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Biology and Biochemistry

D-Index
74
Citations
27683
World Ranking
5473
National Ranking
2598

Overview

Lionel Feigenbaum is affiliated with Science Applications International Corporation in the United States. Their research primarily focuses on immunology and microbiology, with notable work in the subfields of immunology and oncology.

Feigenbaum's work encompasses several main topics including:

  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • T-cell and B-cell Immunology

Their recent publications include the paper titled "NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice", published in 2020 in Cellular Immunology. This paper addresses aspects of immune cell function related to lymphoma development.

Frequent coauthors in Feigenbaum's research include:

  • Sigrid Dubois
  • Thomas A. Waldmann
  • Jürgen R. Müller

Their work has appeared in the journal Cellular Immunology, reflecting the scientific venues where they have contributed publications.

Feigenbaum's research integrates elements of immunology and oncology, with an emphasis on the interaction of immune cells and therapeutic approaches involving T-cells, such as CAR-T cell therapy.

Best Publications

  • Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

    Willem W. Overwijk;Marc R. Theoret;Steven E. Finkelstein;Deborah R. Surman

  • Tumor-specific Th17-polarized cells eradicate large established melanoma

    Pawel Muranski;Andrea Boni;Paul A. Antony;Lydie Cassard

  • Life without white fat: a transgenic mouse

    Jaideep Moitra;Mark M. Mason;Michelle Olive;Dmitry Krylov

  • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

    Xuguang Tai;Michelle Cowan;Lionel Feigenbaum;Alfred Singer

  • Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation

    Jonathan A. Deane;Prapaporn Pisitkun;Rebecca S. Barrett;Lionel Feigenbaum

  • Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

    Pawel Muranski;Zachary A. Borman;Sid P. Kerkar;Christopher A. Klebanoff

  • Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

    Jae Jin Chae;Young-Hun Cho;Geun-Shik Lee;Jun Cheng

  • Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.

    Howard E. Gendelman;William Phelps;Lionel Feigenbaum;Jeffrey M. Ostrove

  • Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.

    Diane Palmieri;Julie L. Bronder;Jeanne M. Herring;Toshiyuki Yoneda

  • The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses.

    Jinfang Zhu;Dragana Jankovic;Andrew J. Oler;Gang Wei

  • NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

    Seth L. Masters;Motti Gerlic;Motti Gerlic;Donald Metcalf;Donald Metcalf;Simon Preston;Simon Preston

  • The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.

    Guangping Sun;Xiaolong Liu;Peter Mercado;S Rhiannon Jenkinson

  • Interferon-γ links ultraviolet radiation to melanomagenesis in mice

    M. Raza Zaidi;Sean Davis;Frances P. Noonan;Cari Graff-Cherry

  • Regulation of AID expression in the immune response

    Elizabeth E. Crouch;Zhiyu Li;Makiko Takizawa;Stefan Fichtner-Feigl

  • Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance

    Fang Yu;Suveena Sharma;Julie Edwards;Lionel Feigenbaum

  • Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

    Xuguang Tai;François Van Laethem;Leonid Pobezinsky;Terry Guinter

  • B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity.

    Jason Qian;Qiao Wang;Marei Dose;Nathanael Pruett

  • Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

    Simone Difilippantonio;Arkady Celeste;Oscar Fernandez-Capetillo;Hua-Tang Chen

  • In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.

    Ogyi Park;Hua Wang;Honglei Weng;Lionel Feigenbaum

  • Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor α

    Connie Cheung;Taro E. Akiyama;Jerrold M. Ward;Christopher J. Nicol

Frequent Co-Authors

Alfred Singer
Alfred Singer National Institutes of Health
André Nussenzweig
André Nussenzweig National Institutes of Health
Susan O. Sharrow
Susan O. Sharrow National Institutes of Health
Howard A. Young
Howard A. Young National Institutes of Health
Lino Tessarollo
Lino Tessarollo National Institutes of Health
Rafael Casellas
Rafael Casellas The University of Texas MD Anderson Cancer Center
Bradley A. Carlson
Bradley A. Carlson National Institutes of Health
Dolph L. Hatfield
Dolph L. Hatfield National Institutes of Health
Michael J. Kruhlak
Michael J. Kruhlak National Institutes of Health
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital

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