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Nancy H. Ruddle

Nancy H. Ruddle

D-Index & Metrics

Immunology

D-Index
77
Citations
21206
World Ranking
1823
National Ranking
897

Medicine

D-Index
77
Citations
21204
World Ranking
18455
National Ranking
9206

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Nancy H. Ruddle is affiliated with Yale University in the United States and specializes in research primarily within the fields of Immunology and Microbiology as well as Medicine. Their scholarly work spans multiple subfields including Immunology, Surgery, Molecular Biology, Oncology, and Physiology.

The researcher's main topics of study focus on immune system dynamics and related cellular pathways. Areas of interest include Immune Cell Function and Interaction, IL-33, ST2, and ILC Pathways, T-cell and B-cell Immunology, Immunotherapy and Immune Responses, Immune cells in cancer, Transplantation: Methods and Outcomes, and Angiogenesis and VEGF in Cancer.

Recent publications provide insight into this scientific focus. Key papers include:

  • Basics of Inducible Lymphoid Organs (2020) published in Current topics in microbiology and immunology
  • Posttransplant Tertiary Lymphoid Organs (2023) published in Transplantation
  • Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer (2023) published in Current Opinion in Physiology
  • Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy (2021) published in PLoS Computational Biology
  • Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production (2020) published in European Journal of Immunology

Throughout their career, Nancy H. Ruddle has collaborated with various coauthors, including Chad R. Wells, Youfang Cao, David P. Durham, Siddappa N. Byrareddy, and Aftab A. Ansari. The researcher has contributed to works published in journals such as Current topics in microbiology and immunology, Transplantation, Current Opinion in Physiology, PLoS Computational Biology, and Methods in molecular biology.

Their expertise also extends into the study of immune system responses related to transplantation, cancer, and inflammation, reflecting a multidisciplinary approach in biological and medical sciences.

Nancy H. Ruddle was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2014.

Best Publications

  • Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

    Pietro De Togni;Joseph Goellner;Nancy H. Ruddle;Philip R. Streeter

  • ICOS co-stimulatory receptor is essential for T-cell activation and function.

    Chen Dong;Amy E. Juedes;Ulla Angela Temann;Ulla Angela Temann;Sujan Shresta

  • Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

    Jody L. Baron;Joseph A. Madri;Nancy H. Ruddle;George Hashim

  • An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

    N H Ruddle;C M Bergman;K M McGrath;E G Lingenheld

  • Lymphoid organ development: from ontogeny to neogenesis

    Danielle L Drayton;Shan Liao;Rawad H Mounzer;Nancy H Ruddle

  • Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

    Pandelakis A Koni;Rosalba Sacca;Pornsri Lawton;Jeffrey L Browning

  • Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

    K C Sheehan;N H Ruddle;R D Schreiber

  • Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

    A Kratz;A Campos-Neto;M S Hanson;N H Ruddle

  • CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY : III. ANALYSIS OF MECHANISM

    Nancy H. Ruddle;Byron H. Waksman

  • Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.

    Donnasue Graesser;Anna Solowiej;Monika Bruckner;Emily Osterweil

  • Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

    Lynn Soong;Jian Chao Xu;Iqbal S. Grewal;Peter Kima

  • Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity.

    Marianne Broome Powell;Dennis Mitchell;Jennifer Lederman;Julie Buckmeier

  • Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response

    Nancy H. Ruddle;Eitan M. Akirav

  • Impaired lymphatic contraction associated with immunosuppression

    Shan Liao;Gang Cheng;David A. Conner;Yuhui Huang

  • Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase

    Danielle L. Drayton;Xiaoyan Ying;Jason Lee;Werner Lesslauer

  • Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. I. Characterization of the phenomenon.

    Nancy H. Ruddle;Byron H. Waksman

  • B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization.

    Peter Hjelmström;Amy E. Juedes;Jenny Fjell;Nancy H. Ruddle

  • Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

    Nancy H. Ruddle;Byron H. Waksman

  • Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice.

    Alfred R. Oliver;Geoffrey M. Lyon;Nancy H. Ruddle

  • Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and development.

    Nancy H. Ruddle

  • Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

    Ruddle Nh

Frequent Co-Authors

Richard A. Flavell
Richard A. Flavell Yale University
Peter J. Krause
Peter J. Krause Yale University
Frank H. Ruddle
Frank H. Ruddle Yale University
Diane McMahon-Pratt
Diane McMahon-Pratt Yale University
Lynn Soong
Lynn Soong The University of Texas Medical Branch at Galveston
Werner Lesslauer
Werner Lesslauer Yale University
Jeffrey L. Browning
Jeffrey L. Browning Boston University
Yang-Xin Fu
Yang-Xin Fu Tsinghua University
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Kevan C. Herold
Kevan C. Herold Yale University

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