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Overview

Helmut Klocker is affiliated with Innsbruck Medical University in Austria and has contributed extensively to research in the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including molecular biology, pulmonary and respiratory medicine, oncology, immunology, and cancer research.

The primary focus of Helmut Klocker's research lies in prostate cancer treatment and research, covering clinical, molecular, and diagnostic aspects. Additional research topics include immunotherapy and immune responses, cancer-related molecular pathways, epigenetics and DNA methylation, RNA modifications and cancer, prostate cancer diagnosis and treatment, as well as hormonal and reproductive studies.

They have published several papers in peer-reviewed journals. Notable recent publications include:

  • Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer, 2022, Molecular Cancer
  • OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation, 2020, Nature Communications
  • Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis, 2020, Cell Communication and Signaling
  • STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway, 2023, Molecular Cancer
  • Development and validation of a novel multivariate risk score to guide biopsy decision for the diagnosis of clinically significant prostate cancer, 2020, BJUI Compass

Frequent coauthors in Helmut Klocker's research include:

  • Georg Schäfer
  • Isabel Heidegger
  • Iris E. Eder
  • Wolfgang Horninger
  • Martin Puhr

Helmut Klocker's work has been published repeatedly in several key venues within their field, with notable publication counts in:

  • Cancers
  • European Urology
  • Molecular Cancer
  • Journal of Clinical Investigation
  • bioRxiv (Cold Spring Harbor Laboratory)

The research outputs show a consistent engagement with molecular mechanisms and clinical implications of prostate cancer. This includes studying tumor microenvironments, mitochondrial function, cancer-associated fibroblasts, signaling pathways like mTORC1/CREB, and diagnostic risk scoring models for clinically significant prostate cancer.

Best Publications

  • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor.

    Zoran Culig;Alfred Hobisch;Marcus V. Cronauer;Christian Radmayr

  • Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.

    Z. Culig;A. Hobisch;M. V. Cronauer;A. C. B. Cato

  • Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system

    Z Culig;J Hoffmann;M Erdel;I E Eder

  • Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy

    C. Shad Thaxton;Robert Elghanian;Audrey D. Thomas;Savka I. Stoeva

  • Prostate cancer mortality after introduction of prostate-specific antigen mass screening in the Federal State of Tyrol, Austria.

    Georg Bartsch;Wolfgang Horninger;Helmut Klocker;Andreas Reissigl

  • Regulation of prostatic growth and function by peptide growth factors.

    Zoran Culig;Alfred Hobisch;Marcus V. Cronauer;Christian Radmayr

  • Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

    Claudia Rieser;Günther Böck;Helmut Klocker;Georg Bartsch

  • CELLULAR AND HUMORAL IMMUNE RESPONSES IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AFTER VACCINATION WITH ANTIGEN PULSED DENDRITIC CELLS

    Lorenz Holtl;Claudia Rieser;Christine Papesh;Reinhold Ramoner

  • Prostate-Specific Antigen (PSA) Isoform p2PSA in Combination with Total PSA and Free PSA Improves Diagnostic Accuracy in Prostate Cancer Detection

    Flip H. Jansen;Ron H.N. van Schaik;Joep Kurstjens;Wolfgang Horninger

  • Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia.

    G. Bartsch;R.S. Rittmaster;H. Klocker

  • Androgen receptors in prostate cancer.

    Z Culig;H Klocker;G Bartsch;A Hobisch

  • Circulating Tumor-Specific DNA: A Marker for Monitoring Efficacy of Adjuvant Therapy in Cancer Patients

    Heidi Fiegl;Simone Millinger;Elisabeth Mueller-Holzner;Christian Marth

  • Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205.

    Martin Puhr;Julia Hoefer;Georg Schäfer;Holger H.H. Erb

  • Serum Pro Prostate Specific Antigen Improves Cancer Detection Compared to Free and Complexed Prostate Specific Antigen in Men With Prostate Specific Antigen 2 to 4 Ng/Ml

    William J. Catalona;Georg Bartsch;Harry G. Rittenhouse;Cindy L. Evans

  • Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

    Thomas Putz;Zoran Culig;Iris E. Eder;Claudia Nessler-Menardi

  • SERUM PRO-PROSTATE SPECIFIC ANTIGEN PREFERENTIALLY DETECTS AGGRESSIVE PROSTATE CANCERS IN MEN WITH 2 TO 4 NG/ML PROSTATE SPECIFIC ANTIGEN

    William J. Catalona;Georg Bartsch;Harry G. Rittenhouse;Cindy L. Evans

  • Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue.

    Alfred Hobisch;Hermann Rogatsch;Anton Hittmair;Dietmar Fuchs

  • Inhibition of LncaP prostate cancer cells by means of androgen receptor antisense oligonucleotides.

    Iris E Eder;Zoran Culig;Reinhold Ramoner;Martin Thurnher

  • Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity

    Martin Kerick;Melanie Isau;Melanie Isau;Bernd Timmermann;Holger Sültmann

  • Androgen Receptors in Prostate Cancer

    Zoran Culig;Helmut Klocker;Georg Bartsch;Hannes Steiner

Frequent Co-Authors

Georg Bartsch
Georg Bartsch University of Innsbruck
Peter Boyle
Peter Boyle University of Edinburgh
Chris Robertson
Chris Robertson University of Strathclyde
Eric Maire
Eric Maire Institut National des Sciences Appliquées de Lyon
Ashutosh Tewari
Ashutosh Tewari Icahn School of Medicine at Mount Sinai
Christian W. Huck
Christian W. Huck University of Innsbruck
Bohdan Wasylyk
Bohdan Wasylyk Institute of Genetics and Molecular and Cellular Biology
Ralf Herwig
Ralf Herwig Max Planck Society
Ron H.N. van Schaik
Ron H.N. van Schaik Erasmus University Rotterdam

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