What is he best known for?
The fields of study he is best known for:
- Gene
- Immune system
- T cell
Alfred Singer mostly deals with Cell biology, CD8, Immunology, T-cell receptor and Signal transduction.
His studies in Cell biology integrate themes in fields like Cell, Cell membrane, Thymocyte, CD28 and Major histocompatibility complex.
Alfred Singer interconnects Cytotoxic T cell, Lineage and Cell fate determination in the investigation of issues within CD8.
His research investigates the link between Immunology and topics such as Phenotype that cross with problems in Bone marrow chimeras, Host cell surface and Immune system.
The concepts of his T-cell receptor study are interwoven with issues in Tyrosine kinase, Epithelium, Intracellular and Antigen.
His studies deal with areas such as Receptor, MHC class I, Flow cytometry and Cytokine as well as Signal transduction.
His most cited work include:
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. (525 citations)
- Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines: A Novel Mechanism for Maximizing IL-7-Dependent T Cell Survival (420 citations)
- Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. (339 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Cell biology, Immunology, CD8, T-cell receptor and T cell.
His Cell biology study combines topics from a wide range of disciplines, such as CD28, Cell, Cancer research and Transcription factor.
Immunology is frequently linked to Transplantation in his study.
His CD8 research is multidisciplinary, relying on both Lineage and Cellular differentiation.
His research in T-cell receptor intersects with topics in Thymocyte, Transgene, Receptor, Signal transduction and CD3.
The various areas that he examines in his T cell study include B cell, Molecular biology, Cytotoxic T cell, Transcription and In vivo.
He most often published in these fields:
- Cell biology (42.42%)
- Immunology (39.39%)
- CD8 (37.66%)
What were the highlights of his more recent work (between 2010-2020)?
- T-cell receptor (35.50%)
- Cell biology (42.42%)
- CD8 (37.66%)
In recent papers he was focusing on the following fields of study:
Alfred Singer mainly focuses on T-cell receptor, Cell biology, CD8, Major histocompatibility complex and Transcription factor.
His T-cell receptor study is concerned with the field of Immunology as a whole.
His Immunology study incorporates themes from Apoptosis, microRNA and Cellular differentiation.
His studies in Cell biology integrate themes in fields like Chromatin, Receptor, Regulation of gene expression and BRD4.
His CD8 research is multidisciplinary, incorporating perspectives in Cytotoxic T cell, Transcription, Molecular biology and T cell.
His research in the fields of MHC restriction overlaps with other disciplines such as CD155, Selection and Repertoire.
Between 2010 and 2020, his most popular works were:
- Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells. (160 citations)
- Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals (150 citations)
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection (109 citations)
In his most recent research, the most cited papers focused on:
Alfred Singer spends much of his time researching T-cell receptor, Cell biology, Signal transduction, Immunology and Cytotoxic T cell.
Alfred Singer interconnects Genetic variation and Major histocompatibility complex, Antigen in the investigation of issues within T-cell receptor.
His study on Immunology is mostly dedicated to connecting different topics, such as Cellular differentiation.
His research on Cytotoxic T cell frequently links to adjacent areas such as Molecular biology.
His MHC class I study results in a more complete grasp of CD8.
CD8 is closely attributed to Receptor in his work.
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