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Biology and Biochemistry

D-Index
63
Citations
16218
World Ranking
10110
National Ranking
184

Overview

Louis Maes is affiliated with the University of Antwerp in Belgium and has contributed extensively to the field of medicine, with a particular focus on parasitology, organic chemistry, and public health. Their research addresses infectious diseases, especially those caused by protozoan parasites such as Leishmania and Trypanosoma species.

Their recent publications span topics related to drug discovery and pharmacological evaluation targeting neglected tropical diseases. Notable recent papers include:

  • DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis, 2021, Journal of Medicinal Chemistry
  • C6-O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents, 2020, European Journal of Medicinal Chemistry
  • A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation, 2020, Scientific Reports
  • Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections, 2020, Molecules
  • Impact of pulmonary African trypanosomes on the immunology and function of the lung, 2022, Nature Communications

Their research fields include medicine with specific subfields in:

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Organic Chemistry
  • Molecular Biology
  • Parasitology

Main research topics reflect a focus on parasitic diseases and drug development, including:

  • Research on Leishmaniasis Studies
  • Trypanosoma species research and implications
  • Synthesis and Biological Evaluation
  • Parasites and Host Interactions
  • Biochemical and Molecular Research
  • Phosphodiesterase function and regulation
  • HIV/AIDS drug development and treatment

Louis Maes frequently collaborates with other researchers, including:

  • Guy Caljon
  • Sarah Hendrickx
  • An Matheeussen
  • Serge Van Calenbergh
  • Fabian Hulpia

Their work is regularly published in several scientific journals, notably:

  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • ACS Infectious Diseases
  • Molecules
  • ChemMedChem

Best Publications

  • Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.

    Paul Cos;Arnold J. Vlietinck;Dirk Vanden Berghe;Louis Maes;Louis Maes

  • Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

    Gilles Brackman;Paul Cos;Louis Maes;Hans J. Nelis

  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

    Wesley C. Van Voorhis;John H. Adams;Roberto Adelfio;Roberto Adelfio;Vida Ahyong

  • Leishmania-macrophage interactions: insights into the redox biology.

    Tim van Assche;Maartje Deschacht;Raquel A. Inocêncio da Luz;Louis Maes

  • In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences

    Marieke Vermeersch;Raquel Inocêncio da Luz;Kim Toté;Jean-Pierre Timmermans

  • Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

    Koen Jansen;Leen Heirbaut;Robert Verkerk;Jonathan D Cheng

  • Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.

    Koen Jansen;Leen Heirbaut;Jonathan D. Cheng;Jurgen Joossens

  • Advancing drug innovation for neglected diseases-criteria for lead progression.

    Solomon Nwaka;Bernadette Ramirez;Reto Brun;Louis Maes

  • Inhibitory Effect of Biocides on the Viable Masses and Matrices of Staphylococcus aureus and Pseudomonas aeruginosa Biofilms

    K. Toté;T. Horemans;D. Vanden Berghe;L. Maes

  • Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.

    Tim H. M. Jonckers;Sabine van Miert;Kanyanga Cimanga;Christian Bailly

  • Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

    Hideo Imamura;Tim Downing;Tim Downing;Frederik Van den Broeck;Mandy J Sanders

  • Plant substances as anti-HIV agents selected according to their putative mechanism of action

    Paul Cos;Louis Maes;Dirk Vanden Berghe;Nina Hermans

  • Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.

    Sophie Girault;Philippe Grellier;Amaya Berecibar;Louis Maes

  • Structure-Activity Relationship of Cinnamaldehyde Analogs as Inhibitors of AI-2 Based Quorum Sensing and Their Effect on Virulence of Vibrio spp

    Gilles Brackman;Shari Celen;Ulrik Hillaert;Serge Van Calenbergh

  • Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.

    Adina Ryckebusch;Rébecca Deprez-Poulain;Louis Maes;Marie-Ange Debreu-Fontaine

  • Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei.

    Zakaria H. Mbwambo;Modest C. Kapingu;Mainen J. Moshi;Francis Machumi

  • In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo.

    D. Musuyu Muganza;Barbara Fruth;J. Nzunzu Lami;G. K. Mesia

  • Antiprotozoal and cytotoxic screening of 45 plant extracts from Democratic Republic of Congo

    G.K. Mesia;G.L. Tona;T.H. Nanga;R.K. Cimanga;R.K. Cimanga

  • Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.

    Lianet Monzote;Marley García;Jacinta Pastor;Lizette Gil

  • In Vitro and In Vivo Activities of a Triterpenoid Saponin Extract (PX-6518) from the Plant Maesa balansae against Visceral Leishmania Species

    Louis Maes;Dirk Vanden Berghe;Nils Germonprez;Ludo Quirijnen

Frequent Co-Authors

Paul Cos
Paul Cos University of Antwerp
Luc Pieters
Luc Pieters University of Antwerp
Jean-Claude Dujardin
Jean-Claude Dujardin Institute of Tropical Medicine Antwerp
Koen Augustyns
Koen Augustyns University of Antwerp
Arnold J. Vlietinck
Arnold J. Vlietinck University of Antwerp
Harry P. de Koning
Harry P. de Koning University of Glasgow
Vanessa Yardley
Vanessa Yardley London School of Hygiene & Tropical Medicine
Scott G. Franzblau
Scott G. Franzblau University of Illinois at Chicago
William A. Denny
William A. Denny University of Auckland
Iwan J. P. de Esch
Iwan J. P. de Esch Vrije Universiteit Amsterdam

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