World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
43554
World Ranking
763
National Ranking
480

Medicine

D-Index
115
Citations
43298
World Ranking
4597
National Ranking
2497

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Mark A. Magnuson is affiliated with Vanderbilt University in the United States. Their research spans multiple fields, mainly focusing on biochemistry, genetics, molecular biology, and medicine. The scientist has contributed extensively to surgery, molecular biology, genetics, endocrinology, diabetes, metabolism, and cell biology through over fifty publications.

The core areas of research revolve around pancreatic function and diabetes, which are featured in more than fifty publications. Other prominent topics include diabetes and associated disorders, metabolism related to diabetes and cancer, genetics and neurodevelopmental disorders, genomics and chromatin dynamics, single-cell and spatial transcriptomics, and endoplasmic reticulum stress and disease.

Frequent coauthors include Anna B. Osipovich with 21 joint publications, Jean-Philippe Cartailler with 14, Linh T. Trinh with 9, Shristi Shrestha with 8, and Leesa Sampson with 8 publications.

Magnuson's research output is commonly published in several venues. The most frequent publication venues are Diabetes and bioRxiv (Cold Spring Harbor Laboratory), each with seven publications, followed by Development with two, and the journals iScience and eLife with two each.

Several recent papers illustrate the diverse scope of their research:

  • Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones, 2020, Nature Genetics
  • Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy, 2020, The American Journal of Human Genetics
  • Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation, 2020, Diabetes
  • A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development, 2021, Development
  • Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells, 2020, Diabetes

Magnuson has been recognized by the scientific community through election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013. They are also a member of the Association of American Physicians.

Best Publications

  • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

    Martin F. Offield;Tom L. Jetton;Patricia A. Labosky;Michael Ray

  • Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

    M.Dodson Michael;Rohit N. Kulkarni;Catherine Postic;Steven F. Previs

  • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

    C. Postic;M. Shiota;K. D. Niswender;T. L. Jetton

  • Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

    R N Kulkarni;J C Brüning;J N Winnay;C Postic

  • Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

    You Fei Guan;Chuanming Hao;Dae Ryong Cha;Reena Rao

  • Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

    Joseph Grimsby;Ramakanth Sarabu;Wendy L. Corbett;Nancy-Ellen Haynes

  • Identification of Protor as a novel Rictor-binding component of mTOR complex-2

    Laura R. Pearce;Xu Huang;Jérôme Boudeau;Rafał Pawłowski

  • Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

    Julie R. Jones;Cordelia Barrick;Kyoung-Ah Kim;Jill Lindner

  • Neonatal diabetes mellitus due to complete glucokinase deficiency.

    Pål R. Njølstad;Oddmund Søvik;Antonio Cuesta-Muñoz;Lise Bjørkhaug

  • Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

    Keunwook Lee;Prathyusha Gudapati;Srdjan Dragovic;Charles Spencer

  • Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

    Renaud Dentin;Jean-Paul Pégorier;Fadila Benhamed;Fabienne Foufelle

  • Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

    Bangyan Stiles;Ying Wang;Andreas Stahl;Sara Bassilian

  • Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

    José P. Silva;Martin Köhler;Caroline Graff;Anders Oldfors

  • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

    Chiyo Shiota;Jeong-Taek Woo;Jill Lindner;Kathy D. Shelton

  • mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

    David A. Guertin;Deanna M. Stevens;Maki Saitoh;Stephanie Kinkel

  • SALT-SENSITIVE HYPERTENSION AND REDUCED FERTILITY IN MICE LACKING THE PROSTAGLANDIN EP2 RECEPTOR

    Christopher R.J. Kennedy;Yahua Zhang;Suzanne Brandon;Youfei Guan

  • beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

    R N Kulkarni;M Holzenberger;D Q Shih;U Ozcan

  • Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.

    Susan O. Castillo;Judit S. Baffi;Miklós Palkovits;David S. Goldstein

  • Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

    F M Matschinsky;B Glaser;M A Magnuson

  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

    Takao Sakai;Kamin J. Johnson;Kamin J. Johnson;Kamin J. Johnson;Michihiro Murozono;Michihiro Murozono;Keiko Sakai

Frequent Co-Authors

Christopher V.E. Wright
Christopher V.E. Wright Vanderbilt University
Catherine Postic
Catherine Postic Institut Cochin
David W. Piston
David W. Piston Washington University in St. Louis
Franz M. Matschinsky
Franz M. Matschinsky University of Pennsylvania
Daryl K. Granner
Daryl K. Granner Vanderbilt University
Roland Stein
Roland Stein Vanderbilt University
Christian J. Stoeckert
Christian J. Stoeckert University of Pennsylvania
A. Dean Sherry
A. Dean Sherry The University of Texas Southwestern Medical Center
Raymond J. MacDonald
Raymond J. MacDonald The University of Texas Southwestern Medical Center
Alvin C. Powers
Alvin C. Powers Vanderbilt University Medical Center

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