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Darío Acuña-Castroviejo

Darío Acuña-Castroviejo

D-Index & Metrics

Medicine

D-Index
84
Citations
24566
World Ranking
15159
National Ranking
215

Overview

Darío Acuña-Castroviejo is affiliated with the University of Granada in Spain and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work spans several subfields, including endocrine and autonomic systems, molecular biology, physiology, cell biology, and cancer research.

The primary research topics covered by Darío Acuña-Castroviejo include circadian rhythm and melatonin, inflammasome and immune disorders, epigenetics and DNA methylation, muscle metabolism and nutrition, mitochondrial function and pathology, genetics, aging and longevity in model organisms, and microRNA in disease regulation.

Selected recent papers authored or coauthored by Darío Acuña-Castroviejo include:

  • Clinical trial to test the efficacy of melatonin in COVID-19, 2020, Journal of Pineal Research
  • The NLRP3 inflammasome: contributions to inflammation-related diseases, 2023, Cellular & Molecular Biology Letters
  • Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport, 2022, Journal of Pineal Research
  • Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging, 2020, Antioxidants
  • Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology

Darío Acuña-Castroviejo has collaborated frequently with several coauthors, including:

  • Germaine Escames
  • José Fernández-Martínez
  • Paula Aranda-Martínez
  • Iryna Rusanova
  • Laura Martínez-Ruiz

Their work has been published predominantly in several venues, with multiple publications appearing in:

  • Antioxidants
  • International Journal of Molecular Sciences
  • Preprints.org
  • Journal of Pineal Research
  • Biomedicines

Best Publications

  • Extrapineal melatonin: sources, regulation, and potential functions.

    Darío Acuña-Castroviejo;Germaine Escames;Carmen Venegas;María E. Díaz-Casado

  • Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

    Carmen Venegas;José A. García;Germaine Escames;Francisco Ortiz

  • Melatonin mitigates mitochondrial malfunction

    Josefa León;Darío Acuña-Castroviejo;Germane Escames;Dyn Xian Tan

  • Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system.

    Russel J. Reiter;Dario Acuña-Castroviejo;Dun Xian Tan;Susanne Burkhardt

  • Melatonin, mitochondria, and cellular bioenergetics.

    Darío Acuña-Castroviejo;Miguel Martín;Manuel Macías;Germaine Escames

  • Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress.

    Miguel Martín;Manuel Macías;Germaine Escames;Josefa León

  • Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

    Russel J. Reiter;Sergio A. Rosales-Corral;Dun Xian Tan;Dario Acuna-Castroviejo

  • Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

    M. Martín;M. Macías;G. Escames;Russel J Reiter

  • Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats

    Elena Crespo;Manuel Macías;David Pozo;Germaine Escames

  • Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin.

    Sergio A. Rosales-Corral;Dario Acuña-Castroviejo;Ana Coto-Montes;Jose A. Boga

  • Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria.

    Miguel Martı́n;Manuel Macı́as;Josefa León;Germaine Escames

  • Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

    Russell J. Reiter;Juan M. Guerrero;Joaquin J. Garcia;Dario Acuña-Castroviejo

  • Melatonin is protective against MPTP-induced striatal and hippocampal lesions.

    Dario Acuña-Castroviejo;Ana Coto-Montes;M.Gaia Monti;Genaro G. Ortiz

  • Melatonin reduces nitric oxide synthase activity in rat hypothalamus

    Ilham Bettahi;David Pozo;Carmen Osuna;Russel J. Reiter

  • Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks.

    Marta I. Pablos;Maria T. Agapito;Regina Gutierrez;Jose M. Recio

  • Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver

    Dario Acuña-Castroviejo;Russel J. Reiter;Armando Menendez-Pelaez;Maria I. Pablos

  • Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats

    Germaine Escames;Josefa León;Manuel Macías;Huda Khaldy

  • Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience

    Antonio Molina-Carballo;Antonio Muñoz-Hoyos;Russel J. Reiter;Miguel Sánchez-Forte

  • Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

    José A. García;Huayqui Volt;Carmen Venegas;Carolina Doerrier

  • Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

    Josefa León;Germaine Escames;María I. Rodríguez;Luis C. López

Frequent Co-Authors

Germaine Escames
Germaine Escames University of Granada
Russel J. Reiter
Russel J. Reiter The University of Texas Health Science Center at San Antonio
Dun Xian Tan
Dun Xian Tan The University of Texas Health Science Center at San Antonio
Juan M. Guerrero
Juan M. Guerrero University of Seville
Ahmed E. Abdel Moneim
Ahmed E. Abdel Moneim Helwan University
Rosa M. Claramunt
Rosa M. Claramunt National University of Distance Education
Daniel P. Cardinali
Daniel P. Cardinali Pontifical Catholic University of Argentina
Coral Sanfeliu
Coral Sanfeliu Spanish National Research Council
José Manuel García-Verdugo
José Manuel García-Verdugo University of Valencia
Ibon Alkorta
Ibon Alkorta Spanish National Research Council

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