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Molecular Biology

D-Index
63
Citations
19376
World Ranking
1785
National Ranking
144

Overview

Ivan Gout is affiliated with University College London in the United Kingdom and has produced research primarily in the field of Biochemistry, Genetics, and Molecular Biology with a focus on molecular biology and related subfields. Their scientific contributions cover various topics, including neurological diseases and metabolism, porphyrin metabolism and disorders, metabolism and genetic disorders, mitochondrial function and pathology, mechanisms of cancer metastasis, RNA modifications and cancer, and cancer-related gene regulation.

Their recent publication record includes papers that address biochemical regulation and redox biology. Notable recent works include:

  • The Writers, Readers, and Erasers in Redox Regulation of GAPDH (2020, Antioxidants)
  • Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A (2021, Redox Biology)
  • Regulation of the CoA Biosynthetic Complex Assembly in Mammalian Cells (2021, International Journal of Molecular Sciences)
  • Low-molecular-weight thiol transferases in redox regulation and antioxidant defence (2024, Redox Biology)
  • Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A (2023, BBA Advances)

Ivan Gout's collaborations include repeated partnerships with several coauthors, reflecting ongoing research relationships in their field. Frequent collaborators include:

  • Valeriy Filonenko
  • Maria-Armineh Tossounian
  • Bess Yi Kun Yu
  • Sew-Yeu Peak-Chew
  • Mark Skehel

Their research output is often published in specialized venues that focus on redox biology, molecular sciences, and free radical research. The most frequent publication venues for their work are:

  • Free Radical Biology and Medicine
  • International Journal of Molecular Sciences
  • Antioxidants
  • Redox Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Ivan Gout's research interests span a range of biochemical and neurological conditions, emphasizing cellular metabolism and molecular regulatory mechanisms. The repeated focus on redox regulation, coenzyme A metabolism, and related cellular processes indicates a specialized niche within molecular biology addressing both fundamental and applied biomedical questions.

Best Publications

  • PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS

    Pablo Rodriguez-Viciana;Patricia H. Warne;Ritu Dhand;Bart Vanhaesebroeck

  • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

    Laura S Harrington;Greg M Findlay;Alexander Gray;Tatiana Tolkacheva

  • Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.

    Masayuki Otsu;Ian Hiles;Ivan Gout;Michael J. Fry

  • Phosphatidylinositol 3-kinase : structure and expression of the 110 kd catalytic subunit

    Ian D. Hiles;Masayuki Otsu;Stefano Volinia;Michael J. Fry

  • A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

    Elisabeth Stockert;Elke Jäger;Yao-Tseng Chen;Matthew J. Scanlan

  • Phospholipase D: a downstream effector of ARF in granulocytes

    Shamshad Cockcroft;Geraint M. H. Thomas;Amanda Fensome;Blandine Geny

  • Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

    K Salim;M J Bottomley;E Querfurth;M J Zvelebil

  • The GTPase dynamin binds to and is activated by a subset of SH3 domains.

    Ivan Gout;Ritu Dhand;Ian D. Hiles;Michael J. Fry

  • PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

    R Dhand;I Hiles;G Panayotou;S Roche

  • Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

    Andrew M. Scharenberg;Ousama El-Hillal;David A. Fruman;Laurie O. Beitz

  • PI 3-kinase: structural and functional analysis of intersubunit interactions.

    Ritu Dhand;K. Hara;I. Hiles;B. Bax

  • Functions and regulation of the 70kDa ribosomal S6 kinases.

    Tim R. Fenton;Ivan T. Gout;Ivan T. Gout

  • Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

    Matthew J. Scanlan;Ivan Gout;Claudia M. Gordon;Barbara Williamson

  • Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of phosphatidylinositol 3-kinase

    Grant W. Booker;Ivan Gout;A. Kristina^Downing;Paul C. Driscoll

  • FGF‐2 protects small cell lung cancer cells from apoptosis through a complex involving PKCε, B‐Raf and S6K2

    Olivier E Pardo;Olivier E Pardo;Claudia Wellbrock;Umme K Khanzada;Muriel Aubert

  • Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

    G Panayotou;G Gish;P End;O Truong

  • Exome Sequence Reveals Mutations in CoA Synthase as a Cause of Neurodegeneration with Brain Iron Accumulation

    Sabrina Dusi;Lorella Valletta;Tobias B. Haack;Yugo Tsuchiya

  • Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.

    G.W Booker;A.L Breeze;A.K Downing;G Panayotou

  • Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.

    Ivan Gout;Ivan Gout;Taichi Minami;Kenta Hara;Yosuke Tsujishita

  • An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

    Peter Finan;Yazuaki Shimizu;Ivan Gout;Justin Hsuan

Frequent Co-Authors

Michael D. Waterfield
Michael D. Waterfield Ludwig Cancer Research
Mike Waterfield
Mike Waterfield Ludwig Cancer Research
George Panayotou
George Panayotou Ludwig Cancer Research
Stefano Volinia
Stefano Volinia University of Ferrara
Peter J. Parker
Peter J. Parker The Francis Crick Institute
Vladimir L. Buchman
Vladimir L. Buchman Cardiff University
J. Justin Hsuan
J. Justin Hsuan University College London
Nicholas F. Totty
Nicholas F. Totty Ludwig Cancer Research
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Rainer Cramer
Rainer Cramer University of Reading

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