David Kirkland

Overview

Best Publications

• Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity

  David Kirkland;Marilyn Aardema;Leigh Henderson;Lutz Müller

  1044
  Citations

• How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

  David Kirkland;Stefan Pfuhler;David Tweats;Marilyn Aardema

  479
  Citations

• Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: III. Appropriate follow-up testing in vivo

  David Kirkland;Günter Speit

  470
  Citations

• A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.

  David Kirkland;Lesley Reeve;David Gatehouse;Philippe Vanparys

  286
  Citations

• Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type.

  Paul Fowler;Katie Smith;Jamie Young;Laura Jeffrey

  277
  Citations

• Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop.

  David Kirkland;Peter Kasper;Lutz Müller;Raffaella Corvi

  238
  Citations

• Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells.

  Eric K. Dufour;Tirukalikundram Kumaravel;Gerhard J. Nohynek;David Kirkland

  230
  Citations

• Report from working group on in vitro tests for chromosomal aberrations.

  Sheila M. Galloway;Marilyn J. Aardema;Motoi Ishidate;James L. Ivett

  222
  Citations

• Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.

  David Kirkland;Peter Kasper;Hans Jörg Martus;Lutz Müller

  202
  Citations

• Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles.

  David Kirkland;Marilyn Aardema;Lutz Müller;Hayashi Makoto

  191
  Citations

• Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds.

  David J Kirkland;Lutz Müller

  182
  Citations

• Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product

  G. Eichenbaum;M. Johnson;D. Kirkland;P. O’Neill

  174
  Citations

• Review of genotoxicity studies of glyphosate and glyphosate-based formulations

  Larry D. Kier;David J. Kirkland

  166
  Citations

• Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test: I. Theoretical aspects

  E. Lorge;M. Hayashi;S. Albertini;D. Kirkland

  166
  Citations

• Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing

  V. Thybaud;M. Aardema;J. Clements;K. Dearfield

  165
  Citations

• An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]

  Gerhard J. Nohynek;David Kirkland;Daniel Marzin;Herve Toutain

  147
  Citations

• In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results

  D. J. Kirkland;M. Aardema;N. Banduhn;P. Carmichael

  142
  Citations

• A review of the carcinogenic potential of glyphosate by four independent expert panels and comparison to the IARC assessment

  Gary M. Williams;Marilyn Aardema;John Acquavella;Sir Colin Berry

  129
  Citations

• Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes.

  D.J. Kirkland;L. Henderson;D. Marzin;L. Müller

  126
  Citations

• Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement

  Paul Fowler;Paul Fowler;Robert Smith;Katie Smith;Jamie Young

  105
  Citations