Werner Lesslauer

Best Publications

• THE TRANSMEMBRANE FORM OF TUMOR NECROSIS FACTOR IS THE PRIME ACTIVATING LIGAND OF THE 80 KDA TUMOR NECROSIS FACTOR RECEPTOR

  Matthias Grell;Eleni Douni;Harald Wajant;Matthias Löhden

  1744
  Citations

• Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

  Joachim Rothe;Werner Lesslauer;Hansruedi Lötscher;Yolande Lang

  1536
  Citations

• Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

  David W. Banner;Allan D'Arcy;Wolfgang Janes;Reiner Gentz

  1528
  Citations

• Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.

  Hansruedi Loetscher;Yu-Ching E. Pan;Hans-Werner Lahm;Reiner Gentz

  1322
  Citations

• Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

  Manfred Brockhaus;Hans-Joachim Schoenfeld;Ernst-Juergen Schlaeger;Willi Hunziker

  1046
  Citations

• Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.

  Fabienne Mackay;Hansruedi Loetscher;Dietrich Stueber;Gisela Gehr

  504
  Citations

• Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes

  Jean Da Silva;Benoit Pierrat;Jean-Luc Mary;Werner Lesslauer

  432
  Citations

• Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients.

  Edward Abraham;Pierre-François Laterre;Jorge Garbino;Susan Pingleton

  405
  Citations

• TWO HUMAN TNF RECEPTORS HAVE SIMILAR EXTRACELLULAR, BUT DISTINCT INTRACELLULAR, DOMAIN SEQUENCES

  Zlatko Dembic;Hansruedi Loetscher;Ueli Gubler;Yu-Ching E. Pan

  352
  Citations

• Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

  H Loetscher;D Stueber;D Banner;F Mackay

  340
  Citations

• Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality.

  Werner Lesslauer;Hisahiro Tabuchi;Reiner Gentz;Manfred Brockhaus

  332
  Citations

• Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.

  P F Piguet;G E Grau;C Vesin;H Loetscher

  311
  Citations

• Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase

  Danielle L. Drayton;Xiaoyan Ying;Jason Lee;Werner Lesslauer

  284
  Citations

• Human TNF mutants with selective activity on the p55 receptor

  Xaveer Van Ostade;Peter Vandenabeele;Bart Everaerdt;Hansruedi Loetscher

  283
  Citations

• Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice.

  L Mori;S Iselin;G De Libero;W Lesslauer

  261
  Citations

• Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.

  H. Loetscher;R. Gentz;M. Zulauf;A. Lustig

  251
  Citations

• Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

  M R Shalaby;A Sundan;H Loetscher;M Brockhaus

  229
  Citations

• Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.

  G Gehr;R Gentz;M Brockhaus;H Loetscher

  227
  Citations

• Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis.

  T J Evans;D Moyes;A Carpenter;R Martin

  206
  Citations

• TNF-α receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview

  W.E.F Klinkert;K Kojima;W Lesslauer;W Rinner

  203
  Citations