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Rüdiger Hardeland

Rüdiger Hardeland

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
22159
World Ranking
7279
National Ranking
529

Overview

Rüdiger Hardeland is affiliated with the University of Göttingen in Germany and conducts research primarily in the fields of neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their work spans several subfields including endocrine and autonomic systems, molecular biology, neurology, infectious diseases, and biological psychiatry.

The research topics explored by Hardeland include circadian rhythm and melatonin, gut microbiota and health, tryptophan and brain disorders, neuroinflammation and neurodegeneration mechanisms, birth, development, and health, photoreceptor and optogenetics research, and the long-term effects of COVID-19.

Hardeland's frequent coauthors include Dun-Xian Tan, Russel J. Reíter, Wenkai Ren, Fang He, and Xiaoyan Wu. The researcher has published multiple papers in notable venues such as the International Journal of Molecular Sciences, Molecules, Melatonin Research, Theranostics, and Frontiers in Immunology.

  • Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens (2020, Theranostics)
  • Melatonin and Microglia (2021, International Journal of Molecular Sciences)
  • Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19 (2020, Molecules)
  • Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights (2021, Frontiers in Immunology)
  • Redox Biology of Melatonin: Discriminating Between Circadian and Noncircadian Functions (2022, Antioxidants and Redox Signaling)

Hardeland's work on circadian rhythm and melatonin is reflected in the majority of their research, often intersecting with topics such as neuroinflammation and neurodegeneration, and the long-term effects of viral infections including COVID-19. The research also integrates biochemical and molecular biological perspectives, especially regarding melatonin's physiological and cellular impacts.

They have a significant presence in journals focused on molecular sciences and melatonin research, contributing to the understanding of melatonin's various biological roles. The collaboration with other researchers such as Dun-Xian Tan and Fang He indicates a multidisciplinary approach to studying melatonin-related mechanisms and their implications for health.

Best Publications

  • Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.

    Dun xian Tan;Russel J. Reiter;Lucien C. Manchester;Mei ting Yan

  • Melatonin: Nature's most versatile biological signal?

    S R Pandi-Perumal;V Srinivasan;G J M Maestroni;D P Cardinali

  • Melatonin—A pleiotropic, orchestrating regulator molecule

    Rüdiger Hardeland;Daniel P. Cardinali;Venkatramanujam Srinivasan;D. Warren Spence

  • Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance.

    Rüdiger Hardeland

  • Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

    Dun Xian Tan;Rudiger Hardeland;Lucien C. Manchester;Ahmet Korkmaz

  • Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

    Dun Xian Tan;Lucien C. Manchester;Rüdiger Hardeland;Silvia Lopez-Burillo

  • Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

    Rüdigger Hardeland;Dun Xian Tan;Russel J. Reiter

  • Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling.

    Rüdiger Hardeland;Juan Antonio Madrid;Dun Xian Tan;Russel J. Reiter

  • Non-vertebrate melatonin

    Rüdiger Hardeland;Burkhard Poeggeler;Burkhard Poeggeler

  • Melatonin and inflammation—Story of a double‐edged blade

    Rüdiger Hardeland

  • Circadian rhythms, oxidative stress, and antioxidative defense mechanisms.

    Rüdiger Hardeland;Ana Coto-Montes;Burkhard Poeggeler

  • The changing biological roles of melatonin during evolution: From an antioxidant to signals of darkness, sexual selection and fitness

    Dun Xian Tan;Rüdiger Hardeland;Lucien C. Manchester;Sergio D. Paredes

  • Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.

    Juan C. Mayo;Rosa M. Sainz;Dun Xian Tan;Rüdiger Hardeland

  • Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.

    Seithikurippu R. Pandi-Perumal;Seithikurippu R. Pandi-Perumal;Ahmed S. BaHammam;Gregory M. Brown;Gregory M. Brown;D. Warren Spence

  • Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug

    Rüdiger Hardeland;SR Pandi-Perumal

  • Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

    Rüdiger Hardeland

  • Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.

    Jochen H. Weishaupt;Claudia Bartels;Esther Pölking;Jeannine Dietrich

  • N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant

    Dun-Xian Tan;Lucien C. Manchester;Susanne Burkhardt;Rosa M. Sainz

  • Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites.

    R. Hardeland

  • Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus).

    Susanne Burkhardt;Dun Xian Tan;Lucien C. Manchester;Rüdiger Hardeland

Frequent Co-Authors

Daniel P. Cardinali
Daniel P. Cardinali Pontifical Catholic University of Argentina
Dun Xian Tan
Dun Xian Tan The University of Texas Health Science Center at San Antonio
Russel J. Reiter
Russel J. Reiter The University of Texas Health Science Center at San Antonio
Gregory M. Brown
Gregory M. Brown University of Toronto
Hartmut Laatsch
Hartmut Laatsch University of Göttingen
Hannelore Ehrenreich
Hannelore Ehrenreich Central Institute of Mental Health
Miguel A. Pappolla
Miguel A. Pappolla The University of Texas Medical Branch at Galveston
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Mathias Bähr
Mathias Bähr University of Göttingen
Yulong Yin
Yulong Yin Chinese Academy of Sciences

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