World's Best Scientists 2026 revealed!
Nico Ghilardi

Nico Ghilardi

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
19145
World Ranking
16441
National Ranking
6802

Overview

Nico Ghilardi is affiliated with Genentech in the United States and contributes extensively to medical and immunological research. Their work spans multiple subfields, including immunology, genetics, rheumatology, pathology and forensic medicine, as well as pulmonary and respiratory medicine.

The scientist specializes in several research topics that focus on the immune system and related diseases. These main topics include:

  • T-cell and B-cell Immunology
  • Systemic Lupus Erythematosus Research
  • IL-33, ST2, and ILC Pathways
  • Whipple's Disease and Interleukins
  • Inflammatory Bowel Disease
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Sarcoidosis and Beryllium Toxicity Research

Ghilardi's publications appear in prominent scientific journals, with frequent contributions to venues such as PLoS ONE, The Journal of Experimental Medicine, Science Translational Medicine, Science Signaling, and the Annual Review of Immunology.

Some of their recent papers include:

  • The role of IL-22 in intestinal health and disease, 2020, The Journal of Experimental Medicine
  • TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis, 2021, Science Translational Medicine
  • The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells, 2020, Science Signaling
  • The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models, 2021, PLoS ONE
  • 30 Years of Biotherapeutics Development-What Have We Learned?, 2020, Annual Review of Immunology

Ghilardi frequently collaborates with other researchers, including Hans D. Brightbill, Jason A. Hackney, Zhiyu Huang, Patrick Caplazi, and Zora Modrušan.

Their research primarily falls under broad fields such as Medicine and Immunology and Microbiology, reflecting a focus on both fundamental and clinical immunology. This body of work covers multiple immunological mechanisms and disease pathogenesis, often addressing complex conditions like autoimmune diseases and fibrotic disorders.

Best Publications

  • Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

    Sudeepta Aggarwal;Nico Ghilardi;Ming-Hong Xie;Frederic J. de Sauvage

  • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

    Yan Zheng;Patricia A Valdez;Dimitry M Danilenko;Yan Hu

  • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

    Marcel Batten;J i Li;Sothy Yi;Noelyn M Kljavin

  • Defective STAT signaling by the leptin receptor in diabetic mice.

    Nico Ghilardi;Sandra Ziegler;Adrian Wiestner;Ruedi Stoffel

  • Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

    Marie Louise Håkansson;Hilary Brown;Nico Ghilardi;Radek C. Skoda

  • Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

    Kyle I. Happel;Patricia J. Dubin;Mingquan Zheng;Nico Ghilardi

  • IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available

    Shabaana A. Khader;John E. Pearl;Kaori Sakamoto;Leigh Gilmartin

  • CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

    Karim Y. Helmy;Kenneth J. Katschke;Nick N. Gorgani;Noelyn M. Kljavin

  • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

    Sophie Lucas;Nico Ghilardi;Ji Li;Frédéric J. de Sauvage

  • Development of Th1-type immune responses requires the type I cytokine receptor TCCR

    Chen Q;Ghilardi N;Wang H;Baker T

  • The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

    Nico Ghilardi;Radek C. Skoda

  • Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

    Shabaana A. Khader;Santiago Partida-Sanchez;Guy Bell;Dawn M. Jelley-Gibbs

  • A mouse knockout library for secreted and transmembrane proteins.

    Tracy Tang;Li Li;Jerry Tang;Yun Li

  • Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

    Melba Muñoz;Markus M. Heimesaat;Kerstin Danker;Daniela Struck

  • The role of IL-22 in intestinal health and disease.

    Mary E. Keir;Tangsheng Yi;Timothy T. Lu;Nico Ghilardi

  • Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

    Heather R. Conti;Alanna C. Peterson;Lucas Brane;Anna R. Huppler

  • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells.

    Marcel Batten;Noelyn M. Kljavin;Ji Li;Michael J. Walter

  • Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

    Nico Ghilardi;Noelyn Kljavin;Qi Chen;Sophie Lucas

  • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

    Marcel Batten;Marcel Batten;Nandhini Ramamoorthi;Noelyn M. Kljavin;Cindy S. Ma;Cindy S. Ma

  • Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages

    Finlay W. McNab;John Ewbank;Ashleigh Howes;Lucia Moreira-Teixeira

Frequent Co-Authors

Zora Modrusan
Zora Modrusan Genentech
Radek C. Skoda
Radek C. Skoda University Hospital of Basel
Mark Ultsch
Mark Ultsch Genentech
Wenjun Ouyang
Wenjun Ouyang Amgen (United States)
Audrey Goddard
Audrey Goddard Gilead Sciences
Wyne P. Lee
Wyne P. Lee Genentech
David Arnott
David Arnott Genentech

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry opens doors to a wide range of online degrees and healthcare career opportunities in the USA. Many students are now turning to online programs to gain essential qualifications while balancing work or family commitments.

Nutrition, radiology, ultrasound technology, and dietetics are closely connected fields that build on a strong foundation in biological sciences. If you're interested in food science and health, consider a cheapest online nutrition degree to get started with an affordable master's program.

For those drawn to medical imaging, an ultrasound tech school or online associate radiology tech programs can provide the training needed to launch a career in diagnostics.

If your passion is clinical nutrition, earning a credential from one of the top dietetics masters programs can prepare you for high-demand roles in hospitals, research labs, or public health.

These online degrees offer flexibility, hands-on learning, and strong career prospects, making them an excellent choice for biology and biochemistry students looking to specialize further.

Best Scientists Citing Nico Ghilardi

Trending Scientists

Recently Published Articles