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Biology and Biochemistry

D-Index
65
Citations
17835
World Ranking
9042
National Ranking
4020

Overview

Marc Yudkoff is affiliated with the Children's Hospital of Philadelphia in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, focusing particularly on metabolic and genetic disorders.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their subfields of study cover clinical biochemistry, molecular biology, rheumatology, pediatrics, perinatology and child health, as well as physiology.

The core topics of their research address metabolism and genetic disorders, mitochondrial function and pathology, folate and B vitamins research, amino acid enzymes and metabolism, diet and metabolism studies, neonatal and fetal brain pathology, and neonatal health and biochemistry.

Frequent publication venues for their work include:

  • Human Genetics
  • Human Mutation
  • Scientific Reports
  • Clinical Liver Disease
  • Neurotherapeutics

Notable recent publications by Marc Yudkoff include:

  • "From genotype to phenotype: Early prediction of disease severity in argininosuccinic aciduria," 2020, Human Mutation
  • "ASL expression in ALDH1A1+ neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype," 2021, Human Genetics
  • "Long-term effects of medical management on growth and weight in individuals with urea cycle disorders," 2020, Scientific Reports
  • "Hepatic Manifestations of Urea Cycle Disorders," 2021, Clinical Liver Disease
  • "Inborn error of metabolism patients after liver transplantation: Outcomes of 35 patients over 27 years in one pediatric quaternary hospital," 2022, American Journal of Medical Genetics Part A

Marc Yudkoff frequently collaborates with several coauthors, including Susan A. Berry, Jessica I. Gold, Rebecca Ganetzky, Matthias R. Baumgartner, and Jirair K. Bedoyan. These collaborations reflect a network across several areas of metabolic and genetic research.

Best Publications

  • Beyond aerobic glycolysis : Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

    Ralph J. DeBerardinis;Anthony Mancuso;Evgueni Daikhin;Ilana Nissim

  • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

    David R. Wise;Ralph J. Deberardinis;Anthony Mancuso;Nabil Sayed

  • Compartmentation of brain glutamate metabolism in neurons and glia.

    Yevgeny Daikhin;Marc Yudkoff

  • A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.

    Steven E. Raper;Marc Yudkoff;Narendra Chirmule;Guang-Ping Gao

  • Factors determining the selectivity of protein tyrosine nitration.

    José M. Souza;Evgueni Daikhin;Marc Yudkoff;C.S. Raman

  • Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.

    Barbara S. Slusher;James J. Vornov;Ajit G. Thomas;Patricia D. Hurn

  • Proteolytic Degradation of Tyrosine Nitrated Proteins

    José M. Souza;Irene Choi;Qiping Chen;Marie Weisse

  • Brain metabolism of branched-chain amino acids

    Marc Yudkoff

  • Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies.

    Maria Erecińska;David Nelson;Yevgeny Daikhin;Yevgeny Daikhin;Marc Yudkoff;Marc Yudkoff

  • Cross-sectional multicenter study of patients with urea cycle disorders in the United States.

    Mendel Tuchman;Brendan Lee;Uta Lichter-Konecki;Marshall L. Summar

  • Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle.

    M Yudkoff;D Nelson;Y Daikhin;M Erecińska

  • A role for bacterial urease in gut dysbiosis and Crohn’s disease

    Josephine Ni;Ting-Chin David Shen;Eric Z. Chen;Kyle Bittinger

  • The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

    Marc Yudkoff;Yevgeny Daikhin;Torun Margareta Melø;Ilana Nissim

  • Brain Amino Acid Requirements and Toxicity: The Example of Leucine

    Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Oksana Horyn

  • Glutathione turnover in cultured astrocytes: Studies with [15N]glutamate

    Marc Yudkoff;David E Pleasure;Lynn Cregar;Zhi Ping Lin

  • A Signaling Role of Glutamine in Insulin Secretion

    Changhong Li;Carol Buettger;Jae Kwagh;Andrea Matter

  • Engineering the gut microbiota to treat hyperammonemia

    Ting-Chin David Shen;Lindsey Albenberg;Kyle Bittinger;Christel Chehoud

  • Regulation of Leucine-stimulated Insulin Secretion and Glutamine Metabolism in Isolated Rat Islets

    Changhong Li;Habiba Najafi;Yevgeny Daikhin;Ilana B. Nissim

  • Ketogenic diet, amino acid metabolism, and seizure control.

    Marc Yudkoff;Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Adam Lazarow

  • Response of brain amino acid metabolism to ketosis

    Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Oksana Horyn

Frequent Co-Authors

Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
Stanton Segal
Stanton Segal University of Pennsylvania
David E Pleasure
David E Pleasure University of California, Davis
Maria Erecińska
Maria Erecińska University of Pennsylvania
Charles A. Stanley
Charles A. Stanley Children's Hospital of Philadelphia
Michael B. Robinson
Michael B. Robinson Children's Hospital of Philadelphia
Gary D. Wu
Gary D. Wu University of Pennsylvania
Harry Ischiropoulos
Harry Ischiropoulos Children's Hospital of Philadelphia
Frederic D. Bushman
Frederic D. Bushman University of Pennsylvania
Michael J. Bennett
Michael J. Bennett University Hospital Southampton NHS Foundation Trust

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