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Molecular Biology

D-Index
63
Citations
15451
World Ranking
1802
National Ranking
902

Overview

Jeffrey D. Parvin is affiliated with The Ohio State University in the United States. Their research focuses on key areas within biochemistry, genetics, and molecular biology, contributing extensively to topics related to DNA repair mechanisms, CRISPR and genetic engineering, as well as the role of BRCA gene mutations in cancer.

The scientist has published a significant body of work spanning molecular biology, genetics, oncology, immunology, and epidemiology. Their studies often explore cancer-related genetic mechanisms with a particular emphasis on DNA repair and PARP inhibition in cancer therapy.

Among their recent papers are:

  • Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells, 2021, PLoS ONE
  • The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays, 2022, The American Journal of Human Genetics
  • DNA repair function scores for 2172 variants in the BRCA1 amino-terminus, 2023, PLoS Genetics
  • Multiplexed assay of variant effect reveals residues of functional importance in the BRCA1 coiled-coil and serine cluster domains, 2023, PLoS ONE
  • Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors who have collaborated with Jeffrey D. Parvin include:

  • Gregory Nagy
  • Tapahsama Banerjee
  • S. Dhar
  • Aleksandra I. Adamovich
  • Mariame Diabate

The primary venues where their work has been published encompass:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • The American Journal of Human Genetics
  • PLoS Genetics
  • Cancer Research

Main fields of study in Jeffrey D. Parvin's research portfolio include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields covered are:

  • Molecular Biology
  • Genetics
  • Oncology
  • Immunology
  • Epidemiology

The central topics of their research involve:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • BRCA gene mutations in cancer
  • PARP inhibition in cancer therapy
  • CAR-T cell therapy research
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction

Best Publications

  • Network modeling links breast cancer susceptibility and centrosome dysfunction.

    Miguel Angel Pujana;Jing Dong J Han;Lea M. Starita;Kristen N. Stevens

  • Amplification, expression, and packaging of a foreign gene by influenza virus

    Willem Luytjes;Mark Krystal;Masayoshi Enami;Jeffrey D. Parvin

  • RNA Helicase A Mediates Association of CBP with RNA Polymerase II

    Toshihiro Nakajima;Chiharu Uchida;Stephen F. Anderson;Chee-Gun Lee

  • BRCA1 is a component of the RNA polymerase II holoenzyme

    Ralph Scully;Stephen F. Anderson;David M. Chao;Wanjiang Wei

  • α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

    Eirene Kontopoulos;Jeffrey D. Parvin;Mel B. Feany

  • BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.

    Stephen F. Anderson;Brian P. Schlegel;Toshihiro Nakajima;Eric S. Wolpin

  • DNA topology and a minimal set of basal factors for transcription by RNA polymerase II.

    Jeffrey D. Parvin;Phillip A. Sharp

  • Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.

    J D Parvin;A Moscona;W T Pan;J M Leider

  • Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle

    Ming-Ta Hsu;Jeffrey D. Parvin;Suresh Gupta;Mark Krystal

  • BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

    Lea M. Starita;Yuka Machida;Satish Sankaran;Joshua E. Elias

  • Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.

    Partha Saha;Junjie Chen;Kelly C. Thome;Stephanie J. Lawlis

  • Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene

    Deborah A. Buonagurio;Susumu Nakada;Jeffrey D. Parvin;Mark Krystal

  • Patterns and functional implications of rare germline variants across 12 cancer types

    Charles Lu;Mingchao Xie;Michael C. Wendl;Jiayin Wang;Jiayin Wang

  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

    Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  • Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

    Lea M. Starita;David L. Young;Muhtadi Islam;Jacob O. Kitzman

  • Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.

    T Nakajima;C Uchida;S F Anderson;J D Parvin

  • The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.

    Lea M Starita;Jeffrey D Parvin

  • Factors associated with the mammalian RNA polymerase II holoenzyme.

    Andrew S. Neish;Stephen F. Anderson;Brian P. Schlegel;Wanjiang Wei

  • Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor

    Jeffrey D. Parvin;Jeffrey D. Parvin;Richard J. McCormick;Phillip A. Sharp;David E. Fisher

  • Promoter analysis of influenza virus RNA polymerase.

    J D Parvin;P Palese;A Honda;A Ishihama

Frequent Co-Authors

Peter Palese
Peter Palese Icahn School of Medicine at Mount Sinai
Mark Krystal
Mark Krystal ViiV Healthcare (United Kingdom)
Stephen Anderson
Stephen Anderson Rutgers, The State University of New Jersey
Tim H M Huang
Tim H M Huang The University of Texas Health Science Center at San Antonio
Chikashi Ishioka
Chikashi Ishioka Tohoku University
Anindya Dutta
Anindya Dutta University of Alabama at Birmingham
Ümit V. Çatalyürek
Ümit V. Çatalyürek Georgia Institute of Technology
Stanley Fields
Stanley Fields University of Washington
Jay Shendure
Jay Shendure University of Washington

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