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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
15018
World Ranking
6777
National Ranking
3137

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Richard M. Breyer is affiliated with Vanderbilt University Medical Center in the United States. Their research spans multiple fields within medicine and biochemistry, genetics, and molecular biology, with a concentration in pharmacology, molecular biology, surgery, immunology, and physiology.

Their scientific work covers several main topics including inflammatory mediators and NSAID effects, gut microbiota and health, Helicobacter pylori-related gastroenterology studies, pancreatic function and diabetes, adenosine and purinergic signaling, IL-33, ST2, and ILC pathways, and eosinophilic esophagitis.

Frequently, Breyer collaborates with the following coauthors:

  • Chengcan Yao
  • Marie Goepp
  • You Zhou
  • Jürgen Schwarze
  • Shuh Narumiya

Their recent published papers illustrate a focus on inflammatory and vascular biology as well as intestinal and pulmonary health. Selected works include:

  • Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche, 2020, Nature
  • Prostaglandin E 2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells, 2021, Science Advances
  • Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling, 2020, American Journal of Respiratory and Critical Care Medicine
  • DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells, 2020, Circulation
  • Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation, 2020, Arteriosclerosis Thrombosis and Vascular Biology

Breyer has published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature, Science Advances, American Journal of Respiratory and Critical Care Medicine, and Circulation.

In recognition of their contributions to science, Richard M. Breyer was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2014.

Best Publications

  • Prostanoid receptors: subtypes and signaling.

    Richard M Breyer;Carey K Bagdassarian;Scott A Myers;Matthew D Breyer

  • Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation

    Aaron N. Hata;Richard M. Breyer

  • SALT-SENSITIVE HYPERTENSION AND REDUCED FERTILITY IN MICE LACKING THE PROSTAGLANDIN EP2 RECEPTOR

    Christopher R.J. Kennedy;Yahua Zhang;Suzanne Brandon;Youfei Guan

  • Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

    Louise D Mccullough;Liejun Wu;Norman Haughey;Xibin Liang

  • Prostaglandin E receptors and the kidney

    Matthew D. Breyer;Richard M. Breyer

  • Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.

    David J. Figueroa;Richard M. Breyer;Stephanie K. Defoe;Stacia Kargman

  • Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.

    Zhonghua Qi;Chuan-Ming Hao;Robert I. Langenbach;Richard M. Breyer

  • Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor

    Li Yang;Noboru Yamagata;Rajwardhan Yadav;Suzanne Brandon

  • G protein-coupled prostanoid receptors and the kidney.

    Matthew D Breyer;Richard M Breyer

  • Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

    Xibin Liang;Qian Wang;Tracey Hand;Liejun Wu

  • Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.

    You-Fei Guan;Ya-Hua Zhang;Richard M. Breyer;Linda Davis

  • Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.

    Manolis Roulis;Aimilios Kaklamanos;Marina Schernthanner;Piotr Bielecki

  • Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro.

    Xiaodong Li;Yosuke Okada;Carol C. Pilbeam;Joseph A. Lorenzo

  • Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis

    Rodger Duffin;Richard A. O’Connor;Siobhan Crittenden;Thorsten Forster

  • Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2

    Jonathan Hoggatt;Khalid S. Mohammad;Pratibha Singh;Amber F. Hoggatt;Amber F. Hoggatt

  • Functional and molecular aspects of renal prostaglandin receptors.

    Matthew D. Breyer;Harry R. Jacobson;Richard M. Breyer

  • Diversification of Cyclooxygenase-2-Derived Prostaglandins in Ovulation and Implantation

    Hiromichi Matsumoto;Wen-ge Ma;Whitney Smalley;James Trzaskos

  • Decreased Expression of Tumor Necrosis Factor-α-Stimulated Gene 6 in Cumulus Cells of the Cyclooxygenase-2 and EP2 Null Mice

    Scott A. Ochsner;Darryl L. Russell;Anthony J. Day;Richard M. Breyer

  • Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation

    Ambra Pozzi;Xuexian Yan;Ines Macias-Perez;Shouzuo Wei

  • Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.

    B Bertin;M Freissmuth;R M Breyer;W Schütz

Frequent Co-Authors

Matthew D. Breyer
Matthew D. Breyer Eli Lilly (United States)
Thomas J. Montine
Thomas J. Montine Stanford University
Katrin Andreasson
Katrin Andreasson Stanford University
Shuh Narumiya
Shuh Narumiya Kyoto University
Michael Lazarus
Michael Lazarus University of Tsukuba
Roy Zent
Roy Zent Vanderbilt University Medical Center
Ying Yu
Ying Yu Central China Normal University
Charles R. Sanders
Charles R. Sanders Vanderbilt University
Colin D. Funk
Colin D. Funk Queen's University
C. Dirk Keene
C. Dirk Keene University of Washington

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