Member of the Association of American Physicians
His main research concerns Cell biology, G protein-coupled receptor, MAPK/ERK pathway, Receptor tyrosine kinase and G protein-coupled receptor kinase. His Cell biology research focuses on Molecular biology and how it relates to Angiotensin II. His G protein-coupled receptor research integrates issues from Mitogen-activated protein kinase, Epidermal growth factor and ASK1.
His study in MAPK/ERK pathway is interdisciplinary in nature, drawing from both Receptor, Second messenger system and Transactivation. Louis M. Luttrell interconnects Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Platelet-derived growth factor receptor and Tyrosine phosphorylation in the investigation of issues within Receptor tyrosine kinase. His G protein study combines topics in areas such as Protein kinase C and Protein kinase A.
His scientific interests lie mostly in Cell biology, G protein-coupled receptor, Receptor, Signal transduction and Arrestin. His Cell biology study deals with Molecular biology intersecting with Mitogen-activated protein kinase kinase. His G protein-coupled receptor research is multidisciplinary, relying on both 5-HT5A receptor, Neuroscience and Ligand.
While the research belongs to areas of Receptor, Louis M. Luttrell spends his time largely on the problem of Transactivation, intersecting his research to questions surrounding Cancer research and Autocrine signalling. His biological study spans a wide range of topics, including Internalization, Endocrinology and Effector. His work on Beta-Arrestins and Arrestin beta 2 as part of his general Arrestin study is frequently connected to Parathyroid hormone receptor, thereby bridging the divide between different branches of science.
The scientist’s investigation covers issues in Cell biology, G protein-coupled receptor, Arrestin, Signal transduction and Receptor. The concepts of his Cell biology study are interwoven with issues in Sphingosine and Internalization. The study incorporates disciplines such as Computational biology, G protein and Phosphorylation in addition to G protein-coupled receptor.
His studies in Arrestin integrate themes in fields like Photochemistry, Signal transducing adaptor protein, In vivo and Functional selectivity. The Receptor study combines topics in areas such as Parathyroid hormone and Kinase. As part of one scientific family, he deals mainly with the area of Arrestin beta 2, narrowing it down to issues related to the Arrestin beta 1, and often Heterotrimeric G protein and Beta-Arrestins.
Louis M. Luttrell spends much of his time researching G protein-coupled receptor, Cell biology, Arrestin, Signal transduction and Arrestin beta 2. He has included themes like Receptor and Internalization in his Cell biology study. His studies examine the connections between Receptor and genetics, as well as such issues in Parathyroid hormone, with regards to Ligand, Biochemistry, Intrinsic activity and Molecular biology.
His work in Internalization addresses subjects such as Beta-Arrestins, which are connected to disciplines such as Heterotrimeric G protein and G Protein-Coupled Receptor Signaling. Louis M. Luttrell focuses mostly in the field of Arrestin, narrowing it down to topics relating to Functional selectivity and, in certain cases, Computational biology and Drug discovery. Particularly relevant to G protein is his body of work in Signal transduction.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller.
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
Yehia Daaka;Louis M. Luttrell;Robert J. Lefkowitz.
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
Louis M. Luttrell;Robert J. Lefkowitz;Robert J. Lefkowitz.
Journal of Cell Science (2002)
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Louis M. Luttrell;Francine L. Roudabush;Eric W. Choy;William E. Miller.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
Louis M Luttrell;Yehia Daaka;Robert J Lefkowitz.
Current Opinion in Cell Biology (1999)
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
Huijun Wei;Seungkirl Ahn;Sudha K. Shenoy;Sadashiva S. Karnik.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
T van Biesen;B E Hawes;D K Luttrell;K M Krueger.
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
Louis M. Luttrell;Brian E. Hawes;Tim van Biesen;Deirdre K. Luttrell.
Journal of Biological Chemistry (1996)
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase
Yehia Daaka;Louis M. Luttrell;Seungkirl Ahn;Gregory J. Della Rocca.
Journal of Biological Chemistry (1998)
Mitogenic Signaling via G Protein-Coupled Receptors
T van Biesen;LM Luttrell;BE Hawes;RJ Lefkowitz.
Endocrine Reviews (1996)
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