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Biology and Biochemistry

D-Index
50
Citations
7299
World Ranking
17765
National Ranking
788

Overview

Alain Couvineau is affiliated with Université Paris Cité in France and is active in research primarily within neuroscience, biochemistry, genetics and molecular biology, and medicine. Their work encompasses various subfields including cognitive neuroscience, molecular biology, endocrine and autonomic systems, experimental and cognitive psychology, and surgery.

The main topics addressed in their research include:

  • Sleep and Wakefulness Research
  • Sleep and related disorders
  • Receptor Mechanisms and Signaling
  • Circadian rhythm and melatonin
  • Neuropeptides and Animal Physiology
  • Pancreatic function and diabetes
  • Regulation of Appetite and Obesity

Their most recent publications span from 2021 to 2022 and include the following:

  • "Signal Transduction by VIP and PACAP Receptors," 2022, published in Biomedicines
  • "The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment," 2022, published in Frontiers in Oncology
  • "The Orexin receptors: Structural and anti-tumoral properties," 2022, published in Frontiers in Endocrinology
  • "Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions," 2021, published in World Journal of Gastroenterology
  • "Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target," 2021, published in Molecules

Frequent coauthors collaborating with Alain Couvineau include:

  • Thierry Voisin
  • Valérie Gratio
  • Pascal Nicole
  • Anne Blais
  • Dorota Latek

A number of journals regularly feature their research, with multiple publications in the following venues:

  • Frontiers in Endocrinology
  • International Journal of Molecular Sciences
  • Nutrition Clinique et Métabolisme
  • Biomedicines
  • Frontiers in Oncology

Alain Couvineau's research focuses largely on receptor mechanisms associated with neuropeptides, particularly orexins, and their involvement in cancer, metabolism, inflammation, and sleep regulation. Their work integrates molecular and cellular approaches to understanding signaling pathways and potential therapeutic targets especially in pancreatic cancer and metabolic disorders.

Best Publications

  • Novel Receptor Partners and Function of Receptor Activity-modifying Proteins

    Arthur Christopoulos;George Christopoulos;Maria Morfis;Madhara Udawela

  • Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.

    A S Jobert;P Zhang;A Couvineau;J Bonaventure

  • Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology

    Marc Laburthe;Alain Couvineau;Var Tan

  • VPAC Receptors for VIP and PACAP

    M. Laburthe;A. Couvineau;J.-C. Marie

  • Receptors for VIP, PACAP, Secretin, GRF, Glucagon, GLP‐1, and Other Members of Their New Family of G Protein‐Linked Receptors: Structure‐Function Relationship with Special Reference to the Human VIP‐1 Receptora

    Marc Laburthe;Alain Couvineau;Pascale Gaudin;Jean-José Maoret

  • Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP.

    M Laburthe;A Couvineau

  • Recurrent PRKAR1A Mutation in Acrodysostosis with Hormone Resistance

    Agnès Linglart;Christine Menguy;Alain Couvineau;Colette Auzan

  • Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains.

    A. Couvineau;C. Rouyerfessard;D. Darmoul;J.J. Maoret

  • Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.

    Pascal Nicole;Laurence Lins;Christiane Rouyer-Fessard;Cyrille Drouot

  • A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.

    Ping Zhang;Anne-Sixtine Jobert;Alain Couvineau;Carline Silve

  • Interaction of peptide YY with rat intestinal epithelial plasma membranes: binding of the radioiodinated peptide

    Marc Laburthe;Bernard Chenut;Christiane Rouyer-Fessard;Kazuhiko Tatemoto

  • Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane.

    Alain Couvineau;Catherine Fabre;Pascale Gaudin;Jean-José Maoret

  • Novel stable PACAP analogs with potent activity towards the PAC1 receptor.

    Steve Bourgault;David Vaudry;David Vaudry;Béatrice Botia;Béatrice Botia;Alain Couvineau

  • VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins

    Alain Couvineau;Marc Laburthe

  • PTHR1 mutations associated with Ollier disease result in receptor loss of function

    Alain Couvineau;Vinciane Wouters;Guylène Bertrand;Christiane Rouyer

  • Galanin Receptors in a Hamster Pancreatic β-Cell Tumor: Identification and Molecular Characterization

    Brigitte Amiranoff;Alain L. Servin;Christiane Rouyer-Fessard;Alain Couvineau

  • Solubilization of the liver vasoactive intestinal peptide receptor. Hydrodynamic characterization and evidence for an association with a functional GTP regulatory protein.

    A Couvineau;B Amiranoff;M Laburthe

  • Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP.

    A. Couvineau;P. Gaudin;J.J. Maoret;C. Rouyerfessard

  • Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.

    Steve Bourgault;David Vaudry;Isabelle Ségalas-Milazzo;Laure Guilhaudis

  • A Heterotrimeric G i3-protein Controls Autophagic Sequestration in the Human Colon Cancer Cell Line HT-29 (∗)

    Eric Ogier-Denis;Alain Couvineau;Jean José Maoret;Jean Jacques Houri

Frequent Co-Authors

Alain Fournier
Alain Fournier Institut National de la Recherche Scientifique
Anne Couvelard
Anne Couvelard Université Paris Cité
David Vaudry
David Vaudry Inserm : Institut national de la santé et de la recherche médicale
Hubert Vaudry
Hubert Vaudry University of Rouen
Valérie Paradis
Valérie Paradis Université Paris Cité
Laurence Lins
Laurence Lins Gembloux Agro-Bio Tech
Alain L. Servin
Alain L. Servin Grenoble Alpes University

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