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Neuroscience

D-Index
50
Citations
7271
World Ranking
5827
National Ranking
164

Overview

Tim Karl is a researcher affiliated with Western Sydney University in Australia. Their research primarily spans neuroscience and medicine, with a notable focus on subfields such as cellular and molecular neuroscience, molecular biology, pharmacology, neurology, and physiology.

The scope of their scientific work includes several main topics: cannabis and cannabinoid research, Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, neuroinflammation and neurodegeneration mechanisms, neurotransmitter receptor influence on behavior, tryptophan and brain disorders, as well as GABA and rice research.

Tim Karl has contributed to multiple publications in various research venues. Frequent publication outlets include Behavioural Brain Research, Frontiers in Neuroscience, Pharmacology Biochemistry and Behavior, IBRO Neuroscience Reports, and Schizophrenia Bulletin.

Their recent papers demonstrate a focus on neurodegenerative diseases and cannabinoid-based therapies. Selected works include the following:

  • Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ40 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice, 2020, Journal of Alzheimer s Disease
  • Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APPSwe/PS1ΔE9 Transgenic Female Mice, 2020, Frontiers in Pharmacology
  • Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin, 2021, Frontiers in Neuroscience
  • Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease, 2022, Frontiers in Neuroscience
  • Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease, 2022, Acta Neuropathologica

Throughout their career, Tim Karl has collaborated frequently with several co-authors, including Rose Chesworth, Georgia Watt, Rossana Rosa Porto, Erika Gyengési, and Lars M. Ittner. These partnerships reflect ongoing engagement with diverse experts in related fields.

Best Publications

  • Behavioral phenotyping of mice in pharmacological and toxicological research.

    Tim Karl;Reinhard Pabst;Stephan von Hörsten

  • In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

    Georgia Watt;Tim Karl

  • A behavioural comparison of acute and chronic Δ9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice

    Leonora E. Long;Rose Chesworth;Rose Chesworth;Xu-Feng Huang;Iain S. McGregor

  • Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease.

    Woojin S Kim;Hongyun Li;Hongyun Li;Kalani Ruberu;Kalani Ruberu;Sharon Chan;Sharon Chan

  • Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats

    Charlotte Klein;Emily Karanges;Adena Spiro;Alexander Wong

  • Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity.

    Dana Boey;Shu Lin;Tim Karl;Paul A Baldock

  • Long-term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Alzheimer's Disease Transgenic Mice

    David Cheng;Adena S Spiro;Andrew M Jenner;Brett Garner

  • Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Δ9-tetrahydrocannabinol

    Aurelie A Boucher;Aurelie A Boucher;Jonathon C Arnold;Liesl Duffy;Peter R Schofield;Peter R Schofield

  • Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia

    Tim Karl;Liesl Duffy;Anna Scimone;Richard P Harvey

  • Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice.

    David Cheng;Jac Kee Low;Warren Logge;Brett Garner

  • Behavioural profile of a new mouse model for NPY deficiency.

    Tim Karl;Liesl Duffy;Herbert Herzog

  • Y1 receptors regulate aggressive behavior by modulating serotonin pathways

    Tim Karl;Shu Lin;Christoph Schwarzer;Amanda Sainsbury

  • Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice

    Leonora E. Long;Rose Chesworth;Xu-Feng Huang;Alexander Wong

  • Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety.

    Tim Karl;Thomas Henry Johnston Burne;Herbert Herzog

  • Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation.

    Maarten van den Buuse;Maarten van den Buuse;Lena Wischhof;Ruo Xi Lee;Sally Martin

  • Cognition in transmembrane domain neuregulin 1 mutant mice

    L. Duffy;E. Cappas;D. Lai;A.A. Boucher

  • Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4

    Nadine Frerker;Leona Wagner;Raik Wolf;Ulrich Heiser

  • Behavioral profiling of NPY in aggression and neuropsychiatric diseases.

    Tim Karl;Herbert Herzog

  • Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior

    Anne E Harasta;John M Power;Georg von Jonquieres;Tim Karl

  • Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence.

    Leonora E. Long;Rose Chesworth;Xu-Feng Huang;Iain S. McGregor

  • Behavioural effects of chronic haloperidol and risperidone treatment in rats

    Tim Karl;Liesl Duffy;Elizabeth O’Brien;Izuru Matsumoto

  • The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.

    Aurelie A Boucher;Glenn E Hunt;Jacques Micheau;Xufeng Huang

Frequent Co-Authors

Xu-Feng Huang
Xu-Feng Huang University of Wollongong
Peter R. Schofield
Peter R. Schofield Neuroscience Research Australia
Gilles J. Guillemin
Gilles J. Guillemin Bionyeri Pty Ltd
Carol Dobson-Stone
Carol Dobson-Stone University of Sydney
Izuru Matsumoto
Izuru Matsumoto University of Sydney
Linda H. Bergersen
Linda H. Bergersen University of Oslo
Brian Dean
Brian Dean Florey Institute of Neuroscience and Mental Health
Gary D. Housley
Gary D. Housley University of New South Wales
Christoph Schwarzer
Christoph Schwarzer Innsbruck Medical University
Olivier Piguet
Olivier Piguet University of Sydney

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