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Massimiliano Bonafè

Massimiliano Bonafè

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
25628
World Ranking
4038
National Ranking
85

Overview

Massimiliano Bonafè is affiliated with the University of Bologna in Italy and has contributed extensively to research at the intersection of medicine and molecular biology. Their scholarly work focuses on understanding the biological mechanisms underpinning aging, inflammation, and disease processes, particularly in relation to COVID-19 and cancer.

The main fields of study covered by their research include Medicine and Biochemistry, Genetics, and Molecular Biology. Within these broad areas, their subfields of investigation span Molecular Biology, Oncology, Immunology, Cancer Research, and Infectious Diseases.

Their research addresses a range of topics, with a notable emphasis on:

  • COVID-19 Clinical Research Studies
  • CAR-T cell therapy research
  • MicroRNA in disease regulation
  • Extracellular vesicles in disease
  • Inflammasome and immune disorders
  • Long-Term Effects of COVID-19
  • Telomeres, Telomerase, and Senescence

Massimiliano Bonafè has contributed several recent papers, including:

  • Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes (2020), published in Cytokine & Growth Factor Reviews
  • miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases (2021), published in Ageing Research Reviews
  • Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells (2020), published in Journal of Extracellular Vesicles
  • Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients (2020), published in Mechanisms of Ageing and Development
  • Sex/gender-related differences in inflammaging (2023), published in Mechanisms of Ageing and Development

Their frequent co-authors include Gianluca Storci, Fabiola Olivieri, Manuela Ferracin, Jacopo Sabbatinelli, and Angelica Giuliani, indicating ongoing collaborations that contribute to their research output.

Publications by Bonafè have appeared repeatedly in journals such as Ageing Research Reviews and Mechanisms of Ageing and Development, each with five publications, as well as in Frontiers in Immunology, Haematologica, and Cancer Research, each accounting for three publications.

Best Publications

  • Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

    Claudio Franceschi;Massimiliano Bonafè;Silvana Valensin;Fabiola Olivieri

  • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

    Pasquale Sansone;Gianluca Storci;Simona Tavolari;Tiziana Guarnieri

  • Bone Marrow Cells Differentiate in Cardiac Cell Lineages After Infarction Independently of Cell Fusion

    Jan Kajstura;Marcello Rota;Brian Whang;Stefano Cascapera

  • Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

    Pasquale Sansone;Claudia Savini;Ivana Kurelac;Qing Chang

  • Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

    Michelangela Barbieri;Massimiliano Bonafè;Claudio Franceschi;Giuseppe Paolisso

  • Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

    Claudio Franceschi;Massimiliano Bonafè;Silvana Valensin

  • The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

    Qing Chang;Eirini Bournazou;Pasquale Sansone;Marjan Berishaj

  • Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans

    G. De Benedictis;G. Rose;G. Carrieri;M. De Luca

  • Centenarians as a model for healthy aging

    C. Franceschi;M. Bonafè

  • The network and the remodeling theories of aging: historical background and new perspectives

    C Franceschi;S Valensin;M Bonafè;G Paolisso

  • Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

    Michelangela Barbieri;Luigi Ferrucci;Emilia Ragno;Annamaria Corsi

  • A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.

    Massimiliano Bonafè;Fabiola Olivieri;Luca Cavallone;Simona Giovagnetti

  • Variability of the SIRT3 gene, human Silent Information Regulator Sir2 homologue, and survivorship in the elderly

    Giuseppina Rose;Serena Dato;K. Altomare;Dina Bellizzi

  • Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE).

    C. Franceschi;L. Motta;S. Valensin;R. Rapisarda

  • Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.

    Massimiliano Bonafè;Michelangela Barbieri;Francesca Marchegiani;Fabiola Olivieri

  • Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner.

    Adam W. Studebaker;Gianluca Storci;Jillian L. Werbeck;Pasquale Sansone

  • Gender-specific association between -1082 IL-10 promoter polymorphism and longevity.

    D Lio;L Scola;A Crivello;G Colonna-Romano

  • Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP

    D Lio;L Scola;A Crivello;G Colonna-Romano

  • p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres.

    Pasquale Sansone;Gianluca Storci;Catia Giovannini;Silvia Pandolfi

  • Do men and women follow different trajectories to reach extreme longevity

    C. Franceschi;L. Motta;S. Valensin;R. Rapisarda

Frequent Co-Authors

Claudio Franceschi
Claudio Franceschi University of Bologna
Fabiola Olivieri
Fabiola Olivieri Marche Polytechnic University
Daniela Monti
Daniela Monti University of Florence
Anatoli I. Yashin
Anatoli I. Yashin Duke University
Stefano Salvioli
Stefano Salvioli University of Bologna
Antonio Procopio
Antonio Procopio Marche Polytechnic University
Giuseppe Paolisso
Giuseppe Paolisso University of Campania "Luigi Vanvitelli"
David Lyden
David Lyden Cornell University
Miriam Capri
Miriam Capri University of Bologna
Luigi Ferrucci
Luigi Ferrucci National Institutes of Health

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