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Immunology

D-Index
48
Citations
12809
World Ranking
4394
National Ranking
96

Overview

Christoph Heusser is affiliated with Novartis (Switzerland) and conducts research primarily in the field of medicine. Their work covers several subfields including physiology, immunology and allergy, radiology, nuclear medicine and imaging, as well as immunology.

The scientist's recent research outputs include studies published in reputable venues such as Nature Communications and Clinical & Translational Immunology. Notable papers encompass:

  • The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab, 2020, Nature Communications
  • Ligelizumab treatment for severe asthma: learnings from the clinical development programme, 2021, Clinical & Translational Immunology

Their research frequently addresses topics related to asthma and respiratory diseases, monoclonal and polyclonal antibodies, mast cells and histamine, allergic rhinitis and sensitization, as well as food allergy and anaphylaxis.

  • Asthma and respiratory diseases
  • Monoclonal and Polyclonal Antibodies Research
  • Mast cells and histamine
  • Allergic Rhinitis and Sensitization
  • Food Allergy and Anaphylaxis Research

The scientist collaborates regularly with several coauthors, including P. Gasser, Svetlana S. Tarchevskaya, Pascal Guntern, Daniel Brigger, and Rahel Ruppli.

  • P. Gasser
  • Svetlana S. Tarchevskaya
  • Pascal Guntern
  • Daniel Brigger
  • Rahel Ruppli

Publication venues where their work appears consist of Nature Communications and Clinical & Translational Immunology, reflecting their research focus on immunology and translational medical studies.

Best Publications

  • Detection of intracellular cytokines by flow cytometry

    Thomas Jung;Uwe Schauer;Christoph Heusser;Christine Neumann

  • Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

    P Bradding;J A Roberts;K M Britten;S Montefort

  • Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

    P. Bradding;I.H. Feather;S.J. Wilson;P.G. Bardin

  • Interleukin 4 is localized to and released by human mast cells

    P Bradding;I H Feather;P H Howarth;R Mueller

  • Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

    Volker Brinkmann;Thomas Geiger;Sefik Alkan;Christoph H. Heusser

  • Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

    Unknown

  • Human peripheral blood basophils primed by interleukin 3(IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation

    Thomas Brunner;Christoph Heusser;Clemens Dahinden

  • Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

    A J Coyle;G Le Gros;C Bertrand;S Tsuyuki

  • Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody.

    A J Coyle;K Wagner;C Bertrand;S Tsuyuki

  • Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

    A Bandeira;T Mota-Santos;S Itohara;S Degermann

  • Effect of Chemical and Enzymatic Radioiodination on in Vitro Human Clq Activities

    Christoph Heusser;Mary Boesman;John H. Nordin;Henri Isliker

  • The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.

    J. Corne;R. Djukanovic;L. Thomas;J.O. Warner

  • RECEPTORS FOR IgG: SUBCLASS SPECIFICITY OF RECEPTORS ON DIFFERENT MOUSE CELL TYPES AND THE DEFINITION OF TWO DISTINCT RECEPTORS ON A MACROPHAGE CELL LINE*

    Christoph H. Heusser;Clark L. Anderson;Howard M. Grey

  • Autonomous activation of B and T cells in antigen-free mice.

    Pablo Pereira;Luciana Forni;Eva-Lotta Larsson;Max Cooper

  • Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes.

    CY Wu;M Sarfati;C Heusser;S Fournier

  • Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes

    Ulf Andersson;Jan Andersson;Anders Lindfors;Kathrin Wagner

  • Immunobiology of Murine T Cruzi Infection: The Predominance of Parasite-nonspecific Responses and the Activation of TCRIT Cells

    Paola Minoprio;Shigeyoshi Itohara;Christoph Heusser;Susumu Tonegawa

  • The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab.

    Pascal Gasser;Svetlana S. Tarchevskaya;Pascal Guntern;Daniel Brigger

  • Anti-interleukin 5 But Not Anti-IgE Prevents Airway Inflammation and Airway Hyperresponsiveness

    Eckard Hamelmann;Greg Cieslewicz;Jurgen Schwarze;T. Ishizuka

  • Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG1 and IgE.

    Susanne Bergstedt-Lindqvist;Hee-Bom Moon;Ulla Persson;Göran Möller

  • Bee venom phospholipase A2-specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration.

    José M. Carballido;Nicole Carballido-Perrig;GeróNimo Terres;Christoph H. Heusser

  • Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens.

    M Troye-Blomberg;E M Riley;L Kabilan;M Holmberg

  • Different Adaptations of IgG Effector Function in Human and Nonhuman Primates and Implications for Therapeutic Antibody Treatment

    Max Warncke;Thomas Calzascia;Michele Coulot;Nicole Balke

  • Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.

    S Folli;G Wagnières;A Pèlegrin;J M Calmes

Frequent Co-Authors

Volker Brinkmann
Volker Brinkmann Novartis (Switzerland)
Kurt Blaser
Kurt Blaser University of Zurich
Clemens A. Dahinden
Clemens A. Dahinden University of Bern
André Pèlegrin
André Pèlegrin University of Montpellier
Antonio Coutinho
Antonio Coutinho Instituto Gulbenkian de Ciência
Thomas Brunner
Thomas Brunner University of Konstanz
Antoine Blancher
Antoine Blancher Paul Sabatier University
Walter Sebald
Walter Sebald University of Würzburg
Volker Brinkmann
Volker Brinkmann Max Planck Society
Roberto Manetti
Roberto Manetti University of Sassari

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