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Neuroscience

D-Index
71
Citations
17899
World Ranking
2412
National Ranking
17

Overview

Günther Sperk is affiliated with Innsbruck Medical University in Austria and specializes primarily in neuroscience. Their research has contributed extensively to the fields of cellular and molecular neuroscience, developmental neuroscience, molecular biology, neurology, and cognitive neuroscience. The work focuses on mechanisms underlying neural function and dysfunction, with particular attention to neuropharmacology and neurophysiology.

Their main research topics include:

  • Neuroscience and neuropharmacology research
  • Anesthesia and neurotoxicity research
  • Memory and neural mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Epilepsy research and treatment
  • Neuroinflammation and neurodegeneration mechanisms
  • Ion channel regulation and function

Frequent publication venues for Sperk's research include:

  • Neuroscience
  • The Journal of Comparative Neurology
  • Brain Communications
  • Epilepsia Open
  • Frontiers in Molecular Neuroscience

Some of the recent papers authored or coauthored by Sperk are:

  • "Immunohistochemical distribution of 10 GABAA receptor subunits in the forebrain of the rhesus monkey Macaca mulatta," 2020, The Journal of Comparative Neurology
  • "Increased expression of GABAA receptor subunits associated with tonic inhibition in patients with temporal lobe epilepsy," 2021, Brain Communications

Other notable coauthors on research projects include Meinrad Drexel, Xavier Ekolle Ndode-Ekane, Anssi Lipponen, Noora Puhakka, and Asla Pitkänen. Collaboration with these researchers highlights a multidisciplinary approach within areas such as epilepsy, neuroplasticity, and neuropharmacology.

The interdisciplinary nature of Sperk's work involves the investigation of GABA receptor subunits, their role in inhibitory neurotransmission, and pathological states such as epilepsy. This is reflected in both clinical and experimental studies published in multiple neuroscience-focused journals.

Best Publications

  • GABAA receptors : Immunocytochemical distribution of 13 subunits in the adult rat brain

    S Pirker;C Schwarzer;A Wieselthaler;W Sieghart

  • Subunit composition, distribution and function of GABA(A) receptor subtypes.

    Sieghart W;Sperk G

  • Kainic acid seizures in the rat

    Günther Sperk

  • Kainic acid induced seizures: Neurochemical and histopathological changes

    G. Sperk;H. Lassmann;H. Baran;S.J. Kish

  • Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.

    A. Vezzani;D. Moneta;M. Conti;C. Richichi

  • Neuropeptide Y: emerging evidence for a functional role in seizure modulation.

    Annamaria Vezzani;Günther Sperk;William F. Colmers

  • GABAA receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits

    G Sperk;C Schwarzer;K Tsunashima;K Fuchs

  • Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat.

    G. Sperk;J. Marksteiner;B. Gruber;R. Bellmann

  • Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid

    Manfred Karobath;Gunther Sperk

  • Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice

    Amanda Sainsbury;Christoph Schwarzer;Michelle Couzens;Serguei Fetissov

  • Neuropeptide Y inhibits potassium‐stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro

    Susanne Greber;Christoph Schwarzer;Günther Sperk

  • Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

    Cristina Richichi;En Ju D Lin;Daniela Stefanin;Daniele Colella

  • Multiple and Plastic Receptors Mediate Tonic GABAA Receptor Currents in the Hippocampus

    Annalisa Scimemi;Alexey Semyanov;Günther Sperk;Dimitri M. Kullmann

  • Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat.

    C. Schwarzer;G. Sperk

  • GABAA receptor subunits in the rat hippocampus II: Altered distribution in kainic acid-induced temporal lobe epilepsy

    C Schwarzer;K Tsunashima;C Wanzenböck;K Fuchs

  • Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat.

    Christoph Schwarzer;Ulrike Berresheim;Susanne Pirker;Anna Wieselthaler

  • GABA and its receptors in epilepsy.

    Giinther Sperk;Sabine Furtinger;Christoph Schwarzer;Susanne Pirker

  • Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?

    Annamaria Vezzani;Günther Sperk

  • Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy.

    C. Schwarzer;J.M. Williamson;E.W. Lothman;A. Vezzani

  • Reduced anxiety and improved stress coping ability in mice lacking NPY‐Y2 receptors

    Alexandra Tschenett;Nicolas Singewald;Mirjana Carli;Claudia Balducci

Frequent Co-Authors

Christoph Schwarzer
Christoph Schwarzer Innsbruck Medical University
Annamaria Vezzani
Annamaria Vezzani Mario Negri Institute for Pharmacological Research
Christoph Baumgartner
Christoph Baumgartner Medical University of Vienna
Nicolas Singewald
Nicolas Singewald University of Innsbruck
Tibor Harkany
Tibor Harkany Medical University of Vienna
Christian Pifl
Christian Pifl Medical University of Vienna
Martha Feucht
Martha Feucht Medical University of Vienna
Claudia Balducci
Claudia Balducci Mario Negri Institute for Pharmacological Research
Asla Pitkänen
Asla Pitkänen University of Eastern Finland
William F. Colmers
William F. Colmers University of Alberta

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