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Biology and Biochemistry

D-Index
60
Citations
11117
World Ranking
12100
National Ranking
5182

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles N. Falany is a researcher affiliated with the University of Alabama at Birmingham in the United States. Their work spans various aspects of biochemistry, genetics, and molecular biology, with notable contributions in medicine.

The main fields of study covered by their research include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad areas, subfields of particular focus involve:

  • Molecular Biology
  • Spectroscopy
  • Pharmacology
  • Epidemiology
  • Physiology

The research topics addressed cover multiple important biomedical themes, such as:

  • Mass Spectrometry Techniques and Applications
  • Autophagy in Disease and Therapy
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Pancreatic function and diabetes
  • Ion channel regulation and function
  • Cancer therapeutics and mechanisms

Their recent publications illustrate this diversity, including:

  • "Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective" (2020), published in Autophagy
  • "Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress" (2022), published in Scientific Reports
  • "N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells" (2023), published in Scientific Reports
  • "Sulfotransferase 4A1 Coding Sequence and Protein Structure Are Highly Conserved in Vertebrates" (2024), published in Genes
  • "Human cytosolic steroid sulfotransferases: Versatile and rapid activity assays" (2023), published in Methods in enzymology on CD-ROM/Methods in enzymology

Frequent publication venues include Scientific Reports, Autophagy, Genes, and Methods in Enzymology, reflecting the interdisciplinary nature of the research.

Their research collaborations often involve:

  • Robert C.A.M. van Waardenburg
  • Mohammed Iqbal Hossain
  • Jun Hee Lee
  • Patrick L. Garcia
  • Shaida A. Andrabi

Charles N. Falany has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2006.

Best Publications

  • Enzymology of human cytosolic sulfotransferases.

    Charles N. Falany

  • Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs

    Monique Kester;S. Bulduk;Dick Tibboel;W. Meinl

  • Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase.

    Charles N. Falany;Victor Krasnykh;Josie L. Falany

  • Sulfuryl Transfer: The Catalytic Mechanism of Human Estrogen Sulfotransferase

    Huiping Zhang;Olga Varmalova;Froyland M. Vargas;Charles N. Falany

  • Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.

    C.N. Falany;M.R. Johnson;S. Barnes;R.B. Diasio

  • Steroid sulfation by expressed human cytosolic sulfotransferases.

    Charles N. Falany;James Wheeler;Tae Sung Oh;Josie L. Falany

  • Expression of Cytosolic Sulfotransferases in Normal Mammary Epithelial Cells and Breast Cancer Cell Lines

    Josie L. Falany;Charles N. Falany

  • Purification and characterization of human liver dehydroepiandrosterone sulphotransferase

    C N Falany;M E Vazquez;J M Kalb

  • Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes

    Charles N. Falany;Thomas R. Tephly

  • Molecular enzymology of human liver cytosolic sulfotransferases.

    Charles N. Falany

  • Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.

    Monique H. A. Kester;Sema Bulduk;Hans van Toor;Dick Tibboel

  • Pharmacogenetics of human cytosolic sulfotransferases.

    S Nowell;C N Falany

  • Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase

    T W Wilborn;K A Comer;T P Dooley;I M Reardon

  • Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain.

    Charles N. Falany;Xiaowei Xie;Jin Wang;Jorge Ferrer

  • Sulfotransferases: genetics and role in toxicology.

    Hansruedi Glatt;Christina E.H Engelke;Ulrike Pabel;Wera Teubner

  • Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver.

    Jin Wang;Josie L. Falany;Charles N. Falany

  • Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.

    K A Comer;J L Falany;C N Falany

  • Human Dehydroepiandrosterone Sulfotransferase

    Charles N. Falany;Kathleen A. Comer;Thomas P. Dooley;Hansruedi Glatt

  • Expression and characterization of the human 3β-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b)

    Connie A. Meloche;Charles N. Falany

  • Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator-Activated Receptor α Transcription Factor

    Hai Lin Fang;Stephen C. Strom;Hongbo Cai;Charles N. Falany

Frequent Co-Authors

Stephen Barnes
Stephen Barnes University of Alabama at Birmingham
Hansruedi Glatt
Hansruedi Glatt Federal Institute for Risk Assessment
Michael W.H. Coughtrie
Michael W.H. Coughtrie University of British Columbia
Theo J. Visser
Theo J. Visser Erasmus University Rotterdam
William E. Grizzle
William E. Grizzle University of Alabama at Birmingham
Stephen C. Strom
Stephen C. Strom Karolinska Institute
Marion Kirk
Marion Kirk University of Alabama at Birmingham
Victor Krasnykh
Victor Krasnykh The University of Texas MD Anderson Cancer Center
Robert Landsiedel
Robert Landsiedel BASF (United States)
Ralf Morgenstern
Ralf Morgenstern Karolinska Institute

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