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Immunology

D-Index
75
Citations
26469
World Ranking
1961
National Ranking
961

Research.com Recognitions

  • 2021 - Distinguished Fellows of the American Association of Immunologists (AAI)

Overview

Ann Marshak-Rothstein is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans primarily the fields of immunology and microbiology, with 64 publications in this area, alongside 24 contributions to medical science. Their work covers several subfields, including immunology, molecular biology, infectious diseases, ophthalmology, and oncology.

Their main research topics focus on immune system mechanisms and disorders. These include interferon and immune responses, T-cell and B-cell immunology, immune cell function and interaction, inflammasome and immune disorders, immune response and inflammation, viral infections and vectors, as well as atherosclerosis and cardiovascular diseases.

Marshak-Rothstein has published extensively with frequent collaborators, including Katherine A. Fitzgerald, Kevin MingJie Gao, Kerstin Nündel, Kristy Chiang, and Jillian M. Richmond. Their work appears in several scientific outlets, with the most frequent publication venues being bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Journal of Investigative Dermatology, Immunity, and Frontiers in Immunology.

Selected recent papers authored by Marshak-Rothstein or involving their research include:

  • Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells (2021, Immunity)
  • cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE (2021, Frontiers in Immunology)
  • Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFNγ-dependent mortality in STING gain-of-function mice (2022, Proceedings of the National Academy of Sciences)
  • Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2 (2021, JCI Insight)
  • Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration (2024, Cell Reports)

Marshak-Rothstein was recognized as a Distinguished Fellow of the American Association of Immunologists (AAI) in 2021.

Best Publications

  • Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

    Elizabeth A. Leadbetter;Ian R. Rifkin;Andreas M. Hohlbaum;Britte C. Beaudette

  • Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

    Shyr-Te Ju;D. J. Panka;Haili Cui;R. Ettinger

  • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

    Jane Tian;Ana Maria Avalos;Su-Yau Mao;Bo Chen

  • Toll-like receptors in systemic autoimmune disease

    Ann Marshak-Rothstein

  • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

    Christina M. Lau;Courtney Broughton;Abigail S. Tabor;Shizuo Akira

  • The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

    Bernardo S Franklin;Lukas Bossaller;Dominic De Nardo;Jacqueline M Ratter

  • The role of clonal selection and somatic mutation in autoimmunity.

    Mark J. Shlomchik;Ann Marshak-Rothstein;Claudia B. Wolfowicz;Thomas L. Rothstein

  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

    M Shlomchik;M Mascelli;H Shan;M Z Radic

  • Properties and Applications of Monoclonal Antibodies Directed against Determinants of the Thy-1 Locus

    Ann Marshak-Rothstein;Pamela Fink;Thomas Gridley;David H. Raulet

  • Activation of autoreactive B cells by CpG dsDNA

    Gregory A Viglianti;Christina M Lau;Timothy M Hanley;Benjamin A Miko

  • Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

    Melissa W. Boulé;Courtney Broughton;Fabienne Mackay;Shizuo Akira

  • Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

    Ian R. Rifkin;Elizabeth A. Leadbetter;Liliana Busconi;Gregory Viglianti

  • Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

    Ann Marshak-Rothstein;Ian R. Rifkin

  • Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.

    Thomas L. Rothstein;Julia K. M. Wang;David J. Panka;Linda C. Foote

  • Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM

    Marianne Boes;Tara Schmidt;Kathrin Linkemann;Britte C. Beaudette

  • Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells

    Shyr-Te Ju;Haili Cui;David J. Panka;Rachel Ettinger

  • Response to self antigen imprints regulatory memory in tissues

    Michael D. Rosenblum;Iris K. Gratz;Jonathan S. Paw;Karen Lee

  • Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

    Lukas Bossaller;Ping-I Chiang;Christian Schmidt-Lauber;Sandhya Ganesan

  • Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival.

    Andreas M. Hohlbaum;Signa Moe;Ann Marshak-Rothstein

  • Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice.

    E J Israel;V K Patel;S F Taylor;A Marshak-Rothstein

Frequent Co-Authors

Eicke Latz
Eicke Latz German Rheumatism Research Centre
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Thomas L. Rothstein
Thomas L. Rothstein Western Michigan University
Mark J. Shlomchik
Mark J. Shlomchik University of Pittsburgh
Michael P. Cancro
Michael P. Cancro University of Pennsylvania
Ellen M. Gravallese
Ellen M. Gravallese Brigham and Women's Hospital
Shizuo Akira
Shizuo Akira Osaka University
Abul K. Abbas
Abul K. Abbas University of California, San Francisco
Sheng Xiao
Sheng Xiao Brigham and Women's Hospital

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