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Molecular Biology

D-Index
45
Citations
5850
World Ranking
2878
National Ranking
1370

Overview

Laurie S. Kaguni is affiliated with Michigan State University in the United States. Their research primarily spans biochemistry, genetics, and molecular biology, with a significant focus on molecular biology as reflected in their publication record.

The scientist's main research topics include:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • Mitochondrial Function and Pathology
  • Genomics and Chromatin Dynamics
  • Lysosomal Storage Disorders Research
  • Sphingolipid Metabolism and Signaling
  • Cellular transport and secretion

Laurie S. Kaguni has contributed to a range of recent scientific papers across multiple publication venues. Notable recent papers are:

  • "Sphingolipid lysosomal storage diseases: from bench to bedside," 2021, published in Lipids in Health and Disease
  • "Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB," 2023, published in Nucleic Acids Research
  • "Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma," 2021, published in Frontiers in Genetics
  • "Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase," 2021, published in Frontiers in Genetics
  • "Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB," 2022, published in bioRxiv (Cold Spring Harbor Laboratory)

The frequent publication venues where Laurie S. Kaguni's research appears include:

  • Frontiers in Genetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • "The Enzymes"
  • UNC Libraries
  • Lipids in Health and Disease

Laurie S. Kaguni collaborates with several coauthors, with some of the most frequent being:

  • Grzegorz L. Ciesielski
  • Johnny Stiban
  • Kateryna Lemishko
  • Rodrigo Crespo-Miguel
  • Thinh Q. Truong

Best Publications

  • DNA polymerase γ, the mitochondrial replicase

    Laurie S. Kaguni

  • Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

    Yuichi Matsushima;Yu Ichi Goto;Laurie S. Kaguni

  • Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons.

    D.L. Lewis;C.L. Farr;L.S. Kaguni

  • Isolation of an intact DNA polymerase-primase from embryos of Drosophila melanogaster.

    Laurie S. Kaguni;Jean-Michel Rossignol;Ronald C. Conaway;I. R. Lehman

  • Functional interactions of mitochondrial DNA polymerase and single-stranded DNA-binding protein. Template-primer DNA binding and initiation and elongation of DNA strand synthesis.

    Carol L. Farr;Yuxun Wang;Laurie S. Kaguni

  • Sequence, organization, and evolution of the A+T region of Drosophila melanogaster mitochondrial DNA.

    David L. Lewis;Carol L. Farr;Aimee L. Farquhar;Laurie S. Kaguni

  • Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome

    Petri T. Luoma;Ningguang Luo;Wolfgang N. Löscher;Carol L. Farr

  • Association of DNA primase with the beta/gamma subunits of DNA polymerase alpha from Drosophila melanogaster embryos.

    L S Kaguni;J M Rossignol;R C Conaway;G R Banks

  • The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp

    Li Fan;Paul C. Sanschagrin;Laurie S. Kaguni;Leslie A. Kuhn

  • Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells.

    Yuichi Matsushima;Rafael Garesse;Laurie S. Kaguni

  • Drosophila mitochondrial transcription factor B1 modulates mitochondrial translation but not transcription or DNA copy number in Schneider cells.

    Yuichi Matsushima;Cristina Adán;Rafael Garesse;Laurie S. Kaguni

  • Mitochondrial Single-stranded DNA-binding Protein Is Required for Mitochondrial DNA Replication and Development in Drosophila melanogaster

    Dieter Maier;Carol L. Farr;Burkhard Poeck;Anuradha Alahari

  • Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme.

    Yuxun Wang;Carol L. Farr;Laurie S. Kaguni

  • Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos.

    Laurie Simon Kaguni;David A. Clayton

  • A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.

    Li Fan;Sangbumn Kim;Carol L. Farr;Kevin T. Schaefer

  • Eukaryotic DNA polymerase-primase: structure, mechanism and function

    Laurie S. Kaguni;I.R. Lehman

  • Mitochondrial Single-stranded DNA-binding Protein from Drosophila Embryos PHYSICAL AND BIOCHEMICAL CHARACTERIZATION

    Pia Thömmes;Carol L. Farr;Richard F. Marton;Laurie S. Kaguni

  • Catalytic Subunit of Mitochondrial DNA Polymerase from Drosophila Embryos CLONING, BACTERIAL OVEREXPRESSION, AND BIOCHEMICAL CHARACTERIZATION

    David L. Lewis;Carol L. Farr;Yuxun Wang;Anthony T. Lagina

  • Matrix proteases in mitochondrial DNA function.

    Yuichi Matsushima;Laurie S. Kaguni

  • The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster

    Balaji Iyengar;Ningguang Luo;Carol L. Farr;Laurie S. Kaguni

Frequent Co-Authors

Howard T. Jacobs
Howard T. Jacobs Tampere University
Anu Suomalainen
Anu Suomalainen University of Helsinki
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill
I. R. Lehman
I. R. Lehman Stanford University
Markku Varjosalo
Markku Varjosalo University of Helsinki
Ronald C. Conaway
Ronald C. Conaway The University of Texas Southwestern Medical Center
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Dongchon Kang
Dongchon Kang Kyushu University
Charles W. Carter
Charles W. Carter University of North Carolina at Chapel Hill
Laurence A. Bindoff
Laurence A. Bindoff Haukeland University Hospital

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