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Germaine Escames

Germaine Escames

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
16980
World Ranking
5702
National Ranking
80

Overview

Germaine Escames is affiliated with the University of Granada in Spain and has a research focus spanning several interconnected fields within life sciences. Their body of work significantly contributes to the study of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. This multidisciplinary approach covers both broad biological mechanisms and their implications in health and disease.

Their notable subfields of study include Molecular Biology, Endocrine and Autonomic Systems, Physiology, Cancer Research, and Oncology. These areas reflect an emphasis on understanding cellular and molecular processes and their impact on systemic physiology and pathology.

Escames's work addresses several main topics, among which Circadian rhythm and melatonin are the most prominent. Other primary research interests include inflammasome and immune disorders, mitochondrial function and pathology, epigenetics and DNA methylation, cancer, hypoxia, and metabolism, tryptophan and brain disorders, and genetics, aging, and longevity in model organisms.

Frequent publication venues for Escames's research include:

  • Antioxidants
  • International Journal of Molecular Sciences
  • Journal of Pineal Research
  • Preprints.org
  • bioRxiv (Cold Spring Harbor Laboratory)

Prominent recent publications authored or co-authored by Escames are:

  • The NLRP3 inflammasome: contributions to inflammation-related diseases (2023, Cellular & Molecular Biology Letters)
  • Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport (2022, Journal of Pineal Research)
  • Clinical trial to test the efficacy of melatonin in COVID-19 (2020, Journal of Pineal Research)
  • Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging (2020, Antioxidants)
  • Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome (2020, Naunyn-Schmiedeberg's Archives of Pharmacology)

Their collaborative network includes frequent co-authors such as Darío Acuña-Castroviejo, Laura Martínez-Ruiz, Alba López-Rodríguez, Javier Florido, and José Fernández-Martínez, highlighting ongoing partnerships in advancing research within their domains of expertise.

Best Publications

  • Extrapineal melatonin: sources, regulation, and potential functions.

    Darío Acuña-Castroviejo;Germaine Escames;Carmen Venegas;María E. Díaz-Casado

  • Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

    Carmen Venegas;José A. García;Germaine Escames;Francisco Ortiz

  • Melatonin mitigates mitochondrial malfunction

    Josefa León;Darío Acuña-Castroviejo;Germane Escames;Dyn Xian Tan

  • Melatonin, mitochondria, and cellular bioenergetics.

    Darío Acuña-Castroviejo;Miguel Martín;Manuel Macías;Germaine Escames

  • Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress.

    Miguel Martín;Manuel Macías;Germaine Escames;Josefa León

  • Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation

    Joaquı́n J Garcı́a;Russel J Reiter;Juan M Guerrero;Germaine Escames

  • Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

    M. Martín;M. Macías;G. Escames;Russel J Reiter

  • Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production.

    Ana López;José A. García;Germaine Escames;Carmen Venegas

  • Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria.

    Miguel Martı́n;Manuel Macı́as;Josefa León;Germaine Escames

  • Melatonin-mitochondria Interplay in Health and Disease

    Dario Acuna Castroviejo;Luis C. Lopez;Germaine Escames;Ana Lopez

  • Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats

    Germaine Escames;Josefa León;Manuel Macías;Huda Khaldy

  • Cell protective role of melatonin in the brain.

    Darfo Acufla-Castroviejo;Germaine Escames;Manuel Macks;Antono Muñóz Hoyos

  • Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

    Josefa León;Germaine Escames;María I. Rodríguez;Luis C. López

  • Melatonin, mitochondrial homeostasis and mitochondrial-related diseases.

    Dario Acuna Castroviejo;Germaine Escames;Angel Carazo;Josefa Leon

  • Melatonin role in the mitochondrial function.

    Dario Acuna-Castroviejo;Germaine Escames;Maria I Rodriguez;Luis C Lopez

  • Exercise and melatonin in humans: reciprocal benefits

    Germaine Escames;Guler Ozturk;Beatriz Baño-Otálora;María J. Pozo

  • Mitochondrial regulation by melatonin And its metabolites

    Dario Acuña-Castroviejo;Germaine Escames;Josefa LeÓn;Angel Carazo

  • Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

    Ying Qiang Shen;Ana Guerra-Librero;Beatriz I. Fernandez-Gil;Javier Florido

  • Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice

    Germaine Escames;Luis C. López;Víctor Tapias;Pilar Utrilla

  • Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

    Francisco Ortiz;Darío Acuña-Castroviejo;Carolina Doerrier;José C. Dayoub

Frequent Co-Authors

Darío Acuña-Castroviejo
Darío Acuña-Castroviejo University of Granada
Russel J. Reiter
Russel J. Reiter The University of Texas Health Science Center at San Antonio
Dun Xian Tan
Dun Xian Tan The University of Texas Health Science Center at San Antonio
Juan M. Guerrero
Juan M. Guerrero University of Seville
Ahmed E. Abdel Moneim
Ahmed E. Abdel Moneim Helwan University
José Manuel García-Verdugo
José Manuel García-Verdugo University of Valencia
Holger Prokisch
Holger Prokisch Technical University of Munich
Rosa M. Claramunt
Rosa M. Claramunt National University of Distance Education
Raquel Osorio
Raquel Osorio University of Granada
Manuel Toledano
Manuel Toledano University of Granada

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