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Frederick M. Hughson

Frederick M. Hughson

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
13966
World Ranking
18563
National Ranking
7586

Overview

Frederick M. Hughson is affiliated with Princeton University in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Cell Biology and Molecular Biology. Their work also extends into Renewable Energy, Sustainability and the Environment, Atomic and Molecular Physics, and Physiology.

Hughson's research covers a range of topics including cellular transport and secretion, lipid membrane structure and behavior, photosynthetic processes and mechanisms, endoplasmic reticulum stress and disease, microtubule and mitosis dynamics, algal biology and biofuel production, and spectroscopy and quantum chemical studies.

Significant recent publications include:

  • The structural basis of Rubisco phase separation in the pyrenoid (2020, Nature Plants)
  • Chaperoning SNARE Folding and Assembly (2021, Annual Review of Biochemistry)
  • The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation (2020, eLife)
  • The machinery of vesicle fusion (2023, Current Opinion in Cell Biology)
  • Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1 (2020, Journal of Biological Chemistry)

Their research has been published frequently in venues including bioRxiv (Cold Spring Harbor Laboratory), Nature Plants, Annual Review of Biochemistry, Current Opinion in Cell Biology, and eLife.

Hughson collaborates regularly with several co-authors, who include:

  • Philip D. Jeffrey
  • Sophie M. Travis
  • Kevin DAmico
  • Sarah A. Port
  • Abigail E. Stanton

Best Publications

  • Structure of influenza haemagglutinin at the pH of membrane fusion

    Per A. Bullough;Frederick M. Hughson;John J. Skehel;Don C. Wiley;Don C. Wiley

  • Structural identification of a bacterial quorum-sensing signal containing boron

    Xin Chen;Stephan Schauder;Noelle Potier;Alain Van Dorsselaer

  • Structural characterization of a partly folded apomyoglobin intermediate.

    Frederick McLaury Hughson;Peter E. Wright;Robert L. Baldwin

  • Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2

    Stephen T. Miller;Karina B. Xavier;Shawn R. Campagna;Michiko E. Taga

  • SNARE Protein Structure and Function

    Daniel Ungar;Frederick McLaury Hughson

  • Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion

    Chavela M. Carr;Eric Grote;Mary Munson;Frederick McLaury Hughson

  • Tethering factors as organizers of intracellular vesicular traffic.

    I-Mei Yu;Frederick M Hughson

  • Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.

    Matthew B. Neiditch;Michael J. Federle;Michael J. Federle;Audra J. Pompeani;Robert C. Kelly

  • A Strategy for Antagonizing Quorum Sensing

    Guozhou Chen;Lee R. Swem;Lee R. Swem;Danielle L. Swem;Danielle L. Swem;Devin L. Stauff;Devin L. Stauff

  • A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

    Richard W. Baker;Philip D. Jeffrey;Michael Zick;Ben P. Phillips

  • Regulation of LuxPQ Receptor Activity by the Quorum-Sensing Signal Autoinducer-2

    Matthew B. Neiditch;Michael J. Federle;Stephen T. Miller;Bonnie Lynn Bassler

  • Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p

    Karin L. Nicholson;Mary Munson;Rebecca B. Miller;Rebecca B. Miller;Thomas J. Filip

  • Chaperoning SNARE assembly and disassembly.

    Richard W. Baker;Frederick M. Hughson

  • The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy

    Wei Lien Yen;Takahiro Shintani;Usha Nair;Yang Cao

  • Probing the Stability of a Partly Folded Apomyoglobin Intermediate by Site-Directed Mutagenesis?

    Frederick McLaury Hughson;Doug Barrick;Robert L. Baldwin

  • A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation.

    Jue Chen;Stephen A. Wharton;Winfried Weissenhorn;Lesley J. Calder

  • Enveloped viruses: A common mode of membrane fusion?

    Frederick McLaury Hughson

  • Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly.

    Mary Munson;Xin Chen;Amy E. Cocina;Susan M. Schultz

  • A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1

    Yi Ren;Calvin K. Yip;Arati Tripathi;David Huie

  • Molecular Mechanisms of Acid Denaturation: The Role of Histidine Residues in the Partial Unfolding of Apomyoglobin

    Doug Barrick;Frederick M. Hughson;Robert L. Baldwin

Frequent Co-Authors

Philip D. Jeffrey
Philip D. Jeffrey Princeton University
Bonnie L. Bassler
Bonnie L. Bassler Princeton University
Thomas Walz
Thomas Walz Rockefeller University
Robert L. Baldwin
Robert L. Baldwin Stanford University
Robert Fairman
Robert Fairman Haverford College
Don C. Wiley
Don C. Wiley Harvard University
Martin F. Semmelhack
Martin F. Semmelhack Princeton University
Josep Rizo
Josep Rizo The University of Texas Southwestern Medical Center
John J. Skehel
John J. Skehel The Francis Crick Institute

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