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Marina Sironi

Marina Sironi

D-Index & Metrics

Immunology

D-Index
80
Citations
23285
World Ranking
1626
National Ranking
64

Overview

Marina Sironi is affiliated with Humanitas University in Italy and has a research background primarily focused on immunology and microbiology, with a considerable overlap in medicine. Their work spans multiple subfields including immunology, oncology, infectious diseases, molecular biology, and biomedical engineering. Sironi's research also covers a range of topics, highlighting a diverse involvement in areas such as biomarkers in disease mechanisms, immune cells in cancer, cancer immunotherapy and biomarkers, COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, nanoplatforms for cancer theranostics, and the complement system in diseases.

Several recent papers authored or co-authored by Marina Sironi demonstrate their contributions to the understanding of immune responses, particularly related to COVID-19 and cancer immunotherapy:

  • Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy, 2020, Clinical Immunology
  • Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules, 2022, Nature Immunology
  • Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19, 2020, Nature Immunology
  • Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity, 2021, Journal for ImmunoTherapy of Cancer
  • Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions, 2021, Journal of Leukocyte Biology

Marina Sironi frequently collaborates with several researchers in their field, including Alberto Mantovani, Barbara Bottazzi, Cecília Garlanda, Sarah N. Mapelli, and Matteo Stravalaci. These collaborations have contributed to a robust output of scientific publications and interdisciplinary research efforts.

Their research has been published across a variety of prominent venues. The most common publication outlets include Zenodo (CERN European Organization for Nuclear Research), bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Nature Immunology, and the Journal for ImmunoTherapy of Cancer.

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature Immunology
  • Journal for ImmunoTherapy of Cancer

Marina Sironi's work intersects both fundamental and clinical research, particularly in the areas of immune system function and dysfunction in diseases such as cancer and COVID-19. Their research contributions include exploring the function of the complement system, immune cell behavior in cancer environments, and the development of therapeutic strategies against infectious diseases and tumor immunology.

Best Publications

  • Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

    Maria Romano;Marina Sironi;Carlo Toniatti;Nadia Polentarutti

  • Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

    Francesco Colotta;Fabio Re;Marta Muzio;Riccardo Bertini

  • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)

    Subhra K. Biswas;Lisa Gangi;Saki Paul;Tiziana Schioppa

  • Vitamin D3 Affects Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells

    Lorenzo Piemonti;Paolo Monti;Marina Sironi;Paolo Fraticelli

  • Il-1 stimulates il-6 production in endothelial cells

    M Sironi;F Breviario;P Proserpio;A Biondi

  • Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

    Fabio Re;Adriana Zanetti;Marina Sironi;Nadia Polentarutti

  • Glucocorticoids Affect Human Dendritic Cell Differentiation and Maturation

    L Piemonti;P Monti;P Allavena;M Sironi

  • Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines

    F Colotta;N Polentarutti;M Sironi;A Mantovani

  • The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues.

    Silvia Parolini;Amerigo Santoro;Emanuela Marcenaro;Walter Luini

  • Regulation of leukocyte recruitment by the long pentraxin PTX3

    Livija Deban;Remo Castro Russo;Marina Sironi;Federica Moalli

  • Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program

    Marcello Chieppa;Giancarlo Bianchi;Andrea Doni;Annalisa Del Prete

  • The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis.

    Marco Gattorno;Alessandra Piccini;Denise Lasigliè;Sara Tassi

  • Monokine production by microglial cell clones.

    M. Righi;L. Mori;G. De Libero;M. Sironi

  • Inhibition of monocyte chemotactic protein-1 synthesis by statins.

    Maria Romano;Luisa Diomede;Marina Sironi;Lucia Massimiliano

  • Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses

    Paolo Fraticelli;Marina Sironi;Giancarlo Bianchi;Daniele D’Ambrosio

  • Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin

    William Vermi;Elena Riboldi;Valerie Wittamer;Francesca Gentili

  • Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: A molecular basis for priming and synergism with bacterial lipopolysaccharide

    Daniela Bosisio;Nadia Polentarutti;Marina Sironi;Sergio Bernasconi

  • Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.

    Pascale Jeannin;Barbara Bottazzi;Marina Sironi;Andrea Doni

  • Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin

    Francesco Colotta;Francesca L. Sciacca;Marina Sironi;Walter Luini

  • Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

    Cecilia Garlanda;Federica Riva;Nadia Polentarutti;Chiara Buracchi

Frequent Co-Authors

Alberto Mantovani
Alberto Mantovani Humanitas University
Annunciata Vecchi
Annunciata Vecchi Mario Negri Institute for Pharmacological Research
Pietro Ghezzi
Pietro Ghezzi Brighton and Sussex Medical School
Francesco Colotta
Francesco Colotta Mario Negri Institute for Pharmacological Research
Barbara Bottazzi
Barbara Bottazzi Humanitas University
Cecilia Garlanda
Cecilia Garlanda Humanitas University
Nadia Polentarutti
Nadia Polentarutti Humanitas University
Silvano Sozzani
Silvano Sozzani Sapienza University of Rome
Andrea Doni
Andrea Doni Humanitas Research Hospital
Massimo Locati
Massimo Locati University of Milan

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