2026 Hamilton O. Smith: Genetics Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Genetics	77	1727	1643	791	746	149	106618

Research.com Recognitions

1980 - Fellow of the American Academy of Arts and Sciences
1980 - Member of the National Academy of Sciences
1978 - Nobel Prize for the discovery of restriction enzymes and their application to problems of molecular genetics
1975 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Hamilton O. Smith is affiliated with the J. Craig Venter Institute in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology and related subfields.

Smith's recent scholarly work includes the following papers:

Fundamental behaviors emerge from simulations of a living minimal cell, 2022, Cell
PEG Adjustment Enables Genome Transplantation Using Mycoplasma Mycoides Recipient, 2024, bioRxiv (Cold Spring Harbor Laboratory)
Modeling the Lipid Metabolism of a Genetically Minimal Cell, 2020, Biophysical Journal
Modelling the Nucleotide Metabolic Network of a Genetically Minimal Cell, 2020, Biophysical Journal
Modelling the Genetic Information Processes of a Genetically Minimal Cell, 2020, Biophysical Journal

The scientist has collaborated frequently with several coauthors, including:

John I. Glass
Clyde A. Hutchison
David Bianchi
Zaida Luthey-Schulten
Zane R. Thornburg

Smith's work has been published predominantly in the following venues:

Biophysical Journal
Cell
bioRxiv (Cold Spring Harbor Laboratory)
International Journal of Molecular Sciences
Preprints.org

Within their research scope, Smith has addressed a number of key topics, including:

Microbial Metabolic Engineering and Bioproduction
Protein Structure and Dynamics
Bacteriophages and microbial interactions
DNA Repair Mechanisms
Fungal and yeast genetics research
Gene Regulatory Network Analysis
Microbial infections and disease research

Smith has been recognized with several honors throughout their career:

Fellow of the American Academy of Arts and Sciences, 1980
Member of the National Academy of Sciences, 1980
Nobel Prize, 1978, awarded for the discovery of restriction enzymes and their application to problems of molecular genetics
Fellow of John Simon Guggenheim Memorial Foundation, 1975

Best Publications

The Sequence of the Human Genome

J. Craig Venter;Mark D. Adams;Eugene W. Myers;Peter W. Li

22666
Citations
Enzymatic assembly of DNA molecules up to several hundred kilobases

Daniel G Gibson;Lei Young;Ray-Yuan Chuang;J Craig Venter

10542
Citations
The genome sequence of Drosophila melanogaster

M. D. Adams;S. E. Celniker;R. A. Holt;C. A. Evans

8171
Citations
Environmental Genome Shotgun Sequencing of the Sargasso Sea

J. Craig Venter;Karin Remington;John F. Heidelberg;Aaron L. Halpern

5386
Citations
The complete genome sequence of the gastric pathogen Helicobacter pylori

Jean-F. Tomb;Owen White;Anthony R. Kerlavage;Rebecca A. Clayton

4416
Citations
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Daniel G. Gibson;John I. Glass;Carole Lartigue;Vladimir N. Noskov

3342
Citations
The minimal gene complement of Mycoplasma genitalium

Claire M. Fraser;Jeannine D. Gocayne;Owen White;Mark D. Adams

3341
Citations
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

Claire M. Fraser;Sherwood Casjens;Wai Mun Huang;Granger G. Sutton

2665
Citations
The Genome Sequence of the Malaria Mosquito Anopheles gambiae

Robert A. Holt;G. Mani Subramanian;Aaron Halpern;Granger G. Sutton

2637
Citations
The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific

Douglas B. Rusch;Aaron L Halpern;Granger Sutton;Karla B. Heidelberg;Karla B. Heidelberg

2383
Citations
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae

John F. Heidelberg;Jonathan A. Eisen;William C. Nelson;Rebecca A. Clayton

2246
Citations
Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima

Karen E. Nelson;Rebecca A. Clayton;Steven R. Gill;Michelle L. Gwinn

1846
Citations
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans-Peter Klenk;Rebecca A. Clayton;Jean-Francois Tomb;Owen White

1777
Citations
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

H. Tettelin;K. E. Nelson;I. T. Paulsen;Jonathan A Eisen

1696
Citations
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome.

Daniel G. Gibson;Gwynedd A. Benders;Cynthia Andrews-Pfannkoch;Evgeniya A. Denisova

1532
Citations
Design and synthesis of a minimal bacterial genome

Clyde A. Hutchison;Ray Yuan Chuang;Vladimir N. Noskov;Nacyra Assad-Garcia

1460
Citations
Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

Claire M. Fraser;Steven J. Norris;George M. Weinstock;Owen White

1417
Citations
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

Hervé Tettelin;Nigel J. Saunders;John Heidelberg;Alex C. Jeffries

1407
Citations
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.

O. White;J. A. Eisen;J. F. Heidelberg;E. K. Hickey

1251
Citations
A simple method for DNA restriction site mapping

Hamilton O. Smith;Max L. Birnstiel

1249
Citations

Frequent Co-Authors

J. Craig Venter J. Craig Venter Institute

Clyde A. Hutchison J. Craig Venter Institute

John I. Glass J. Craig Venter Institute

Granger G. Sutton J. Craig Venter Institute

Steven L. Salzberg Johns Hopkins University

Claire M. Fraser University of Maryland, Baltimore

Jonathan A. Eisen University of California, Davis

Robert J. Dodson Northwestern University

John F. Heidelberg University of Southern California

Eugene W. Myers Max Planck Institute of Molecular Cell Biology and Genetics

External Links

Personal website of Hamilton O. Smith

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