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Immunology
Spain
2022

D-Index & Metrics

Immunology

D-Index
87
Citations
20398
World Ranking
1225
National Ranking
13

Medicine

D-Index
87
Citations
20538
World Ranking
13818
National Ranking
195

Research.com Recognitions

  • 2022 - Research.com Immunology in Spain Leader Award

Overview

Mario Delgado is affiliated with the Spanish National Research Council in Spain. Their research spans multiple fields within biomedical sciences, with a significant focus on medicine as well as biochemistry, genetics, and molecular biology.

Their work covers key subfields including molecular biology, neurology, physiology, genetics, and oncology. Main research topics for Delgado encompass neuroinflammation and neurodegeneration mechanisms, mesenchymal stem cell research, Parkinson's disease mechanisms and treatments, histone deacetylase inhibitors research, cellular transport and secretion, lysosomal storage disorders research, and systemic lupus erythematosus research.

Delgado has contributed to several recent publications:

  • Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity, 2020, Journal for ImmunoTherapy of Cancer
  • Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease, 2021, Nature Communications
  • Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases, 2021, European Journal of Medicinal Chemistry
  • A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells, 2024, npj Parkinson s Disease
  • Protective role of cortistatin in pulmonary inflammation and fibrosis, 2021, British Journal of Pharmacology

Frequent collaborators include Elena González-Rey, Marta Caro, Raquel Benítez, Francisco O'Valle, and Jenny Campos-Salinas.

Delgado's publications are spread across various scientific journals with multiple contributions in Pharmaceutics, British Journal of Pharmacology, International Journal of Molecular Sciences, bioRxiv (Cold Spring Harbor Laboratory), and Research Square (Research Square).

In addition to journal articles, Delgado has contributed to book publications, notably a title published by UNESCO in 2024: Compendio de Estrategias para la Promoción del Compromiso Escolar y Factores Contextuales. Aportes desde la evidencia científica.

Best Publications

  • Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

    E Gonzalez-Rey;P Anderson;M A González;L Rico

  • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses.

    Manuel A. González;Elena Gonzalez–Rey;Laura Rico;Dirk Büscher

  • Treatment of experimental arthritis by inducing immune tolerance with human adipose‐derived mesenchymal stem cells

    Manuel A. González;Elena Gonzalez-Rey;Laura Rico;Dirk Büscher

  • Human adipose-derived mesenchymal stem cells reduce inflammatory and T-cell responses and induce regulatory T cells in vitro in rheumatoid arthritis

    Elena Gonzalez-Rey;Manuel A Gonzalez;Nieves Varela;Francisco O'Valle

  • The Significance of Vasoactive Intestinal Peptide in Immunomodulation

    Mario Delgado;David Pozo;Doina Ganea

  • Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease.

    Mario Delgado;Catalina Abad;Carmen Martinez;Javier Leceta

  • Requirement of IFN-γ–Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose–Derived Stem Cells

    Olga DelaRosa;Eleuterio Lombardo;Aitor Beraza;Pablo Mancheño-Corvo

  • Therapeutic Action of Ghrelin in a Mouse Model of Colitis

    Elena Gonzalez–Rey;Alejo Chorny;Mario Delgado

  • Regulation of immune tolerance by anti-inflammatory neuropeptides

    Elena Gonzalez-Rey;Alejo Chorny;Mario Delgado

  • Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease

    Catalina Abad;Carmen Martinez;Maria G. Juarranz;Alicia Arranz

  • Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis

    Per Anderson;Luciana Souza-Moreira;Maria Morell;Marta Caro

  • Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response Element-binding Protein/c-Jun

    Mario Delgado;Ernesto J. Munoz-Elias;Yanqing Kan;Illana Gozes

  • Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation.

    Mario Delgado;Ernesto J. Munoz-Elias;Rosa P. Gomariz;Doina Ganea

  • Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Enhance IL-10 Production by Murine Macrophages: In Vitro and In Vivo Studies

    Mario Delgado;Ernesto J. Munoz-Elias;Rosa P. Gomariz;Doina Ganea

  • Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6

    Mario Delgado;Mario Delgado;Carmen Martinez;David Pozo;Juan R. Calvo

  • Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.

    Mario Delgado;Doina Ganea

  • Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells

    Elena Gonzalez-Rey;Alejo Chorny;Alejo Chorny;Amelia Fernandez-Martin;Amelia Fernandez-Martin;Doina Ganea;Doina Ganea

  • Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

    Juan Carlos Sepúlveda;María Tomé;María Eugenia Fernández;Mario Delgado

  • Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson's disease by blocking microglial activation.

    Mario Delgado;Doina Ganea

  • Immunology of VIP: A Review and Therapeutical Perspectives

    R.P. Gomariz;C. Martinez;C. Abad;J. Leceta

  • VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T cells

    Mario Delgado;Mario Delgado;Ernesto J Munoz-Elias;Rosa P Gomariz;Doina Ganea

  • Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders

    Alejo Chorny;Elena Gonzalez-Rey;Amelia Fernandez-Martin;David Pozo

Frequent Co-Authors

Elena Gonzalez-Rey
Elena Gonzalez-Rey Spanish National Research Council
Rosa P. Gomariz
Rosa P. Gomariz Complutense University of Madrid
Carmen Martinez Mora
Carmen Martinez Mora Complutense University of Madrid
Javier Leceta
Javier Leceta Complutense University of Madrid
Doina Ganea
Doina Ganea Temple University
Pablo Menendez
Pablo Menendez University of Barcelona
Juan R. Calvo
Juan R. Calvo University of Seville
Mónica De la Fuente
Mónica De la Fuente Complutense University of Madrid
Antonio Bernad
Antonio Bernad Spanish National Research Council
Luis de Lecea
Luis de Lecea Stanford University

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