Walter J. Koch focuses on Internal medicine, Endocrinology, Signal transduction, Beta adrenergic receptor kinase and Receptor. His studies deal with areas such as In vivo and Cardiology as well as Internal medicine. His research integrates issues of Calcium-binding protein and Genetically modified mouse in his study of Endocrinology.
His Signal transduction study is concerned with the larger field of Cell biology. Walter J. Koch interconnects Cardiac myocyte, Agonist, G protein-coupled receptor kinase, G alpha subunit and Kinase in the investigation of issues within Beta adrenergic receptor kinase. Walter J. Koch combines subjects such as Stimulation, Neuroscience and Transgene with his study of Receptor.
His primary areas of investigation include Internal medicine, Endocrinology, Heart failure, Receptor and Cell biology. Much of his study explores Internal medicine relationship to Cardiology. His Endocrinology study incorporates themes from Signal transduction, Transgene and Adrenergic receptor.
His research investigates the connection between Heart failure and topics such as Pharmacology that intersect with problems in Reperfusion injury. The Receptor study which covers Kinase that intersects with Phosphorylation. The Beta adrenergic receptor kinase study combines topics in areas such as Cardioprotection and G protein-coupled receptor kinase.
His scientific interests lie mostly in Internal medicine, Heart failure, Cell biology, Receptor and Endocrinology. In his study, which falls under the umbrella issue of Internal medicine, Sympathetic nervous system is strongly linked to Cardiology. The study incorporates disciplines such as Fibrosis, Inflammation and Disease in addition to Heart failure.
Walter J. Koch has included themes like Kinase and Pharmacology in his Receptor study. His Endocrinology research integrates issues from Apoptosis and Protein kinase B. His Beta adrenergic receptor kinase research is multidisciplinary, incorporating elements of Downregulation and upregulation and G protein-coupled receptor kinase.
His main research concerns Internal medicine, Beta adrenergic receptor kinase, Receptor, Heart failure and Endocrinology. He works mostly in the field of Internal medicine, limiting it down to concerns involving Cardiology and, occasionally, Diastole. The various areas that Walter J. Koch examines in his Beta adrenergic receptor kinase study include Protein kinase B and G protein-coupled receptor kinase.
His Receptor research is multidisciplinary, relying on both Immune system, Signal transduction, Pharmacology and Stimulation. His Heart failure research includes themes of Inotrope, Moxonidine, Myocardial infarction and Sympathetic nervous system. His biological study spans a wide range of topics, including Apoptosis and Ischemia.
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Seven-transmembrane-spanning receptors and heart function
Howard A. Rockman;Walter J. Koch;Robert J. Lefkowitz.
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
WJ Koch;HA Rockman;P Samama;RA Hamilton.
A novel protective effect of erythropoietin in the infarcted heart
Cyrus J. Parsa;Akio Matsumoto;Jihee Kim;Ryan U. Riel.
Journal of Clinical Investigation (2003)
Structure and mechanism of the G protein-coupled receptor kinases.
J Inglese;N J Freedman;W J Koch;R J Lefkowitz.
Journal of Biological Chemistry (1993)
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
Howard A. Rockman;Kenneth R. Chien;D. O. N. G. . J. U. Choi;Guido Iaccarino.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Targeting the Receptor-Gq Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
Shahab A. Akhter;Louis M. Luttrell;Howard A. Rockman;Guido Iaccarino.
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
W J Koch;J Inglese;W C Stone;R J Lefkowitz.
Journal of Biological Chemistry (1993)
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
Wei-Zhong Zhu;Ming Zheng;Walter J. Koch;Robert J. Lefkowitz.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras
Walter J. Koch;Brian E. Hawes;Lee F. Allen;Robert J. Lefkowitz.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation
Brian E. Hawes;Tim van Biesen;Walter J. Koch;Louis M. Luttrell.
Journal of Biological Chemistry (1995)
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