His primary scientific interests are in Melatonin, Endocrinology, Internal medicine, Pineal gland and Immune system. His work deals with themes such as Free radical scavenger, Molecular biology, Biochemistry and Nitric oxide, which intersect with Melatonin. His research integrates issues of Cytokine and Cell biology in his study of Endocrinology.
When carried out as part of a general Internal medicine research project, his work on Paracrine Communication is frequently linked to work in Tryptophan hydroxylase, therefore connecting diverse disciplines of study. He works mostly in the field of Pineal gland, limiting it down to topics relating to Spleen and, in certain cases, Lymphocyte and Binding site. His Immune system research includes elements of Inflammation and Proinflammatory cytokine.
Juan R. Calvo mainly focuses on Internal medicine, Endocrinology, Melatonin, Vasoactive intestinal peptide and Receptor. His work carried out in the field of Internal medicine brings together such families of science as Peripheral blood mononuclear cell and Antioxidant. Juan R. Calvo combines subjects such as Neuropeptide and Binding site with his study of Endocrinology.
The various areas that he examines in his Melatonin study include Cell surface receptor and Immune system. His Vasoactive intestinal peptide study combines topics in areas such as GTP', Somatostatin, Adenylate kinase and Peptide. The study incorporates disciplines such as Molecular biology and Harderian gland in addition to Receptor.
Juan R. Calvo mainly investigates Melatonin, Internal medicine, Endocrinology, Immune system and Pineal gland. His Melatonin study incorporates themes from Oxidative stress, Cytokine, Antioxidant, Cell biology and Cell surface receptor. Juan R. Calvo has researched Endocrinology in several fields, including Proinflammatory cytokine and Colitis.
His Immune system study combines topics from a wide range of disciplines, such as Inflammation, Mast cell, Pharmacology and Mechanism of action. Juan R. Calvo has researched Pharmacology in several fields, including Vasoactive intestinal peptide receptor, Vasoactive intestinal peptide, Spleen and Effector. In his research, Endocrine system and In vitro is intimately related to Immunology, which falls under the overarching field of Pineal gland.
Juan R. Calvo mostly deals with Melatonin, Internal medicine, Endocrinology, Pineal gland and Cell surface receptor. His study in the field of Luzindole also crosses realms of In vivo. His work deals with themes such as Ethanol, Alcohol and Antioxidant, which intersect with Internal medicine.
His Endocrinology study integrates concerns from other disciplines, such as Paracrine Communication and Toxicity. His studies deal with areas such as Local hormone, Intracrine and Autocrine signalling as well as Pineal gland. His Immune system research is multidisciplinary, relying on both Peroxynitrite, Cell migration, Inflammation, Proinflammatory cytokine and Cell adhesion molecule.
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Significance of melatonin in antioxidative defense system: reactions and products.
Dun Xian Tan;Lucien C. Manchester;Russel J. Reiter;Wen Bo Qi.
Neurosignals (2000)
Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
Antonio Carrillo-Vico;Juan R. Calvo;Pedro Abreu;Patricia J. Lardone.
The FASEB Journal (2004)
Melatonin and its relation to the immune system and inflammation.
Russel J. Reiter;Juan R. Calvo;Malgorzata Karbownik;Wenbo Qi.
Annals of the New York Academy of Sciences (2006)
Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes.
S Garcia-Mauriño;M G Gonzalez-Haba;J R Calvo;M Rafii-El-Idrissi.
Journal of Immunology (1997)
Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin.
David Pozo;Russel J. Reiter;Juan R. Calvo;Juan M. Guerrero.
Journal of Cellular Biochemistry (1997)
Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo.
Russel J. Reiter;Dun Xian Tan;Wenbo Qi;Lucien C. Manchester.
Biological Signals and Receptors (2000)
The role of melatonin in the cells of the innate immunity: a review
Juan R. Calvo;C. González-Yanes;M. D. Maldonado.
Journal of Pineal Research (2013)
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum.
David Pozo;Russel J. Reiter;Juan R. Calvo;Juan M. Guerrero.
Life Sciences (1994)
Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects.
Antonio Carrillo-Vico;Patricia J. Lardone;Latifa Naji;José M. Fernández-Santos.
Journal of Pineal Research (2005)
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6
Mario Delgado;Mario Delgado;Carmen Martinez;David Pozo;Juan R. Calvo.
Journal of Immunology (1999)
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