World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
80
Citations
23520
World Ranking
3411
National Ranking
192

Molecular Biology

D-Index
90
Citations
30759
World Ranking
734
National Ranking
58

Research.com Recognitions

  • 1993 - Fellow of the Royal Society of Edinburgh

Overview

Tom Brown is affiliated with the University of Oxford in the United Kingdom and focuses their research primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans a variety of subfields, with a substantial emphasis on Molecular Biology, Artificial Intelligence, Electrical and Electronic Engineering, Organic Chemistry, and Genetics.

The scientist has contributed to a range of topics within their field, notably:

  • Advanced biosensing and bioanalysis techniques
  • DNA and Nucleic Acid Chemistry
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Click Chemistry and Applications
  • Topic Modeling
  • Integrated Energy Systems Optimization

Tom Brown has published extensively, including recent papers such as:

  • "A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids" (2021, Chemical Reviews)
  • "Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedback" (2022, arXiv (Cornell University))
  • "Constitutional AI: Harmlessness from AI Feedback" (2022, arXiv (Cornell University))
  • "Predictability and Surprise in Large Generative Models" (2022, 2022 ACM Conference on Fairness, Accountability, and Transparency)
  • "Language Models (Mostly) Know What They Know" (2022, arXiv (Cornell University))

The venues in which Tom Brown frequently publishes include:

  • arXiv (Cornell University)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Nature Communications
  • Journal of the American Chemical Society

Collaborations feature prominently in Brown's research, with frequent co-authors including:

  • Afaf H. El-Sagheer (48 joint publications)
  • Fabian Neumann (13 joint publications)
  • Dawn Drain (12 joint publications)
  • Nelson Elhage (12 joint publications)
  • Tom Henighan (12 joint publications)

Tom Brown was recognized with the fellowship of the Royal Society of Edinburgh in 1993, reflecting a noteworthy milestone in their career.

Best Publications

  • Detection of PCR products using self-probing amplicons and fluorescence.

    David Whitcombe;Jane Theaker;Simon P. Guy;Tom Brown

  • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway.

    Barbara A. Hocevar;Thomas L. Brown;Philip H. Howe

  • Click chemistry with DNA

    Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation

    Hak-Ling Ma;Spencer Liang;Jing Li;Lee Napierata

  • One-to-one technology-enhanced learning: An opportunity for global research collaboration

    Tak-Wai Chan;Jeremy Roschelle;Sherry Hsi;Kinshuk Kinshuk

  • Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L

    Aimin Zhou;Aimin Zhou;Jayashree Paranjape;Thomas L. Brown;Huiqin Nie

  • The structural basis of specific base-excision repair by uracil–DNA glycosylase

    Renos Savva;Katherine McAuley-Hecht;Tom Brown;Laurence Pearl

  • Mode of action and application of Scorpion primers to mutation detection.

    Nicola Thelwell;Stephen Millington;Antonio Solinas;James Booth

  • Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties

    Tina M. Caserta;A. N. Smith;Amy D. Gultice;M. A. Reedy

  • Common Severe Infections in Chronic Granulomatous Disease

    Beatriz E. Marciano;Christine Spalding;Alan Fitzgerald;Daphne Mann

  • A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.

    Nicolò Zuin Fantoni;Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • A genotype of hepatitis D virus that occurs in northern South America.

    J L Casey;T L Brown;E J Colan;F S Wignall

  • Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair

    William N. Hunter;Tom Brown;Tom Brown;Naveen N. Anand;Olga Kennard

  • Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.

    Ravindra Kumar;Afaf El-Sagheer;John Tumpane;Per Lincoln

  • Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase: Mismatch Recognition by Complementary-Strand Interactions

    Tracey E Barrett;Renos Savva;George Panayotou;Tom Barlow

  • Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs.

    Katherine E. McAuley-Hecht;Gordon A. Leonard;Neil J. Gibson;James B. Thomson

  • Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology

    Afaf H. El-Sagheer;Tom Brown

  • Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection.

    B. J. Aronow;S. D. Lund;T. L. Brown;J. A. K. Harmony

  • The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.

    W.N. Hunter;T. Brown;G. Kneale;N.N. Anand

  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.

    Laura L. Carter;Michael W. Leach;Mihai L. Azoitei;Junqing Cui

  • Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    P Horby;M Mafham;L Peto

  • Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    Peter W Horby;Lise Estcourt;Leon Peto

Frequent Co-Authors

Afaf H. El-Sagheer
Afaf H. El-Sagheer University of Southampton
Keith R. Fox
Keith R. Fox University of Southampton
Andrew N. Lane
Andrew N. Lane University of Kentucky
Bengt Nordén
Bengt Nordén Chalmers University of Technology
Bo Albinsson
Bo Albinsson Chalmers University of Technology
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Per Lincoln
Per Lincoln Chalmers University of Technology
Philip N. Bartlett
Philip N. Bartlett University of Southampton
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Otto L. Muskens
Otto L. Muskens University of Southampton

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