Michel R. Leroux spends much of his time researching Cell biology, Cilium, Basal body, Intraflagellar transport and Ciliary transition zone. His work deals with themes such as Translation, Genetics, Protein biosynthesis and Folding, which intersect with Cell biology. He has researched Cilium in several fields, including Flagellum, Microtubule, BBSome and Ciliopathies, Ciliary base.
His research integrates issues of Computational biology, Ciliopathy and Bioinformatics in his study of Ciliopathies. His studies in Basal body integrate themes in fields like Bardet–Biedl syndrome, Centriole, Dynactin, Ciliogenesis and Axoneme. He combines subjects such as Caenorhabditis elegans and Cell polarity with his study of Bardet–Biedl syndrome.
The scientist’s investigation covers issues in Cell biology, Cilium, Intraflagellar transport, Caenorhabditis elegans and Genetics. His Cell biology research is multidisciplinary, incorporating elements of Axoneme and Flagellum. His research in Cilium intersects with topics in Ciliary transition zone, Ciliopathies, Basal body and Ciliopathy.
His studies deal with areas such as Centriole and Zebrafish as well as Basal body. As part of the same scientific family, Michel R. Leroux usually focuses on Intraflagellar transport, concentrating on Axoplasmic transport and intersecting with Dynein. His work is dedicated to discovering how Caenorhabditis elegans, Function are connected with Heat shock protein and Sensory system and other disciplines.
Cilium, Cell biology, Intraflagellar transport, Ciliopathy and Phenotype are his primary areas of study. His Cilium study integrates concerns from other disciplines, such as Ciliary transition zone, Ciliopathies and Cell signaling. His Ciliary transition zone study combines topics from a wide range of disciplines, such as MKS complex and RPGRIP1L.
His biological study spans a wide range of topics, including Basal body, Caenorhabditis elegans and Compartment. His work carried out in the field of Intraflagellar transport brings together such families of science as Axoneme, Dynein, Kinesin and Axoplasmic transport. His work deals with themes such as Mutation, Germline, Genomics, Histone and Computational biology, which intersect with Phenotype.
Michel R. Leroux mostly deals with Cilium, Intraflagellar transport, Cell biology, Ciliogenesis and Genetics. His study in Cilium is interdisciplinary in nature, drawing from both Ciliary transition zone and Basal body. The concepts of his Intraflagellar transport study are interwoven with issues in Ciliopathies and Microtubule.
Michel R. Leroux specializes in Cell biology, namely Signal transduction. His Ciliogenesis research includes themes of Ciliopathy and BBSome. In the subject of general Genetics, his work in MKS complex is often linked to Ciliary Motility Disorders, thereby combining diverse domains of study.
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Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene
Jin Billy Li;Jantje M Gerdes;Courtney J Haycraft;Yanli Fan.
Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome
Stephen J. Ansley;Jose L. Badano;Oliver E. Blacque;Josephine Hill.
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
John A. Sayer;John A. Sayer;Edgar A. Otto;John F. O'Toole;Gudrun Nurnberg.
Nature Genetics (2006)
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
Alison J Ross;Helen May-Simera;Erica R Eichers;Masatake Kai.
Nature Genetics (2005)
Genes and molecular pathways underpinning ciliopathies
Jeremy F. Reiter;Michel R. Leroux.
Nature Reviews Molecular Cell Biology (2017)
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
Jun Chul Kim;Jose L Badano;Sonja Sibold;Muneer A Esmail.
Nature Genetics (2004)
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
Oliver E. Blacque;Michael J. Reardon;Chunmei Li;Jonathan McCarthy.
Genes & Development (2004)
Functional coordination of intraflagellar transport motors
Guangshuo Ou;Oliver E. Blacque;Joshua J. Snow;Michel R. Leroux.
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
Jeremy F Reiter;Oliver E Blacque;Michel R Leroux.
EMBO Reports (2012)
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.
Yanli Fan;Muneer A Esmail;Stephen J Ansley;Oliver E Blacque.
Nature Genetics (2004)
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