christian Goosmann (12 collaborations)
  • Hans-Joachim Mollenkopf (6 collaborations)
  • Thomas F. Meyer (6 collaborations)
  • Cindrilla Chumduri (5 collaborations)
  • Rajendra Kumar Gurumurthy (5 collaborations)

Volker Brinkmann's research has appeared in several publication venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, mBio, The Journal of Immunology, and Nature Cell Biology.

The expert's main scientific fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Subfields of particular focus are:

  • Immunology
  • Molecular Biology
  • Insect Science
  • Oncology
  • Infectious Diseases

Main research topics covered in their work are:

  • Invertebrate Immune Response Mechanisms
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Insect Utilization and Effects
  • Insect symbiosis and bacterial influences
  • Tuberculosis Research and Epidemiology
  • Cancer Cells and Metastasis
  • Blood disorders and treatments

Best Publications

  • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

    Mehrdad Matloubian;Charles G. Lo;Guy Cinamon;Matthew J. Lesneski

  • Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

    Volker Brinkmann;Andreas Billich;Thomas Baumruker;Peter Heining

  • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

    Gabriele Weitz-Schmidt;Karl Welzenbach;Volker Brinkmann;Tetsji Kamata

  • Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.

    Volker Brinkmann

  • Dynamic T cell migration program provides resident memory within intestinal epithelium

    David Masopust;Daniel Choo;Vaiva Vezys;E. John Wherry

  • FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

    Volker Brinkmann;Jason G. Cyster;Timothy Hla

  • FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

    Volker Brinkmann

  • Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

    Volker Brinkmann;Thomas Geiger;Sefik Alkan;Christoph H. Heusser

  • FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.

    Daniel D. Pinschewer;Adrian F. Ochsenbein;Bernhard Odermatt;Volker Brinkmann

  • Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

    Teresa Sanchez;Tatiana Estrada-Hernandez;Ji-Hye Paik;Miing-Tao Wu

  • T cells become licensed in the lung to enter the central nervous system

    Francesca Odoardi;Christopher Sie;Kristina Streyl;Vijay K. Ulaganathan

  • FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

    Volker Brinkmann;Kevin R Lynch

  • The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.

    P Gergely;B Nuesslein-Hildesheim;Danilo Guerini;Volker Brinkmann

  • Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

    Bongnam Jung;Hideru Obinata;Sylvain Galvani;Karen Mendelson

  • Fingolimod provides long‐term protection in rodent models of cerebral ischemia

    Ying Wei;Muge Yemisci;Hyung-Hwan Kim;Lai Ming Yung

  • FTY720: altered lymphocyte traffic results in allograft protection.

    Volker Brinkmann;Daniel D. Pinschewer;Lili Feng;Shizhong Chen

  • Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

    John Camm;Timothy Hla;Rajesh Bakshi;Volker Brinkmann

  • FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation.

    Volker Brinkmann;Daniel Pinschewer;Kenji Chiba;Lilli Feng

  • Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets.

    V Brinkmann;C Kristofic

  • Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

    M. Mehling;R. Lindberg;F. Raulf;J. Kuhle

Frequent Co-Authors

Christoph Heusser
Christoph Heusser Novartis (Switzerland)
Daniel D. Pinschewer
Daniel D. Pinschewer University of Basel
Reinhold Förster
Reinhold Förster Hannover Medical School
Timothy Hla
Timothy Hla Harvard University
Richard L. Proia
Richard L. Proia National Institutes of Health
Jason G. Cyster
Jason G. Cyster University of California, San Francisco
Andreas Billich
Andreas Billich Novartis (Switzerland)
Guy Delespesse
Guy Delespesse University of Montreal
Christoph Hess
Christoph Hess University of Cambridge
Jonathan S. Serody
Jonathan S. Serody University of North Carolina at Chapel Hill

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