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Immunology

D-Index
84
Citations
26916
World Ranking
1366
National Ranking
700

Overview

Alfred Singer is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the field of Immunology and Microbiology, with a specialized emphasis on Immunology. This research spans several interconnected topics, including T-cell and B-cell Immunology, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, CAR-T cell therapy research, and Reproductive System and Pregnancy.

The scientist has contributed to numerous publications across several notable venues, with repeated appearances in Nature Immunology and Frontiers in Immunology. Other publication venues include Science, The Journal of Immunology, and Clinical and Translational Medicine.

Recent papers authored or coauthored by Alfred Singer include the following:

  • How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion, 2023, Nature Immunology
  • Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus, 2022, Nature Immunology
  • CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus, 2023, Science
  • Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155, 2020, The Journal of Immunology
  • Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus, 2020, Frontiers in Immunology

Frequent coauthors collaborating with Alfred Singer include:

  • Xuguang Tai
  • Abhisek Bhattacharya
  • Amala Alag
  • Terry I. Guinter
  • Jinghua Lu

The scientist's work covers critical aspects of the immune system, particularly focusing on T-cell development, tolerance, and lineage fate decisions within the thymus. Their studies address the molecular mechanisms by which autoreactive thymocytes differentiate into various T cell subsets, as well as the role of MHC-independent T cell receptors in antigen recognition.

Best Publications

  • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

    Shimon Sakaguchi;Noriko Sakaguchi;Masanao Asano;Misako Itoh

  • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

    Xuguang Tai;Michelle Cowan;Lionel Feigenbaum;Alfred Singer

  • Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

    Alfred Singer;Stanley Adoro;Jung-Hyun Park

  • Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.

    Jung-Hyun Park;Qing Yu;Batu Erman;Jacob S. Appelbaum

  • Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.

    and A S Rosenberg;A Singer

  • Crosstalk in the mouse thymus.

    Willem van Ewijk;Elisabeth W. Shores;Alfred Singer

  • Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

    J A Punt;B A Osborne;Y Takahama;S O Sharrow

  • Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells

    Enrico Brugnera;Avinash Bhandoola;Ricardo Cibotti;Qing Yu

  • Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

    Xuguang Tai;François Van Laethem;Leonid Pobezinsky;Terry Guinter

  • Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

    Harumi Suzuki;Jennifer A. Punt;Lawrence G. Granger;Alfred Singer

  • T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

    Paul E. Love;Elizabeth W. Shores;Mark D. Johnson;Michel L. Tremblay

  • Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment.

    Elizabeth W. Shores;Willem Van Ewijk;Alfred Singer

  • Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

    Xuguang Tai;Batu Erman;Amala Alag;Jie Mu

  • Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

    A S Rosenberg;T Mizuochi;S O Sharrow;A Singer

  • Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

    François Van Laethem;Sophia D. Sarafova;Jung-Hyun Park;Xuguang Tai

  • New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

    Alfred Singer

  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

    Jung-Hyun Park;Stanley Adoro;Stanley Adoro;Philip J Lucas;Sophia D Sarafova;Sophia D Sarafova

  • Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

    D L Wiest;L Yuan;J Jefferson;P Benveniste

  • Self recognition in allogeneic radiation bone marrow chimeras. A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells.

    Alfred Singer;Karen S. Hathcock;Richard J. Hodes

  • Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

    Leonid A Pobezinsky;Georgi S Angelov;Xuguang Tai;Susanna Jeurling

  • Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

    Zvi Grossman;Alfred Singer

Frequent Co-Authors

Susan O. Sharrow
Susan O. Sharrow National Institutes of Health
Richard J. Hodes
Richard J. Hodes National Institutes of Health
Lionel Feigenbaum
Lionel Feigenbaum Science Applications International Corporation (United States)
Avinash Bhandoola
Avinash Bhandoola National Institutes of Health
Yousuke Takahama
Yousuke Takahama National Institutes of Health
Toshinori Nakayama
Toshinori Nakayama Chiba University
Dinah S. Singer
Dinah S. Singer National Institutes of Health
Paul E. Love
Paul E. Love National Institutes of Health
Peter D. Sun
Peter D. Sun National Institutes of Health

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