His primary scientific interests are in Molecular biology, DNA polymerase, Mitochondrial DNA, Polymerase and DNA polymerase II. The various areas that William C. Copeland examines in his Molecular biology study include Mitochondrial DNA replication, Genome, Biochemistry, DNAJA3 and DNA repair. His research investigates the connection between DNA polymerase and topics such as DNA replication that intersect with problems in Deoxyribonucleoside triphosphate and Heart metabolism.
His work deals with themes such as Mutation, Point mutation and DNA, which intersect with Mitochondrial DNA. William C. Copeland has researched DNA polymerase II in several fields, including DNA polymerase delta and DNA clamp. As part of one scientific family, William C. Copeland deals mainly with the area of DNA clamp, narrowing it down to issues related to the DNA polymerase I, and often Primase.
His primary areas of investigation include Molecular biology, Mitochondrial DNA, DNA polymerase, Polymerase and Genetics. His Molecular biology study which covers Protein subunit that intersects with Specificity factor. His studies deal with areas such as Mutation, Mitochondrion and DNA as well as Mitochondrial DNA.
His DNA polymerase study incorporates themes from DNA polymerase delta, DNA polymerase II, DNA polymerase I and Primer. His DNA polymerase II study combines topics from a wide range of disciplines, such as DNA polymerase mu, DNA clamp and Primase. In his research, Nucleic acid is intimately related to Recombinant baculovirus, which falls under the overarching field of Polymerase.
The scientist’s investigation covers issues in Mitochondrial DNA, Genetics, Mitochondrial disease, Molecular biology and Mitochondrion. His Mitochondrial DNA research incorporates themes from Mutation, Polymerase and DNA polymerase. His DNA polymerase study combines topics in areas such as DNA polymerase delta, DNA clamp, DNA polymerase I and DNA polymerase II.
His work on Exonuclease and Exome sequencing as part of general Genetics research is frequently linked to Table, bridging the gap between disciplines. William C. Copeland interconnects Nucleotide excision repair, DNA repair and DNA replication in the investigation of issues within Molecular biology. His Mitochondrion research integrates issues from Protein subunit, Cerebellar ataxia and Mutagenesis.
William C. Copeland mainly investigates Mitochondrial DNA, Genetics, Mitochondrial disease, Mitochondrion and Mitochondrial DNA replication. His biological study spans a wide range of topics, including Mutation, Molecular biology, Polymerase and DNA polymerase. His DNA polymerase research incorporates elements of Computational biology and DNA damage.
His work in the fields of Genetics, such as Human mitochondrial genetics, Human Phenotype Ontology and Annotation, intersects with other areas such as Data sharing. He combines subjects such as Reactive oxygen species and Epigenetics with his study of Mitochondrion. His work in Mitochondrial DNA replication addresses subjects such as Mitochondrial DNA depletion syndrome, which are connected to disciplines such as Point mutation and Homoplasmy.
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Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective.
William Lewis;Brian J. Day;William C. Copeland.
Nature Reviews Drug Discovery (2003)
Mitochondrial DNA in human malignancy.
John S. Penta;F.M. Johnson;Joseph T. Wachsman;William C. Copeland.
Mutation Research-reviews in Mutation Research (2001)
Eukaryotic DNA polymerases: proposal for a revised nomenclature.
Peter M J Burgers;Eugene V. Koonin;Elspeth Bruford;Luis Blanco.
Journal of Biological Chemistry (2001)
Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase γ
Philip A. Ropp;William C. Copeland.
Inherited mitochondrial diseases of DNA replication.
William C. Copeland.
Annual Review of Medicine (2008)
DNA polymerase gamma in mitochondrial DNA replication and repair.
Maria A. Graziewicz;Matthew J. Longley;William C. Copeland.
Chemical Reviews (2006)
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations
Lee Jun C Wong;Robert K. Naviaux;Nicola Brunetti-Pierri;Qing Zhang.
Human Mutation (2008)
The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit
Matthew J. Longley;Dinh Nguyen;Thomas A. Kunkel;William C. Copeland.
Journal of Biological Chemistry (2001)
Mitochondrial DNA alterations in cancer.
William C. Copeland;Joseph T. Wachsman;F. M. Johnson;John S. Penta.
Cancer Investigation (2002)
The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance
Susan E. Lim;Matthew J. Longley;William C. Copeland.
Journal of Biological Chemistry (1999)
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