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Molecular Biology

D-Index
73
Citations
16254
World Ranking
1290
National Ranking
662

Overview

William C. Copeland is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a total of 58 publications in these areas.

Their work spans several subfields including molecular biology, clinical biochemistry, structural biology, infectious diseases, and surfaces, coatings, and films. Core topics covered in their research are mitochondrial function and pathology, metabolism and genetic disorders, ATP synthase and ATPases research, RNA and protein synthesis mechanisms, DNA repair mechanisms, advanced electron microscopy techniques and applications, and electron and X-ray spectroscopy techniques.

William C. Copeland has published multiple papers, some of which include:

  • Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging, 2020, Genome biology
  • Consequences of compromised mitochondrial genome integrity, 2020, DNA repair
  • Automated systematic evaluation of cryo-EM specimens with SmartScope, 2022, eLife
  • Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors, 2021, Journal of Biological Chemistry
  • Structural insight and characterization of human Twinkle helicase in mitochondrial disease, 2022, Proceedings of the National Academy of Sciences

The frequent co-authors of William C. Copeland include Amanda A. Riccio, Matthew J. Longley, Jonathan Bouvette, Mario J. Borgnia, and Eric D. Sullivan.

Their research has been published frequently in venues such as DNA repair, Journal of Biological Chemistry, Nucleic Acids Research, Molecular Genetics and Metabolism Reports, and Genome biology.

Best Publications

  • Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective.

    William Lewis;Brian J. Day;William C. Copeland

  • Mitochondrial DNA in human malignancy.

    John S. Penta;F.M. Johnson;Joseph T. Wachsman;William C. Copeland

  • Eukaryotic DNA polymerases: proposal for a revised nomenclature.

    Peter M J Burgers;Eugene V. Koonin;Elspeth Bruford;Luis Blanco

  • Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase γ

    Philip A. Ropp;William C. Copeland

  • DNA polymerase gamma in mitochondrial DNA replication and repair.

    Maria A Graziewicz;Matthew J Longley;William C Copeland

  • POLG-related disorders and their neurological manifestations.

    Shamima Rahman;William C Copeland

  • Inherited mitochondrial diseases of DNA replication.

    William C. Copeland

  • Molecular and clinical genetics of mitochondrial diseases due to POLG mutations

    Lee Jun C Wong;Robert K. Naviaux;Nicola Brunetti-Pierri;Qing Zhang

  • The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit.

    Matthew J. Longley;Dinh Nguyen;Thomas A. Kunkel;William C. Copeland

  • Mitochondrial DNA alterations in cancer.

    William C. Copeland;Joseph T. Wachsman;F. M. Johnson;John S. Penta

  • The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

    Susan E. Lim;Matthew J. Longley;William C. Copeland

  • Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia

    Matthew J. Longley;Susanna Clark;Cynthia Yu Wai Man;Gavin Hudson

  • Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ

    Susan E. Lim;William C. Copeland

  • Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

    Matthew J. Longley;Rajendra Prasad;Deepak K. Srivastava;Samuel H. Wilson

  • Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Daniel T. Shaughnessy;Kimberly McAllister;Leroy Worth;Astrid C. Haugen

  • Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity.

    Matthew J. Longley;Philip A. Ropp;Susan E. Lim;William C. Copeland

  • The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase

    Peter Park;William Copeland;Liu Yang;Teresa Wang

  • The mitochondrial DNA polymerase as a target of oxidative damage

    Maria A. Graziewicz;Brian J. Day;William C. Copeland

  • Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency

    Yutaka Nishigaki;Ramon Martí;William C. Copeland;Michio Hirano

  • Mitochondrial disease: clinical aspects, molecular mechanisms, translational science, and clinical frontiers.

    Ben Thornton;Bruce Cohen;William Copeland;Bernard L. Maria

Frequent Co-Authors

Michio Hirano
Michio Hirano Columbia University
Brian J. Day
Brian J. Day National Jewish Health
Robert W. Taylor
Robert W. Taylor Newcastle University
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Karen S. Anderson
Karen S. Anderson Yale University
Samuel H. Wilson
Samuel H. Wilson National Institutes of Health
Joel N. Meyer
Joel N. Meyer Duke University
Rajendra Prasad
Rajendra Prasad Amity University
Lee-Jun C. Wong
Lee-Jun C. Wong Baylor College of Medicine
Salvatore DiMauro
Salvatore DiMauro Columbia University

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