World's Best Scientists 2026 revealed!
Darío Acuña-Castroviejo

Darío Acuña-Castroviejo

D-Index & Metrics

Medicine

D-Index
84
Citations
24566
World Ranking
15159
National Ranking
215

Darío Acuña-Castroviejo publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where Darío Acuña-Castroviejo sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 611 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 276 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

Darío Acuña-Castroviejo D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where Darío Acuña-Castroviejo sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 400 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 84 D-Index — 27th percentile

27% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Overview

Darío Acuña-Castroviejo is affiliated with the University of Granada in Spain and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work spans several subfields, including endocrine and autonomic systems, molecular biology, physiology, cell biology, and cancer research.

The primary research topics covered by Darío Acuña-Castroviejo include circadian rhythm and melatonin, inflammasome and immune disorders, epigenetics and DNA methylation, muscle metabolism and nutrition, mitochondrial function and pathology, genetics, aging and longevity in model organisms, and microRNA in disease regulation.

Selected recent papers authored or coauthored by Darío Acuña-Castroviejo include:

  • Clinical trial to test the efficacy of melatonin in COVID-19, 2020, Journal of Pineal Research
  • The NLRP3 inflammasome: contributions to inflammation-related diseases, 2023, Cellular & Molecular Biology Letters
  • Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport, 2022, Journal of Pineal Research
  • Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging, 2020, Antioxidants
  • Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology

Darío Acuña-Castroviejo has collaborated frequently with several coauthors, including:

  • Germaine Escames
  • José Fernández-Martínez
  • Paula Aranda-Martínez
  • Iryna Rusanova
  • Laura Martínez-Ruiz

Their work has been published predominantly in several venues, with multiple publications appearing in:

  • Antioxidants
  • International Journal of Molecular Sciences
  • Preprints.org
  • Journal of Pineal Research
  • Biomedicines

Best Publications

  • Extrapineal melatonin: sources, regulation, and potential functions.

    Darío Acuña-Castroviejo;Germaine Escames;Carmen Venegas;María E. Díaz-Casado

  • Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

    Carmen Venegas;José A. García;Germaine Escames;Francisco Ortiz

  • Melatonin mitigates mitochondrial malfunction

    Josefa León;Darío Acuña-Castroviejo;Germane Escames;Dyn Xian Tan

  • Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system.

    Russel J. Reiter;Dario Acuña-Castroviejo;Dun Xian Tan;Susanne Burkhardt

  • Melatonin, mitochondria, and cellular bioenergetics.

    Darío Acuña-Castroviejo;Miguel Martín;Manuel Macías;Germaine Escames

  • Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress.

    Miguel Martín;Manuel Macías;Germaine Escames;Josefa León

  • Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

    Russel J. Reiter;Sergio A. Rosales-Corral;Dun Xian Tan;Dario Acuna-Castroviejo

  • Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

    M. Martín;M. Macías;G. Escames;Russel J Reiter

  • Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats

    Elena Crespo;Manuel Macías;David Pozo;Germaine Escames

  • Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin.

    Sergio A. Rosales-Corral;Dario Acuña-Castroviejo;Ana Coto-Montes;Jose A. Boga

  • Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria.

    Miguel Martı́n;Manuel Macı́as;Josefa León;Germaine Escames

  • Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

    Russell J. Reiter;Juan M. Guerrero;Joaquin J. Garcia;Dario Acuña-Castroviejo

  • Melatonin is protective against MPTP-induced striatal and hippocampal lesions.

    Dario Acuña-Castroviejo;Ana Coto-Montes;M.Gaia Monti;Genaro G. Ortiz

  • Melatonin reduces nitric oxide synthase activity in rat hypothalamus

    Ilham Bettahi;David Pozo;Carmen Osuna;Russel J. Reiter

  • Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks.

    Marta I. Pablos;Maria T. Agapito;Regina Gutierrez;Jose M. Recio

  • Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver

    Dario Acuña-Castroviejo;Russel J. Reiter;Armando Menendez-Pelaez;Maria I. Pablos

  • Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats

    Germaine Escames;Josefa León;Manuel Macías;Huda Khaldy

  • Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience

    Antonio Molina-Carballo;Antonio Muñoz-Hoyos;Russel J. Reiter;Miguel Sánchez-Forte

  • Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

    José A. García;Huayqui Volt;Carmen Venegas;Carolina Doerrier

  • Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

    Josefa León;Germaine Escames;María I. Rodríguez;Luis C. López

Frequent Co-Authors

Germaine Escames
Germaine Escames University of Granada
Russel J. Reiter
Russel J. Reiter The University of Texas Health Science Center at San Antonio
Dun Xian Tan
Dun Xian Tan The University of Texas Health Science Center at San Antonio
Juan M. Guerrero
Juan M. Guerrero University of Seville
Ahmed E. Abdel Moneim
Ahmed E. Abdel Moneim Helwan University
Rosa M. Claramunt
Rosa M. Claramunt National University of Distance Education
Daniel P. Cardinali
Daniel P. Cardinali Pontifical Catholic University of Argentina
Coral Sanfeliu
Coral Sanfeliu Spanish National Research Council
José Manuel García-Verdugo
José Manuel García-Verdugo University of Valencia
Ibon Alkorta
Ibon Alkorta Spanish National Research Council

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