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Yasushi Yamazoe

Yasushi Yamazoe

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
15361
World Ranking
6762
National Ranking
450

Overview

Yasushi Yamazoe is affiliated with Tohoku University in Japan and has contributed to research primarily in the fields of pharmacology, toxicology, and pharmaceutics, with a substantial focus also on biochemistry, genetics, and molecular biology. Their publication record includes significant work in pharmacology, computational theory and mathematics, molecular biology, spectroscopy, and biochemistry.

The scientist's research largely centers on pharmacogenetics and drug metabolism, with additional attention to computational drug discovery methods, analytical chemistry and chromatography, eicosanoids and hypertension pharmacology, chemical reactions and isotopes, cancer treatment and pharmacology, as well as pesticide and herbicide environmental studies.

Yamazoe has published across multiple venues, notably contributing eleven papers to Drug Metabolism and Pharmacokinetics and seven to Food Safety. Other venues include Molecular Pharmacology, Genes and Environment, and Toxicology Letters.

Recent papers include the following:

  • Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system (2020, Food Safety)
  • Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches (2022, Food Safety)
  • Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study (2020, Drug Metabolism and Pharmacokinetics)
  • Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template (2020, Drug Metabolism and Pharmacokinetics)

The scientist frequently collaborates with co-authors including Kouichi Yoshinari, Norie Murayama, Takashi Yamada, Masahiro Tohkin, and Yoshiya Yamamura.

The main topics of Yamazoe's research can be summarized as follows:

  • Pharmacogenetics and Drug Metabolism
  • Computational Drug Discovery Methods
  • Analytical Chemistry and Chromatography
  • Eicosanoids and Hypertension Pharmacology
  • Chemical Reactions and Isotopes
  • Cancer Treatment and Pharmacology
  • Pesticide and Herbicide Environmental Studies

They have worked extensively on the CYP3A family of enzymes, focusing on the development and application of template systems to study ligand interactions and metabolic mechanisms. Their studies include both experimental and computational approaches to understand drug metabolism pathways.

Yamazoe's contributions span a combination of theoretical and applied research, touching areas from molecular pharmacology to environmental and chemical safety studies. This interdisciplinary approach is reflected in the diversity of journals and topics covered in their publication history.

Best Publications

  • Nomenclature for N-acetyltransferases.

    K P Vatsis;W W Weber;D A Bell;J M Dupret

  • Role of Furanocoumarin Derivatives on Grapefruit Juice-Mediated Inhibition of Human CYP3A Activity

    Lian-Qing Guo;Katsuyuki Fukuda;Tomihisa Ohta;Yasushi Yamazoe

  • Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats.

    Tetsuya Kamataki;Kaori Maeda;Yasushi Yamazoe;Tsuneji Nagai

  • Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450

    Wichittra Tassaneeyakul;Lian-Qing Guo;Katsuyuki Fukuda;Tomihisa Ohta

  • Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

    Katsuyuki Fukuda;Tomihisa Ohta;Yoshiteru Oshima;Noriko Ohashi

  • Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.

    Y Yamazoe;M Shimada;N Murayama;R Kato

  • Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates.

    Ryuichi Kato;Yasushi Yamazoe

  • Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity.

    R. Kato;Y. Yamazoe

  • Structural similarity and diversity of sulfotransferases

    Yasushi Yamazoe;Kiyoshi Nagata;Shogo Ozawa;Ryuichi Kato

  • Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA

    Yoshiteru Kamiyama;Yoshiteru Kamiyama;Tsutomu Matsubara;Kouichi Yoshinari;Kiyoshi Nagata;Kiyoshi Nagata

  • Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.

    Hirotaka Kitada;Masaaki Miyata;Toshifumi Nakamura;Aki Tozawa

  • Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ.

    Masaaki Miyata;Masayuki Furukawa;Koichi Takahashi;Frank J. Gonzalez

  • Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene.

    Kiyoshi Nagata;Shogo Ozawa;Masaaki Miyata;Miki Shimada

  • Cytochrome P450 in livers of diabetic rats: Regulation by growth hormone and insulin

    Yasushi Yamazoe;Norie Murayama;Miki Shimada;Kiyomi Yamauchi

  • Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.

    Shigeki Matsumoto;Tomoe Hirama;Tsutomu Matsubara;Kiyoshi Nagata

  • Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate.

    Yasushi Yamazoe;Miki Shimada;Tetsuya Kamataki;Ryuichi Kato

  • Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.

    Toshio Yasumori;Kiyoshi Nagata;Shen K. Yang;Lai-shun Chen

  • Isolation and Characterization of a New Major Intestinal CYP3A Form, CYP3A62, in the Rat

    Tsutomu Matsubara;Hye Ji Kim;Masaaki Miyata;Miki Shimada

  • Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase

    Kenichiro Ogura;Jiro Kajita;Hiroyuki Narihata;Tadashi Watabe

  • Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines.

    Shogo Ozawa;Yong Ming Tang;Yasushi Yamazoe;Ryuichi Kato

Frequent Co-Authors

Ryuichi Kato
Ryuichi Kato Keio University
Tetsuya Kamataki
Tetsuya Kamataki Hokkaido University
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Kazuki Saito
Kazuki Saito Chiba University
Peter I. Mackenzie
Peter I. Mackenzie Flinders University
Makoto Hayashi
Makoto Hayashi makoto international consulting
Shogo Ozawa
Shogo Ozawa Iwate Medical University
Tsuneji Nagai
Tsuneji Nagai Nagai Foundation
Takeji Nishikawa
Takeji Nishikawa Keio University
Tomihisa Ohta
Tomihisa Ohta Kanazawa University

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