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Molecular Biology

D-Index
69
Citations
16780
World Ranking
1475
National Ranking
747

Overview

Warren D.W. Heston is affiliated with Case Western Reserve University in the United States. Their research spans several interconnected fields focusing on medicine and molecular biology, with significant contributions in oncology and radiology.

Their scholarly output includes papers addressing various aspects of prostate cancer treatment and peptidase inhibition. Notably, they authored a commentary titled Commentary RE: Upregulation of PSMA Following Androgen Deprivation Therapy published in 2020 in the journal Urology.

They have coauthored with several researchers, including Steve S. Huang, Frank P. DiFilippo, Daniel J. Lindner, Zhenghong Lee, and Xinning Wang. Collaboration with these colleagues has resulted in publications predominantly within specialized venues focused on nuclear medicine and molecular imaging.

Frequent publication venues for Warren D.W. Heston include:

  • European Journal of Nuclear Medicine and Molecular Imaging
  • EJNMMI Radiopharmacy and Chemistry
  • Urology

The main fields of study are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these, the subfields most represented in their work are:

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Radiology, Nuclear Medicine and Imaging

The central topics covered in Warren D.W. Heston's research include:

  • Peptidase Inhibition and Analysis
  • Prostate Cancer Treatment and Research
  • Ubiquitin and Proteasome Pathways
  • Neuropeptides and Animal Physiology
  • Chemical Synthesis and Analysis
  • Radiopharmaceutical Chemistry and Applications
  • Hormonal and Reproductive Studies

Recent publications, reflecting ongoing engagement with prostate-specific membrane antigen (PSMA) and related fields, include:

  • GCP III is not the "off-target" for urea-based PSMA ligands, 2023, European Journal of Nuclear Medicine and Molecular Imaging
  • Intriguing information from recent letter and article regarding unwanted targeting of salivary glands by PSMA ligands, 2023, European Journal of Nuclear Medicine and Molecular Imaging
  • A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11, 2024, EJNMMI Radiopharmacy and Chemistry
  • Commentary RE: Upregulation of PSMA Following Androgen Deprivation Therapy, 2020, Urology

Best Publications

  • Prostate-specific membrane antigen expression in normal and malignant human tissues.

    David A. Silver;Inmaculada Pellicer;William R. Fair;Warren D. W. Heston

  • Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

    Unknown

  • Expression of the prostate-specific membrane antigen

    Ron S. Israeli;C. Thomas Powell;John G. Corr;William R. Fair

  • Molecular Cloning of a Complementary DNA Encoding a Prostate-specific Membrane Antigen

    R. S. Israeli;C. T. Powell;W. R. Fair;W. D. W. Heston

  • Prostate-specific membrane antigen is produced in tumor-associated neovasculature.

    Sam S. Chang;Denise S. O’Keefe;Dean J. Bacich;Victor E. Reuter

  • Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen

    Michael C. Gong;Jean Baptiste Latouche;Anja Krause;Warren D W Heston

  • The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy

    Norbert Schülke;Olga A. Varlamova;Gerald P. Donovan;Dangshe Ma

  • Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

    Catherine A. Foss;Ronnie C. Mease;Hong Fan;Yuchuan Wang

  • Alternatively Spliced Variants of Prostate-specific Membrane Antigen RNA: Ratio of Expression as a Potential Measurement of Progression

    S. L. Su;Ih-Ping Huang;W. R. Fair;C. T. Powell

  • A Novel Cytoplasmic Tail MXXXL Motif Mediates the Internalization of Prostate-specific Membrane Antigen

    Sigrid A. Rajasekaran;Gopalakrishnapillai Anilkumar;Eri Oshima;James U. Bowie

  • Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene

    Denise S. O’Keefe;Sai L. Su;Dean J. Bacich;Yutaka Horiguchi

  • Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase.

    Unknown

  • Expression of transforming growth factor α and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue

    Jack H. Mydlo;Joseph Michaeli;Carlos Cordon-Cardo;Alec S. Goldenberg

  • Prostate-Specific Membrane Antigen Regulates Angiogenesis by Modulating Integrin Signal Transduction

    Unknown

  • Molecular pathway for cancer metastasis to bone.

    Sarmishtha De;Juhua Chen;Natalya V. Narizhneva;Warren Heston

  • High energy shock waves suppress tumor growth in vitro and in vivo.

    Paul Russo;Robert A. Stephenson;Carolyn Mies;Robert Huryk

  • Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate.

    Takahito Nakajima;Makoto Mitsunaga;Neil H. Bander;Warren D. Heston

  • Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells.

    C. T. Powell;N. J. Brittis;D. Stec;H. Hug

  • Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinoma

    Sam S Chang;Victor E Reuter;W.D.W Heston;Paul B Gaudin

  • In vitro and in vivo Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-conjugated Antibody to Prostate-specific Membrane Antigen

    Xinning Wang;Dangshe Ma;William C. Olson;Warren D.W. Heston

Frequent Co-Authors

William R. Fair
William R. Fair Memorial Sloan Kettering Cancer Center
Neil H. Bander
Neil H. Bander Cornell University
Victor E. Reuter
Victor E. Reuter Memorial Sloan Kettering Cancer Center
Paul Russo
Paul Russo Memorial Sloan Kettering Cancer Center
Robert H. Silverman
Robert H. Silverman Kent State University
Howard I. Scher
Howard I. Scher Memorial Sloan Kettering Cancer Center
Michel Sadelain
Michel Sadelain Columbia University
Eric A. Klein
Eric A. Klein Cleveland Clinic
Eli Gilboa
Eli Gilboa University of Miami
Peter L. Molloy
Peter L. Molloy Commonwealth Scientific and Industrial Research Organisation

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