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Michel R. Leroux

Michel R. Leroux

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
17107
World Ranking
8169
National Ranking
284

Overview

Michel R. Leroux is affiliated with Simon Fraser University in Canada and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research encompasses several interconnected subfields, including genetics, molecular biology, cell biology, pulmonary and respiratory medicine, and pediatrics, perinatology, and child health.

Their recent publications cover a range of topics related to cilia, cellular structures, and genetic disease mechanisms. Notable papers include:

  • Composition, organization and mechanisms of the transition zone, a gate for the cilium, 2022, EMBO Reports
  • The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms, 2020, The American Journal of Human Genetics
  • CDKL kinase regulates the length of the ciliary proximal segment, 2021, Current Biology
  • Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport, 2020, Current Biology
  • The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision, 2022, Nature Communications

Leroux's main research topics include genetic and kidney cyst diseases, protist diversity and phylogeny, microtubule and mitosis dynamics, advanced breast cancer therapies, epigenetics and DNA methylation, genomics and rare diseases, and genomic variations and chromosomal abnormalities.

Frequent coauthors they have collaborated with are Chunmei Li, Kwangjin Park, João Gonçalves, Laurence Pelletier, and Peter Canning. This network of collaborators reflects interdisciplinary efforts in molecular and cell biology research.

Their work has been published in venues such as Zenodo (CERN European Organization for Nuclear Research), The American Journal of Human Genetics, Current Biology, Scientific Reports, and EMBO Reports, indicating an engagement with both specialized and broader scientific communities.

Best Publications

  • Genes and molecular pathways underpinning ciliopathies

    Jeremy F. Reiter;Michel R. Leroux

  • Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene

    Jin Billy Li;Jantje M Gerdes;Courtney J Haycraft;Yanli Fan

  • Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome

    Stephen J. Ansley;Jose L. Badano;Oliver E. Blacque;Josephine Hill

  • The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

    John A. Sayer;John A. Sayer;Edgar A. Otto;John F. O'Toole;Gudrun Nurnberg

  • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

    Alison J Ross;Helen May-Simera;Erica R Eichers;Masatake Kai

  • The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

    Jeremy F Reiter;Oliver E Blacque;Michel R Leroux

  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression

    Jun Chul Kim;Jose L Badano;Sonja Sibold;Muneer A Esmail

  • Functional coordination of intraflagellar transport motors

    Guangshuo Ou;Oliver E. Blacque;Joshua J. Snow;Michel R. Leroux

  • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

    Oliver E. Blacque;Michael J. Reardon;Chunmei Li;Jonathan McCarthy

  • MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

    Corey L. Williams;Chunmei Li;Katarzyna Kida;Peter N. Inglis

  • Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.

    Yanli Fan;Muneer A Esmail;Stephen J Ansley;Oliver E Blacque

  • Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.

    Ralf Siegert;Michel R. Leroux;Clemens Scheufler;F.Ulrich Hartl

  • Functional Genomics of the Cilium, a Sensory Organelle

    Oliver E. Blacque;Elliot A. Perens;Keith A. Boroevich;Peter N. Inglis

  • Structure-Function Studies on Small Heat Shock Protein Oligomeric Assembly and Interaction with Unfolded Polypeptides

    Michel R. Leroux;Ronald Melki;Bruce Gordon;Gérard Batelier

  • Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans

    Jan Halbritter;Albane A. Bizet;Miriam Schmidts;Jonathan D. Porath

  • The sensory cilia of Caenorhabditis elegans.

    Peter N. Inglis;Guangshuo Ou;Michel R. Leroux;Jonathan M. Scholey

  • Piecing together a ciliome.

    Peter N. Inglis;Keith A. Boroevich;Michel R. Leroux

  • Compartmentation of protein folding in vivo: sequestration of non‐native polypeptide by the chaperonin–GimC system

    Katja Siegers;Thomas Waldmann;Michel R. Leroux;Katrin Grein

  • The roles of evolutionarily conserved functional modules in cilia-related trafficking

    Ching-Hwa Sung;Michel R. Leroux

  • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

    A Ross;H May-Simera;E Eichers;M Kai

Frequent Co-Authors

Oliver E. Blacque
Oliver E. Blacque University College Dublin
Nicholas Katsanis
Nicholas Katsanis Galatea Bio Inc
Philip L. Beales
Philip L. Beales University College London
Jonathan M. Scholey
Jonathan M. Scholey University of California, Davis
David L. Baillie
David L. Baillie Simon Fraser University
Erica E. Davis
Erica E. Davis Lurie Children's Hospital
Bradley K. Yoder
Bradley K. Yoder University of Alabama at Birmingham
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
F. Ulrich Hartl
F. Ulrich Hartl Max Planck Society
Jeremy F. Reiter
Jeremy F. Reiter University of California, San Francisco

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