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Biology and Biochemistry

D-Index
55
Citations
8440
World Ranking
15278
National Ranking
1201

Overview

Roger Barraclough is a researcher affiliated with the University of Liverpool in the United Kingdom. Their work primarily intersects biochemistry, genetics, and molecular biology, with a particular focus on molecular biology, oncology, and cancer research.

The scientist has contributed to the investigation of key molecular mechanisms related to protein degradation and inhibition. Their research topics include peptidase inhibition and analysis, protein degradation and inhibitors, ubiquitin and proteasome pathways, S100 proteins and annexins, protease and inhibitor mechanisms, and ATP synthase and ATPases research.

Among their recent publications are:

  • Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells, 2023, Biomolecules
  • The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis, 2021, Biomolecules

Barraclough's frequent coauthors include Thamir M. Ismail, Philip S. Rudland, Rachel G. Crick, Min Du, and Uma Shivkumar. Their work has been primarily published in the journal Biomolecules.

This profile reflects a concentration on biochemical pathways and molecular factors that affect cancer cell behavior, especially regarding metastasis and cellular migration associated with S100 proteins.

Best Publications

  • Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer.

    Philip S. Rudland;Angela Platt-Higgins;Mohamed El-Tanani;Suzete de Silva Rudland

  • Prognostic Significance of the Metastasis-inducing Protein S100A4 (p9Ka) in Human Breast Cancer

    Philip S. Rudland;Angela Platt-Higgins;Christine Renshaw;Christopher R. West

  • Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1

    B. R. Davies;M. P. A. Davies;F. E. M. Gibbs;R. Barraclough

  • Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours.

    M. P. A. Davies;P. S. Rudland;L. Robertson;E. W. Parry

  • Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer.

    Michael P.A. Davies;Dong Liu Barraclough;Ceri Stewart;Kathryn A. Joyce

  • Human Homologue of Cement Gland Protein, a Novel Metastasis Inducer Associated with Breast Carcinomas

    Dong Liu;Philip S. Rudland;D. Ross Sibson;Angela Platt-Higgins

  • ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.

    Roberto Hernan;Rami Fasheh;Christopher Calabrese;Adrian J. Frank

  • THE IDENTIFICATION OF OSTEOPONTIN AS A METASTASIS-RELATED GENE PRODUCT IN A RODENT MAMMARY TUMOUR MODEL

    Oates Aj;Barraclough R;Rudland Ps

  • Induction of Metastasis by S100P in a Rat Mammary Model and Its Association with Poor Survival of Breast Cancer Patients

    Guozheng Wang;Angela Platt-Higgins;Joe Carroll;Suzete de Silva Rudland

  • Joining S100 proteins and migration: for better or for worse, in sickness and in health

    Stephane R. Gross;Connie Goh Then Sin;Roger Barraclough;Philip S. Rudland

  • Calcium-binding protein S100A4 in health and disease

    Roger Barraclough

  • The role of osteopontin in tumorigenesis and metastasis.

    Oates Aj;Barraclough R;Rudland Ps

  • Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer.

    Barry R. Davies;Marie O'Donnell;Garrett C. Durkan;Philip S. Rudland

  • S100A4 regulates cell motility and invasion in an in vitro model for breast cancer metastasis.

    S R Jenkinson;R Barraclough;C R West;P S Rudland

  • S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes.

    S Taylor;S Herrington;W Prime;P S Rudland

  • Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells

    Bryony H Lloyd;Angela Platt-Higgins;Philip S Rudland;Roger Barraclough

  • Molecular cloning and sequence of the gene for p9Ka, a cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein

    Roger Barraclough;Janet Savin;Shyam K. Dube;Philip S. Rudland

  • Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer

    Suzete de Silva Rudland;Lee Martin;Chandeene Roshanlall;John Winstanley

  • Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients

    H E Innes;D Liu;R Barraclough;M P A Davies

  • Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer

    Angela M. Platt-Higgins;Christine A. Renshaw;Christopher R. West;John H.R. Winstanley

Frequent Co-Authors

Philip S. Rudland
Philip S. Rudland University of Liverpool
David G. Fernig
David G. Fernig University of Liverpool
John A. Smith
John A. Smith University of Alabama at Birmingham
Zihe Rao
Zihe Rao Tsinghua University
Mark Bartlam
Mark Bartlam Nankai University
Mark I. Greene
Mark I. Greene University of Pennsylvania
David G. Spiller
David G. Spiller University of Manchester
Lu-Yun Lian
Lu-Yun Lian University of Liverpool
James H. Resau
James H. Resau Van Andel Institute
David E. Neal
David E. Neal University of Cambridge

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