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Biology and Biochemistry

D-Index
57
Citations
17383
World Ranking
13586
National Ranking
5763

Overview

Richard M. Higashi is affiliated with the University of Kentucky in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, immunology, cancer research, oncology, and clinical biochemistry, with a total of 61 publications categorized under biochemistry, genetics, and molecular biology.

Their research topics encompass various aspects of cancer, hypoxia, and metabolism, as well as immune cells in cancer and metabolomics and mass spectrometry studies. Additional main topics include immune cell function and interaction, epigenetics and DNA methylation, metabolism and genetic disorders, and RNA modifications related to cancer.

The scientist has coauthored frequently with several researchers, including Andrew N. Lane, Teresa W.-M. Fan, Teresa Cassel, Penghui Lin, and Saeed Daneshmandi. These collaborations reflect ongoing research efforts in overlapping and complementary areas of interest.

Richard M. Higashi has published multiple papers in notable scientific journals. Some of the recent publications include:

  • Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase, 2020, Nature Communications
  • Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response, 2023, Nature Metabolism
  • Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function, 2021, Cell Reports
  • 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function, 2021, eLife
  • Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies, 2024, Nature Communications

The most frequent publication venues for Higashi include Cancer Research, Metabolites, Journal of Biological Chemistry, Free Radical Biology and Medicine, and Nature Communications. Cancer Research hosts the largest number of their publications, followed by Metabolites and Journal of Biological Chemistry.

Best Publications

  • Proposed minimum reporting standards for chemical analysis

    Lloyd W. Sumner;Alexander Amberg;Dave Barrett;Michael H. Beale

  • Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

    Anne Le;Andrew N. Lane;Max Hamaker;Sminu Bose

  • Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

    Manish Sud;Eoin Fahy;Dawn Cotter;Kenan Azam

  • The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

    Mariia O. Yuneva;Teresa W.M. Fan;Thaddeus D. Allen;Richard M. Higashi

  • Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

    Teresa Wm Fan;Andrew N. Lane;Richard M. Higashi;Mohamed A Elahadi Farag

  • Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells

    Han Xie;Jun-ichi Hanai;Jian-Guo Ren;Lev Kats

  • Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

    Katherine Sellers;Matthew P. Fox;Michael Bousamra;Stephen P. Slone

  • Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

    Erika M. Palmieri;Marieli Gonzalez-Cotto;Walter A. Baseler;Luke C. Davies

  • Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California.

    Teresa W.-M Fan;Swee J Teh;David E Hinton;Richard M Higashi

  • An obligatory role for neurotensin in high-fat-diet-induced obesity

    Jing Li;Jun S. Song;Yekaterina Y. Zaytseva;Yajuan Liu

  • Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS

    Teresa W.-M. Fan;Andrew N. Lane;Moshe Shenker;John P. Bartley

  • Stable isotope-resolved metabolomics and applications for drug development

    Teresa W.-M. Fan;Pawel K. Lorkiewicz;Katherine Sellers;Hunter N.B. Moseley

  • COMPREHENSIVE ANALYSIS OF ORGANIC LIGANDS IN WHOLE ROOT EXUDATES USING NUCLEAR MAGNETIC RESONANCE AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY

    Teresa W.-M. Fan;Andrew N. Lane;Judy Pedler;David Crowley

  • Combined use of 1H-NMR and GC-MS for metabolite monitoring and in vivo 1H-NMR assignments

    Teresa W.-M. Fan;Richard M. Higashi;Andrew N. Lane;Oleg Jardetzky

  • Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2016: bioinformatics

    Eric C. Rouchka;Julia H. Chariker;David A. Tieri;Juw Won Park

  • Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis

    Jason E. Podrabsky;James P. Lopez;Teresa W. M. Fan;Richard Higashi

  • Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

    Min Liu;Min Liu;Fengling Luo;Fengling Luo;Chuanlin Ding;Sabrin Albeituni

  • Interactive effects of Ca2+ and NaCl salinity on the ionic relations and proline accumulation in the primary root tip of Sorghum bicolor

    Timothy D. Colmer;Teresa W.-M. Fan;Richard M. Higashi;Andre Lauchli

  • Erratum to: A novel deconvolution method for modeling UDP-N

    Hunter Nb Moseley;Andrew N Lane;Alex C Belshoff;Richard M Higashi

  • Isotopomer-based metabolomic analysis by NMR and mass spectrometry.

    Andrew N. Lane;Teresa W.‐M. Fan;Richard M. Higashi

Frequent Co-Authors

Teresa W.-M. Fan
Teresa W.-M. Fan University of Kentucky
Andrew N. Lane
Andrew N. Lane University of Kentucky
Jun Yan
Jun Yan University of Louisville
Pankaj Seth
Pankaj Seth National Brain Research Centre
Gary N. Cherr
Gary N. Cherr University of California, Davis
David E. Crowley
David E. Crowley University of California, Riverside
Clary B. Clish
Clary B. Clish Broad Institute
Ramesh C. Gupta
Ramesh C. Gupta University of Louisville
Heidi L. Weiss
Heidi L. Weiss University of Kentucky
Swee J. Teh
Swee J. Teh University of California, Davis

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