D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 90 Citations 33,599 186 World Ranking 1112 National Ranking 664

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Signal transduction
  • G protein-coupled receptor

His main research concerns Cell biology, G protein-coupled receptor, MAPK/ERK pathway, Receptor tyrosine kinase and G protein-coupled receptor kinase. His Cell biology research focuses on Molecular biology and how it relates to Angiotensin II. His G protein-coupled receptor research integrates issues from Mitogen-activated protein kinase, Epidermal growth factor and ASK1.

His study in MAPK/ERK pathway is interdisciplinary in nature, drawing from both Receptor, Second messenger system and Transactivation. Louis M. Luttrell interconnects Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Platelet-derived growth factor receptor and Tyrosine phosphorylation in the investigation of issues within Receptor tyrosine kinase. His G protein study combines topics in areas such as Protein kinase C and Protein kinase A.

His most cited work include:

  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. (1289 citations)
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. (1106 citations)
  • The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals (934 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cell biology, G protein-coupled receptor, Receptor, Signal transduction and Arrestin. His Cell biology study deals with Molecular biology intersecting with Mitogen-activated protein kinase kinase. His G protein-coupled receptor research is multidisciplinary, relying on both 5-HT5A receptor, Neuroscience and Ligand.

While the research belongs to areas of Receptor, Louis M. Luttrell spends his time largely on the problem of Transactivation, intersecting his research to questions surrounding Cancer research and Autocrine signalling. His biological study spans a wide range of topics, including Internalization, Endocrinology and Effector. His work on Beta-Arrestins and Arrestin beta 2 as part of his general Arrestin study is frequently connected to Parathyroid hormone receptor, thereby bridging the divide between different branches of science.

He most often published in these fields:

  • Cell biology (77.03%)
  • G protein-coupled receptor (49.55%)
  • Receptor (40.99%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cell biology (77.03%)
  • G protein-coupled receptor (49.55%)
  • Arrestin (35.59%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cell biology, G protein-coupled receptor, Arrestin, Signal transduction and Receptor. The concepts of his Cell biology study are interwoven with issues in Sphingosine and Internalization. The study incorporates disciplines such as Computational biology, G protein and Phosphorylation in addition to G protein-coupled receptor.

His studies in Arrestin integrate themes in fields like Photochemistry, Signal transducing adaptor protein, In vivo and Functional selectivity. The Receptor study combines topics in areas such as Parathyroid hormone and Kinase. As part of one scientific family, he deals mainly with the area of Arrestin beta 2, narrowing it down to issues related to the Arrestin beta 1, and often Heterotrimeric G protein and Beta-Arrestins.

Between 2013 and 2021, his most popular works were:

  • The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. (186 citations)
  • Fulfilling the Promise of "Biased" G Protein–Coupled Receptor Agonism (134 citations)
  • The conformational signature of β-arrestin2 predicts its trafficking and signalling functions (131 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Signal transduction
  • G protein-coupled receptor

Louis M. Luttrell spends much of his time researching G protein-coupled receptor, Cell biology, Arrestin, Signal transduction and Arrestin beta 2. He has included themes like Receptor and Internalization in his Cell biology study. His studies examine the connections between Receptor and genetics, as well as such issues in Parathyroid hormone, with regards to Ligand, Biochemistry, Intrinsic activity and Molecular biology.

His work in Internalization addresses subjects such as Beta-Arrestins, which are connected to disciplines such as Heterotrimeric G protein and G Protein-Coupled Receptor Signaling. Louis M. Luttrell focuses mostly in the field of Arrestin, narrowing it down to topics relating to Functional selectivity and, in certain cases, Computational biology and Drug discovery. Particularly relevant to G protein is his body of work in Signal transduction.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller.
Science (1999)

1717 Citations

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

Yehia Daaka;Louis M. Luttrell;Robert J. Lefkowitz.
Nature (1997)

1506 Citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

Louis M. Luttrell;Robert J. Lefkowitz;Robert J. Lefkowitz.
Journal of Cell Science (2002)

1328 Citations

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

Louis M. Luttrell;Francine L. Roudabush;Eric W. Choy;William E. Miller.
Proceedings of the National Academy of Sciences of the United States of America (2001)

1108 Citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

Louis M Luttrell;Yehia Daaka;Robert J Lefkowitz.
Current Opinion in Cell Biology (1999)

996 Citations

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

Huijun Wei;Seungkirl Ahn;Sudha K. Shenoy;Sadashiva S. Karnik.
Proceedings of the National Academy of Sciences of the United States of America (2003)

870 Citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

T van Biesen;B E Hawes;D K Luttrell;K M Krueger.
Nature (1995)

779 Citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

Louis M. Luttrell;Brian E. Hawes;Tim van Biesen;Deirdre K. Luttrell.
Journal of Biological Chemistry (1996)

776 Citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

Yehia Daaka;Louis M. Luttrell;Seungkirl Ahn;Gregory J. Della Rocca.
Journal of Biological Chemistry (1998)

648 Citations

Mitogenic Signaling via G Protein-Coupled Receptors

T van Biesen;LM Luttrell;BE Hawes;RJ Lefkowitz.
Endocrine Reviews (1996)

645 Citations

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