Alfred Singer mostly deals with Cell biology, CD8, Immunology, T-cell receptor and Signal transduction. His studies in Cell biology integrate themes in fields like Cell, Cell membrane, Thymocyte, CD28 and Major histocompatibility complex. Alfred Singer interconnects Cytotoxic T cell, Lineage and Cell fate determination in the investigation of issues within CD8.
His research investigates the link between Immunology and topics such as Phenotype that cross with problems in Bone marrow chimeras, Host cell surface and Immune system. The concepts of his T-cell receptor study are interwoven with issues in Tyrosine kinase, Epithelium, Intracellular and Antigen. His studies deal with areas such as Receptor, MHC class I, Flow cytometry and Cytokine as well as Signal transduction.
His main research concerns Cell biology, Immunology, CD8, T-cell receptor and T cell. His Cell biology study combines topics from a wide range of disciplines, such as CD28, Cell, Cancer research and Transcription factor. Immunology is frequently linked to Transplantation in his study.
His CD8 research is multidisciplinary, relying on both Lineage and Cellular differentiation. His research in T-cell receptor intersects with topics in Thymocyte, Transgene, Receptor, Signal transduction and CD3. The various areas that he examines in his T cell study include B cell, Molecular biology, Cytotoxic T cell, Transcription and In vivo.
Alfred Singer mainly focuses on T-cell receptor, Cell biology, CD8, Major histocompatibility complex and Transcription factor. His T-cell receptor study is concerned with the field of Immunology as a whole. His Immunology study incorporates themes from Apoptosis, microRNA and Cellular differentiation.
His studies in Cell biology integrate themes in fields like Chromatin, Receptor, Regulation of gene expression and BRD4. His CD8 research is multidisciplinary, incorporating perspectives in Cytotoxic T cell, Transcription, Molecular biology and T cell. His research in the fields of MHC restriction overlaps with other disciplines such as CD155, Selection and Repertoire.
Alfred Singer spends much of his time researching T-cell receptor, Cell biology, Signal transduction, Immunology and Cytotoxic T cell. Alfred Singer interconnects Genetic variation and Major histocompatibility complex, Antigen in the investigation of issues within T-cell receptor. His study on Immunology is mostly dedicated to connecting different topics, such as Cellular differentiation.
His research on Cytotoxic T cell frequently links to adjacent areas such as Molecular biology. His MHC class I study results in a more complete grasp of CD8. CD8 is closely attributed to Receptor in his work.
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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Xuguang Tai;Michelle Cowan;Lionel Feigenbaum;Alfred Singer.
Nature Immunology (2005)
Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines: A Novel Mechanism for Maximizing IL-7-Dependent T Cell Survival
Jung-Hyun Park;Qing Yu;Batu Erman;Jacob S. Appelbaum.
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.
Alfred Singer;Stanley Adoro;Jung-Hyun Park.
Nature Reviews Immunology (2008)
Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
and A S Rosenberg;A Singer.
Annual Review of Immunology (1992)
Crosstalk in the mouse thymus.
Willem van Ewijk;Elisabeth W. Shores;Alfred Singer.
Immunology Today (1994)
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
J A Punt;B A Osborne;Y Takahama;S O Sharrow.
Journal of Experimental Medicine (1994)
Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells
Enrico Brugnera;Avinash Bhandoola;Ricardo Cibotti;Qing Yu.
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection
Harumi Suzuki;Jennifer A. Punt;Lawrence G. Granger;Alfred Singer.
Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.
A S Rosenberg;T Mizuochi;S O Sharrow;A Singer.
Journal of Experimental Medicine (1987)
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex
Paul E. Love;Elizabeth W. Shores;Mark D. Johnson;Michel L. Tremblay.
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