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Stephen D. Dertinger

Stephen D. Dertinger

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
7661
World Ranking
16376
National Ranking
6771

Overview

Stephen D. Dertinger is affiliated with the University of Rochester in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology, Cancer Research, and Genetics. Additional subfields of interest include Computational Theory and Mathematics as well as Health, Toxicology and Mutagenesis.

The scientist's work encompasses a range of topics including:

  • Carcinogens and Genotoxicity Assessment
  • DNA Repair Mechanisms
  • Molecular Biology Techniques and Applications
  • Computational Drug Discovery Methods
  • Epigenetics and DNA Methylation
  • Effects and risks of endocrine disrupting chemicals
  • Hemoglobinopathies and Related Disorders

Stephen D. Dertinger has published extensively, with recent notable papers including:

  • <scp>AOP</scp> report: Development of an adverse outcome pathway for oxidative <scp>DNA</scp> damage leading to mutations and chromosomal aberrations, 2022, Environmental and Molecular Mutagenesis
  • Absence of hydroxyurea-induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia, 2021, British Journal of Haematology
  • Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose, 2022, Environmental and Molecular Mutagenesis
  • Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice, 2021, Cell Reports
  • Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds, 2020, Environmental and Molecular Mutagenesis

Frequent co-authors include:

  • Jeffrey C. Bemis
  • Svetlana L. Avlasevich
  • Dorothea K. Torous
  • Steven M. Bryce
  • Daniel J. Roberts

The main publication venues for their work predominantly include:

  • Environmental and Molecular Mutagenesis
  • Mutagenesis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • British Journal of Haematology
  • Cell Reports

Best Publications

  • In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring.

    Makoto Hayashi;James T. MacGregor;David G. Gatehouse;Ilse-Dore Adler

  • In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity.

    Steven M. Bryce;Jeffrey C. Bemis;Svetlana L. Avlasevich;Stephen D. Dertinger

  • In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

    Svetlana L. Avlasevich;Steven M. Bryce;Siân E. Cairns;Stephen D. Dertinger

  • In vivo mutation assay based on the endogenous Pig-a locus.

    Steven M. Bryce;Jeffrey C. Bemis;Stephen D. Dertinger

  • The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment

    Vasily N. Dobrovolsky;Daishiro Miura;Robert H. Heflich;Stephen D. Dertinger

  • In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

    Makoto Hayashi;James T MacGregor;David G Gatehouse;David H Blakey

  • Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer.

    Stephen D. Dertinger;Dorothea K. Torous;Kenneth R. Tometsko

  • The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

    B. Bhaskar Gollapudi;Anthony M. Lynch;Robert H. Heflich;Stephen D. Dertinger

  • When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.

    Stephen D. Dertinger;Steven M. Bryce;Souk Phonethepswath;Svetlana L. Avlasevich

  • Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.

    Ellen C. Henry;Andrew S. Kende;George Rucci;Michael J. Totleben

  • Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial

    Zora R. Rogers;Winfred C. Wang;Zhaoyu Luo;Rathi V. Iyer

  • Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies

    Stephen D. Dertinger;Souk Phonethepswath;Dean Franklin;Pamela Weller

  • Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds

    Stephen D. Dertinger;Souk Phonethepswath;Svetlana L. Avlasevich;Dorothea K. Torous

  • Erythrocyte-based Pig-a gene mutation assay: Demonstration of cross-species potential

    Souk Phonethepswath;Steven M. Bryce;Jeffrey C. Bemis;Stephen D. Dertinger

  • Pig-a Mutation: Kinetics in Rat Erythrocytes Following Exposure to Five Prototypical Mutagens

    Souk Phonethepswath;Dean Franklin;Dorothea K. Torous;Steven M. Bryce

  • Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

    Dorothea K. Torous;Nikki E. Hall;Francis G. Murante;Sarah E. Gleason

  • In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates

    Mary B. Zelinski;Mark K. Murphy;Maralee S. Lawson;Andrea Jurisicova

  • Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model

    Andrew M. Tometsko;Dorothea K. Torous;Stephen D. Dertinger

  • Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.

    Stephen D. Dertinger;Daniel A. Nazarenko;Allen E. Silverstone;Thomas A. Gasiewicz

  • Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.

    Stephen D. Dertinger;Kevin Camphausen;James T. MacGregor;Michelle E. Bishop

Frequent Co-Authors

James T. MacGregor
James T. MacGregor United States Food and Drug Administration
Thomas A. Gasiewicz
Thomas A. Gasiewicz University of Rochester Medical Center
Robert H. Heflich
Robert H. Heflich United States Food and Drug Administration
James Palis
James Palis University of Rochester Medical Center
Makoto Hayashi
Makoto Hayashi makoto international consulting
David Kirkland
David Kirkland Covance (United States)
Russell E. Ware
Russell E. Ware Cincinnati Children's Hospital Medical Center
Gunnar Brunborg
Gunnar Brunborg Norwegian Institute of Public Health
Carole L. Yauk
Carole L. Yauk University of Ottawa
John W. Wills
John W. Wills Pennsylvania State University

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