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Wen-Hwa Lee

Wen-Hwa Lee

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Molecular Biology
Taiwan
2026
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Genetics and Molecular Biology
Taiwan
2024

D-Index & Metrics

Molecular Biology

D-Index
98
Citations
41968
World Ranking
566
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Taiwan Leader Award
  • 2025 - Research.com Molecular Biology in Taiwan Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Taiwan Leader Award
  • 2023 - Research.com Molecular Biology in Taiwan Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Taiwan Leader Award
  • 2018 - Fellow, The World Academy of Sciences
  • 2014 - Fellow, National Academy of Inventors
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Wen-Hwa Lee is affiliated with Academia Sinica in Taiwan and focuses on research intersecting medicine and biochemistry, genetics, and molecular biology. Their work predominantly addresses topics within molecular biology, ophthalmology, radiology, nuclear medicine and imaging, immunology, and cancer research.

Their research topics include:

  • Retinal Diseases and Treatments
  • Retinal Imaging and Analysis
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Immunotherapy and Immune Responses
  • Gut microbiota and health
  • Bone Metabolism and Diseases

Wen-Hwa Lee has contributed to multiple scientific publications in various venues. Frequent outlets for their work include:

  • British Journal of Ophthalmology
  • SID Symposium Digest of Technical Papers
  • British Journal of Pharmacology
  • Asian Journal of Andrology

Notable recent papers authored or co-authored by Wen-Hwa Lee cover diverse topics such as emerging therapies for age-related macular degeneration and immunotherapy approaches in cancer treatment. Selected papers include:

  • "Emerging therapies and their delivery for treating age-related macular degeneration," 2021, British Journal of Pharmacology
  • "Clinical significance of EPHX2 deregulation in prostate cancer," 2020, Asian Journal of Andrology
  • "Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study," 2022, British Journal of Ophthalmology
  • "Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation," 2020, OncoImmunology
  • "A secreted pore-forming protein modulates cellular endolysosomes to augment antigen presentation," 2020, The FASEB Journal

Collaborative efforts have been an important aspect of Wen-Hwa Lee's research activity. Frequent co-authors include:

  • Alastair K. Denniston
  • Pearse A. Keane
  • Nicola J. Adderley
  • Jesse Coker
  • Krishnarajah Nirantharakumar

Wen-Hwa Lee's professional recognition comprises fellowships awarded by several scientific bodies, including:

  • Fellow, The World Academy of Sciences (2018)
  • Fellow, National Academy of Inventors (2014)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2012)

Best Publications

  • The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

    Tim Durfee;Kathleen Becherer;Phang Lang Chen;Shiou Hwei Yeh

  • Human retinoblastoma susceptibility gene: cloning, identification, and sequence

    Wen-Hwa Lee;Robert Bookstein;Frank Hong;Lih-Jiuan Young

  • SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

    James A. DeCaprio;John W. Ludlow;James Figge;Jin-Yuh Shew

  • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

    Eva Y.-H. P. Lee;Chi-Yao Chang;Nanpin Hu;Yi-Chun J. Wang

  • Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.

    Phang-Lang Chen;Peter Scully;Jin-Yuh Shew;Jean Y.J. Wang

  • Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

    Huei-Jen Su Huang;Jiing-Kuan Yee;Jin-Yuh Shew;Phang-Lang Chen

  • The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

    David W. Goodrich;Nan Ping Wang;Yue-Wei Qian;Eva Y.-H.P. Lee

  • The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

    Wen-Hwa Lee;Jin-Yuh Shew;Frank D. Hong;Theodore W. Sery

  • BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

    Haijuan Yang;Philip D. Jeffrey;Julie Miller;Elspeth Kinnucan

  • Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene

    Robert Bookstein;Jin-Yuh Shew;Phang-Lang Chen;Peter Scully

  • Inactivation of the retinoblastoma susceptibility gene in human breast cancers.

    Eva Y.H.P. Lee;Hoang To;Jin Yuh Shew;Robert Bookstein

  • Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

    Qing Zhong;Chi Fen Chen;Shang Li;Yumay Chen

  • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

    Bei Shan;Wen-Hwa Lee

  • Genetic mechanisms of tumor suppression by the human p53 gene.

    Phang-Lang Chen;Yumay Chen;Robert Bookstein;Wen-Hwa Lee

  • SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family.

    John W. Ludlow;James A. DeCaprio;Chun-Ming Huang;Wen-Hwa Lee

  • Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.

    Phang Lang Chen;Daniel J. Riley;Yumay Chen;Wen Hwa Lee

  • Expression and amplification of the N-myc gene in primary retinoblastoma

    W H Lee;W H Lee;A L Murphree;W F Benedict

  • The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

    Phang Lang Chen;Chi Fen Chen;Yumay Chen;Jun Xiao

  • Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

    Robert Bookstein;Pascale Rio;Steven A. Madreperla;Frank Hong

  • Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

    Bei Shan;Xueliang Zhu;Phang Lang Chen;Tim Durfee

Frequent Co-Authors

Eva Y.-H. P. Lee
Eva Y.-H. P. Lee University of California, Irvine
Phang Lang Chen
Phang Lang Chen University of California, Irvine
Yung-Ming Jeng
Yung-Ming Jeng National Taiwan University
Lucia R. Languino
Lucia R. Languino Thomas Jefferson University
Steven M. Dubinett
Steven M. Dubinett University of California, Los Angeles
A. Richard Chamberlin
A. Richard Chamberlin University of California, Irvine
C. Kent Osborne
C. Kent Osborne Baylor College of Medicine
Teresa L. Yang-Feng
Teresa L. Yang-Feng Yale University
Larry A. Donoso
Larry A. Donoso Wills Eye Hospital
Chia-Yang Liu
Chia-Yang Liu Indiana University

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