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Derek G. Doherty

Derek G. Doherty

D-Index & Metrics

Immunology

D-Index
48
Citations
9849
World Ranking
4415
National Ranking
10

Overview

Derek G. Doherty is affiliated with Trinity College Dublin in Ireland and has a research focus spanning medicine and immunology and microbiology. Their work is concentrated on immunology, oncology, neurology, epidemiology, and infectious diseases, with particular attention to immune cell function and interaction, immune response and inflammation, and long-term effects of COVID-19.

They have contributed to research on cancer immunotherapy and biomarkers, liver disease diagnosis and treatment, IL-33, ST2, and ILC pathways, as well as CAR-T cell therapy research. These topics reflect an interdisciplinary approach across immunological mechanisms, disease pathology, and therapeutic development.

Doherty has frequently published in the following venues:

  • Frontiers in Immunology
  • Clinical Immunology
  • Frontiers in Pediatrics
  • Alimentary Pharmacology & Therapeutics
  • Hepatology

Their recent notable papers include:

  • "Immune Dysregulation in Children With Down Syndrome," 2020, Frontiers in Pediatrics
  • "Improvement in histological endpoints of MAFLD following a 12-week aerobic exercise intervention," 2020, Alimentary Pharmacology & Therapeutics
  • "Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry," 2021, Hepatology
  • "Characterisation of the pro-inflammatory cytokine signature in severe COVID-19," 2023, Frontiers in Immunology
  • "Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy," 2021, Journal of Neuroimmunology

Derek G. Doherty often collaborates with co-authors including Ashanty M. Melo, Eleanor J. Molloy, Margaret R. Dunne, Aideen Long, and Nawal A. B. Taher, indicating active collaboration within their research community.

Best Publications

  • Autoimmune hepatitis in childhood : A 20-year experience

    G V Gregorio;B Portmann;F Reid;P T Donaldson

  • Innate and adaptive lymphoid cells in the human liver

    Derek G. Doherty;Cliona O'Farrelly

  • Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes

    Suzanne Norris;Clive Collins;Derek G. Doherty;Fiona Smith

  • Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors.

    Peter T. Donaldson;Derek G. Doherty;Karen M. Hayllar;Ian G. McFarlane

  • The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

    Derek G. Doherty;Suzanne Norris;Laura Madrigal-Estebas;Gerry McEntee

  • Immunity, tolerance and autoimmunity in the liver: A comprehensive review.

    Derek G. Doherty

  • Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity

    Lydia Lynch;Donal O'Shea;Desmond C. Winter;Justin Geoghegan

  • Defining the outcome of immunosuppression withdrawal after liver transplantation

    John Devlin;Derek Doherty;Linda Thomson;Terence Wong

  • Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis

    Derek G. Doherty;Peter T. Donaldson;James A. Underhill;J. Mark Farrant

  • NKT Cells from Normal and Tumor-Bearing Human Livers Are Phenotypically and Functionally Distinct from Murine NKT Cells

    Tony Kenna;Lucy Golden Mason;Steven A. Porcelli;Yasuhiko Koezuka

  • Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15

    Jean Dunne;Sara Lynch;Cliona O’Farrelly;Stephen Todryk

  • Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis

    A. E. Hogan;A. M. Tobin;T. Ahern;M. A. Corrigan

  • Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

    Suzanne Norris;Derek G. Doherty;Derek G. Doherty;Clive Collins;Gerry McEntee

  • Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

    Eirin Carolan;Laura M. Tobin;Bozgana A. Mangan;Michelle Corrigan

  • Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells

    Bozgana A. Mangan;Margaret R. Dunne;Vincent P. O’Reilly;Pádraic J. Dunne

  • Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure

    Lucy Golden-Mason;Laura Madrigal-Estebas;Emma McGrath;Melissa J Conroy

  • Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver.

    Tony Kenna;Lucy Golden-Mason;Suzanne Norris;John E. Hegarty

  • Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis

    J. Mark Farrant;Derek G. Doherty;Peter T. Donaldson;Robert W. Vaughan

  • Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro.

    Jane Kelly-Rogers;Laura Madrigal-Estebas;Tony O’Connor;Derek G. Doherty

  • Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease

    Margaret R. Dunne;Margaret R. Dunne;Louise Elliott;Seamus Hussey;Nasir Mahmud

  • Decrease in hepatic CD56+ T cells and Vα24+ natural killer T cells in chronic hepatitis C viral infection

    Tina Deignan;Michael P Curry;Derek G Doherty;Lucy Golden-Mason

Frequent Co-Authors

Cliona O'Farrelly
Cliona O'Farrelly Trinity College Dublin
Peter T. Donaldson
Peter T. Donaldson University of Newcastle Australia
Lucy Golden-Mason
Lucy Golden-Mason University of Southern California
Roger Williams
Roger Williams Foundation for Liver Research
Thomas J. Ryan
Thomas J. Ryan Cincinnati Children's Hospital Medical Center
Dermot Kelleher
Dermot Kelleher University of British Columbia
Giorgina Mieli-Vergani
Giorgina Mieli-Vergani King's College London
Conleth Feighery
Conleth Feighery Trinity College Dublin
Steven A. Porcelli
Steven A. Porcelli Albert Einstein College of Medicine
Mark A. Exley
Mark A. Exley Brigham and Women's Hospital

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