World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
67
Citations
14720
World Ranking
1580
National Ranking
132

Overview

Makoto Hayashi is affiliated with makoto international consulting in Japan and has contributed extensively in the fields of biochemistry, genetics and molecular biology, environmental science, and medicine. Their research spans multiple subfields including cancer research, health, toxicology and mutagenesis, chemical health and safety, epidemiology, and small animals.

The primary focus of their work involves carcinogens and genotoxicity assessment, effects and risks of endocrine disrupting chemicals, chemical safety and risk management, animal testing and alternatives, DNA repair mechanisms, genetically modified organisms research, and computational drug discovery methods.

Hayashi's notable recent publications include:

  • "Opinion: regulatory genotoxicity: past, present and future," 2022, Genes and Environment
  • ""Statistical significance" and other important considerations in genotoxicity safety testing," 2023, Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Other significant related works where Hayashi is a co-author or closely associated include:

  • "Micronucleus test using formalin-fixed rat glandular stomach and colon," 2023, Genes and Environment
  • "Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 2-week or 4-week repeated dose studies," 2022, Genes and Environment
  • "Target-specific micronucleus induction by colon carcinogens: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 1,2-dimethylhydrazine," 2020, Regulatory Toxicology and Pharmacology

Frequent coauthors collaborating with Hayashi include Wakako Ohyama, Takashi Omori, Yohei Fujiishi, Emiko Okada, and Kazunori Narumi, reflecting collaborative efforts mainly in genotoxicity and toxicological research topics.

Their work has been published mostly in journals such as Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Genes and Environment, Regulatory Toxicology and Pharmacology, Therapeutic Advances in Respiratory Disease, and Respiratory Medicine.

Best Publications

  • Primary mutagenicity screening of food additives currently used in Japan

    M. Ishidate;T. Sofuni;K. Yoshikawa;M. Hayashi

  • The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides.

    Makoto Hayashi;Takeshi Morita;Yukio Kodama;Toshio Sofuni

  • In vivo rodent micronucleus assay: protocol, conduct and data interpretation.

    Gopala Krishna;Makoto Hayashi

  • An application of Acridine Orange fluorescent staining to the micronucleus test.

    M. Hayashi;T. Sofuni;M. Ishidate

  • Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.

    Takeshi Morita;Norihide Asano;Takumi Awogi;Yu F Sasaki

  • Development of genotoxicity assay systems that use aquatic organisms

    M Hayashi;T Ueda;K Uyeno;K Wada

  • Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals.

    M. Hayashi;M. Kishi;T. Sofuni;M. Ishidate

  • Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU).

    Taijiro Matsushima;Makoto Hayashi;Atsuko Matsuoka;Motoi Ishidate

  • Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test.

    A. Matsuoka;N. Yamazaki;T. Suzuki;M. Hayashi

  • Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS. MMS

    Akihiro Wakata;Youichi Miyamae;Sei-ichi Sato;Takayoshi Suzuki

  • Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test

    Masamitsu Honma;Makoto Hayashi;Hiroyasu Shimada;Noriho Tanaka

  • In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

    Makoto Hayashi;James T MacGregor;David G Gatehouse;David H Blakey

  • Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS).

    Shuichi Hamada;Sizuyo Sutou;Takeshi Morita;Akihiro Wakata

  • Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow

    Makoto Hayashi;Toshio Sofuni;Motoi Ishidate

  • Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays.

    M. Matsui;K. Matsui;Y. Kawasaki;Y. Oda

  • Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells

    Masamitsu Honma;Makoto Hayashi;Toshio Sofuni

  • Genotoxicity of microcystin-LR in human lymphoblastoid TK6 cells.

    Li Zhan;Hiroko Sakamoto;Mayumi Sakuraba;De Sheng Wu

  • Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells.

    Naoki Koyama;Hiroko Sakamoto;Mayumi Sakuraba;Tomoko Koizumi

  • Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

    Hiroshi Suzuki;Naohiro Ikeda;Kazuo Kobayashi;Yukari Terashima

  • The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice.

    Takayoshi Suzuki;Makoto Hayashi;Toshio Sofuni;Brian C. Myhr

Frequent Co-Authors

Toshio Sofuni
Toshio Sofuni National Institutes of Health
James T. MacGregor
James T. MacGregor United States Food and Drug Administration
Takehiko Nohmi
Takehiko Nohmi Gifu University
Stephen D. Dertinger
Stephen D. Dertinger University of Rochester
Yasushi Yamazoe
Yasushi Yamazoe Tohoku University
Takayoshi Suzuki
Takayoshi Suzuki Osaka University
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Kazuo Kobayashi
Kazuo Kobayashi National Institute of Infectious Diseases
Minako Nagao
Minako Nagao National Cancer Research Institute, UK
Toshikazu Ushijima
Toshikazu Ushijima National Cancer Centre

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