World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
83
Citations
19176
World Ranking
15812
National Ranking
7957

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David E Pleasure is affiliated with the University of California, Davis in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, producing a significant body of work across related subfields. The scientist's contributions have been published extensively, with frequent appearances in journals such as Annals of Neurology and Glia.

The primary fields of study associated with David E Pleasure include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these main fields, their work focuses on specific subfields, including:

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Pulmonary and Respiratory Medicine
  • Neurology
  • Pathology and Forensic Medicine

The scientist's main topics of research encompass:

  • Advanced MRI Techniques and Applications
  • Mitochondrial Function and Pathology
  • RNA regulation and disease
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Multiple Sclerosis Research Studies
  • T-cell and B-cell Immunology
  • PARP inhibition in cancer therapy

David E Pleasure's recent publications reflect this diverse research landscape. Notable papers include:

  • "Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice," 2020, Annals of Neurology
  • "Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination," 2021, Neurobiology of Disease
  • "Therapeutic Potentials of Poly (ADP-Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting," 2021, Advanced Science
  • "CSF1R antagonism results in increased supraspinal infiltration in EAE," 2024, Journal of Neuroinflammation
  • "Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice," 2021, Annals of Neurology

Frequent coauthors in their research include:

  • Yan Wang
  • Fuzheng Guo
  • Vanessa L. Hull
  • Travis Burns
  • Jennifer McDonough

Academic publications are predominately found in the following venues:

  • Annals of Neurology
  • Glia
  • Neurobiology of Disease
  • Advanced Science
  • Journal of Neuroinflammation

David E Pleasure has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS), an award received in 2005.

Best Publications

  • Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome.

    Herbert Schaumburg;Jerry Kaplan;Anthony Windebank;Nicholas Vick

  • Arthrogryposis: A Review and Update

    Michael Bamshad;Ann E. Van Heest;David E Pleasure

  • Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates

    Andrew V. Albright;Joseph T. C. Shieh;Takayuki Itoh;Benhur Lee

  • Prospects for Minocycline Neuroprotection

    Jennifer M. Plane;Yan Shen;David E. Pleasure;Wenbin Deng

  • Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

    John C. Reed;Lynn Meister;Shigeki Tanaka;Michael Cuddy

  • Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus

    Sundari Chetty;Aaron R Friedman;Kereshmeh Taravosh-Lahn;Elizabeth D Kirby

  • Progress in periventricular leukomalacia

    Wenbin Deng;Jeanette Pleasure;David E Pleasure

  • Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

    Chen Chen;Peng Jiang;Haipeng Xue;Suzanne E Peterson

  • Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

    Donald P. Younkin;Cha Min Tang;Mattie Hardy;Usha R. Reddy

  • Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

    Fuzheng Guo;Yoshiko Maeda;Joyce Ma;Jie Xu

  • A TSPO ligand is protective in a mouse model of multiple sclerosis

    Daniel J. Daugherty;Vimal Selvaraj;Vimal Selvaraj;Olga V. Chechneva;Xiao Bo Liu

  • Glutathione turnover in cultured astrocytes: Studies with [15N]glutamate

    Marc Yudkoff;David E Pleasure;Lynn Cregar;Zhi Ping Lin

  • AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes.

    Takayuki Itoh;Jacqueline Beesley;Aki Itoh;Akiva S. Cohen

  • Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis

    Athena M. Soulika;Eunyoung Lee;Erica McCauley;Laird Miers

  • Antibodies to Oligodendroglia in Patients with Multiple Sclerosis

    O. Abramsky;R. P. Lisak;D. H. Silberberg;David E Pleasure

  • Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage.

    Judith B. Grinspan;Eric Edell;David F. Carpio;Jacqueline S. Beesley

  • Pathophysiology of oligodendroglial excitotoxicity.

    Akira Yoshioka;Brian Bacskai;David E Pleasure

  • Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion

    Lanying Song;Lanying Song;Yunhong Li;Kai Wang;Ya-Zhou Wang;Ya-Zhou Wang

  • Enrichment of Schwann cell cultures from neonatal rat sciatic nerve by differential adhesion

    B. Q. Kreider;B. Q. Kreider;A. Messing;A. Messing;H. Doan;H. Doan;S. U. Kim;S. U. Kim

  • Schwann cell responses to cyclic AMP: Proliferation, change in shape, and appearance of surface galactocerebroside

    Gen Sobue;Sandra Shuman;David E Pleasure

Frequent Co-Authors

Robert P. Lisak
Robert P. Lisak Wayne State University
Marc Yudkoff
Marc Yudkoff Children's Hospital of Philadelphia
Gen Sobue
Gen Sobue Aichi Medical University
Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
Alonzo H. Ross
Alonzo H. Ross University of Massachusetts Chan Medical School
Elio Scarpini
Elio Scarpini University of Milan
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
John Kamholz
John Kamholz University of Iowa Hospitals and Clinics
Ying Liu
Ying Liu The University of Texas Health Science Center at Houston
Samuel J. Pleasure
Samuel J. Pleasure University of California, San Francisco

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