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Medicine

D-Index
125
Citations
54283
World Ranking
3113
National Ranking
1719

Overview

Walter J. Koch is a researcher affiliated with Temple University in the United States. Their academic work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology and Cardiology and Cardiovascular Medicine as subfields.

The scientist's research covers several core topics, including:

  • Receptor Mechanisms and Signaling
  • Extracellular Vesicles in Disease
  • Mitochondrial Function and Pathology
  • Cardiac Fibrosis and Remodeling
  • Adipose Tissue and Metabolism
  • Cardiac Electrophysiology and Arrhythmias
  • Cardiac Ischemia and Reperfusion

Walter J. Koch has contributed to numerous research articles, with notable recent papers including:

  • Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice, 2020, published in Circulation
  • KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy, 2020, published in Circulation Research
  • Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function, 2021, published in Circulation Research
  • GRK5 is a Regulator of Fibroblast Activation and Cardiac Fibrosis, 2021, published in Proceedings of the National Academy of Sciences
  • Tissue-based T Cell Activation and Viral RNA Persist for up to 2 Years After SARS-CoV-2 Infection, 2024, published in Science Translational Medicine

The scientist frequently publishes in these venues:

  • Circulation Research
  • Circulation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Molecular and Cellular Cardiology

Walter J. Koch collaborates regularly with several co-authors, among the most frequent are:

  • Erhe Gao
  • Rajika Roy
  • Cindy Benedict
  • Maria Cimini
  • Vandana Mallaredy

Best Publications

  • Seven-transmembrane-spanning receptors and heart function

    Howard A. Rockman;Walter J. Koch;Robert J. Lefkowitz

  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

    Walter J. Koch;Howard A. Rockman;Philippe Samama;RaeAnn Hamilton

  • Sequence and expression of MRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel

    Steven B. Ellis;Mark E. Williams;Nancy R. Ways;Robert Brenner

  • A novel protective effect of erythropoietin in the infarcted heart

    Cyrus J. Parsa;Akio Matsumoto;Jihee Kim;Ryan U. Riel

  • Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

    Mohsin Khan;Emily Nickoloff;Tatiana Abramova;Jennifer Johnson

  • A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

    Erhe Gao;Yong Hong Lei;Xiying Shang;Z. Maggie Huang

  • Adrenergic nervous system in heart failure: pathophysiology and therapy.

    Anastasios Lymperopoulos;Giuseppe Rengo;Walter J. Koch

  • Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

    Howard A. Rockman;Kenneth R. Chien;D. O. N. G. . J. U. Choi;Guido Iaccarino

  • Structure and mechanism of the G protein-coupled receptor kinases.

    J Inglese;N J Freedman;W J Koch;R J Lefkowitz

  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.

    Wei-Zhong Zhu;Ming Zheng;Walter J. Koch;Robert J. Lefkowitz

  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.

    Shahab A. Akhter;Louis M. Luttrell;Howard A. Rockman;Guido Iaccarino

  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

    W.J. Koch;J. Inglese;W.C. Stone;R.J. Lefkowitz

  • Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress

    Ling Tao;Erhe Gao;Xiangying Jiao;Yuexing Yuan

  • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

    Walter J. Koch;Brian E. Hawes;Lee F. Allen;Robert J. Lefkowitz

  • Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

    Brian E. Hawes;Tim van Biesen;Walter J. Koch;Louis M. Luttrell

  • Biology of intracranial aneurysms: role of inflammation

    Nohra Chalouhi;Muhammad S Ali;Pascal M Jabbour;Stavropoula I Tjoumakaris

  • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

    W.J. Koch;B.E. Hawes;J. Inglese;L.M. Luttrell

  • Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress

    Giovanni Esposito;Antonio Rapacciuolo;Sathyamangla V. Naga Prasad;Hideyuki Takaoka

  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.

    Rui Ping Xiao;Pavel Avdonin;Ying Ying Zhou;Heping Cheng

  • Animal Models of Heart Failure A Scientific Statement From the American Heart Association

    Steven R. Houser;Kenneth B. Margulies;Anne M. Murphy;Francis G. Spinale

Frequent Co-Authors

Erhe Gao
Erhe Gao Temple University
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Steven R. Houser
Steven R. Houser Temple University
Howard A. Rockman
Howard A. Rockman Duke University
Joseph Y. Cheung
Joseph Y. Cheung Temple University
Hugo A. Katus
Hugo A. Katus Heidelberg University
Muniswamy Madesh
Muniswamy Madesh The University of Texas at Austin
Carmelo A. Milano
Carmelo A. Milano Duke University
Donald D. Glower
Donald D. Glower Duke University
Gerald W. Dorn
Gerald W. Dorn Washington University in St. Louis

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