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Biology and Biochemistry

D-Index
79
Citations
45834
World Ranking
4194
National Ranking
2052

Overview

Gregory J. Pazour is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a significant concentration in Molecular Biology and Genetics. The scientist's work spans a range of subfields including Cell Biology, Pathology and Forensic Medicine, and Surgery.

The major topics addressed in Pazour's research include Genetic and Kidney Cyst Diseases, Renal and related cancers, Hedgehog Signaling Pathway Studies, Protist diversity and phylogeny, Genetic Syndromes and Imprinting, Biomedical Research and Pathophysiology, and Epigenetics and DNA Methylation.

Recent publications by Gregory J. Pazour highlight contributions to understanding cellular mechanisms and signaling pathways. These include:

  • Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling, 2020, The Journal of Cell Biology
  • Consensus nomenclature for dyneins and associated assembly factors, 2022, The Journal of Cell Biology
  • A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation, 2022, EMBO Reports
  • E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened, 2021, The Journal of Cell Biology
  • Rab34 is necessary for early stages of intracellular ciliogenesis, 2021, Current Biology

Frequent coauthors in Pazour's work include Michael W. Stuck, Julie A. Jonassen, Abigail O. Smith, Kenley M. Preval, and Thibaut Eguether.

Pazour's research findings have been published in multiple venues, with notable contributions in bioRxiv (Cold Spring Harbor Laboratory), The Journal of Cell Biology, PLoS Genetics, Journal of Cell Science, and PLoS Biology.

Best Publications

  • Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

    Michiru Nishita;Seung-Yeol Park;Tadashi Nishio;Koki Kamizaki

  • The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions

    Sabeeha S. Merchant;Simon E. Prochnik;Olivier Vallon;Elizabeth H. Harris

  • The Genome of the Diatom Thalassiosira Pseudonana: Ecology, Evolution, and Metabolism

    E. Virginia Armbrust;John A. Berges;Chris Bowler;Beverley R. Green

  • Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella

    Gregory J. Pazour;Bethany L. Dickert;Yvonne Vucica;E. Scott Seeley

  • Proteomic analysis of a eukaryotic cilium

    Gregory J. Pazour;Nathan S. Agrin;John D. Leszyk;George B. Witman

  • The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation

    Brian Palenik;Jane Grimwood;Andrea Aerts;Pierre Rouzé

  • PDGFRαα signaling is regulated through the primary cilium in fibroblasts

    Linda Schneider;Christian A. Clement;Stefan C. Teilmann;Gregory J. Pazour

  • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

    Gregory J. Pazour;Jovenal T. San Agustin;John A. Follit;Joel L. Rosenbaum

  • A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.

    Zhaoxia Sun;Adam Amsterdam;Gregory J. Pazour;Douglas G. Cole

  • The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance.

    Gregory J. Pazour;Sheila A. Baker;James A. Deane;Douglas G. Cole

  • The vertebrate primary cilium is a sensory organelle.

    Gregory J Pazour;George B Witman

  • The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly

    Gregory J. Pazour;Bethany L. Dickert;George B. Witman

  • The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly

    John A. Follit;Richard A. Tuft;Kevin E. Fogarty;Gregory J. Pazour

  • A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)

    Gregory J. Pazour;Curtis G. Wilkerson;George B. Witman

  • Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

    You Li;Nikolai T Klena;George C Gabriel;Xiaoqin Liu

  • The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

    Karl-Ferdinand Lechtreck;Eric C. Johnson;Tsuyoshi Sakai;Deborah A. Cochran

  • Intraflagellar transport and cilia-dependent diseases.

    Gregory J Pazour;Joel L Rosenbaum

  • Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.

    Francesca Finetti;Silvia Rossi Paccani;Maria Giovanna Riparbelli;Emiliana Giacomello

  • Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

    Ming Ma;Xin Tian;Peter Igarashi;Gregory J Pazour

  • Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella

    Yuqing Hou;Hongmin Qin;John A. Follit;Gregory J. Pazour

Frequent Co-Authors

George B. Witman
George B. Witman University of Massachusetts Chan Medical School
Cecilia W. Lo
Cecilia W. Lo University of Pittsburgh
Stephen M. King
Stephen M. King University of Connecticut Health Center
Joel L. Rosenbaum
Joel L. Rosenbaum Yale University
Rex A. Hess
Rex A. Hess University of Illinois at Urbana-Champaign
Joseph C. Besharse
Joseph C. Besharse Medical College of Wisconsin
Ritsu Kamiya
Ritsu Kamiya University of Tokyo
Daniel S. Rokhsar
Daniel S. Rokhsar University of California, Berkeley
Søren T. Christensen
Søren T. Christensen University of Copenhagen
Chris Bowler
Chris Bowler École Normale Supérieure

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