D-Index & Metrics Best Publications
Genetics and Molecular Biology
Taiwan
2022

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 79 Citations 31,162 158 World Ranking 1027 National Ranking 3

Research.com Recognitions

Awards & Achievements

2022 - Research.com Genetics and Molecular Biology in Taiwan Leader Award

2018 - Fellow, The World Academy of Sciences

2014 - Fellow, National Academy of Inventors

2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

Wen-Hwa Lee mainly focuses on Molecular biology, Cancer research, Retinoblastoma protein, Retinoblastoma and Cell biology. The various areas that he examines in his Molecular biology study include Regulation of gene expression, Gene, Exon, Cyclin D1 and Gene product. He combines subjects such as DNA damage, Carcinogenesis, Stem-cell therapy, Metastasis and Breast cancer with his study of Cancer research.

He has researched Retinoblastoma protein in several fields, including CDC2 Protein Kinase, Cyclin-dependent kinase 2 and Kinase activity. His Retinoblastoma research incorporates themes from Monoclonal antibody and SV40 large T antigen, Transfection. His Cell biology research integrates issues from CD44 and Programmed cell death.

His most cited work include:

  • The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. (1339 citations)
  • SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene (1207 citations)
  • Human retinoblastoma susceptibility gene: cloning, identification, and sequence (1202 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Molecular biology, Cancer research, Gene, Cell biology and Retinoblastoma. His research in Molecular biology intersects with topics in Gene expression, Retinoblastoma protein, Exon, Cyclin D1 and Nuclear protein. The Cancer research study combines topics in areas such as Cancer, Cancer cell, Carcinogenesis, Metastasis and Breast cancer.

Genetics covers Wen-Hwa Lee research in Gene. His Cell biology research is multidisciplinary, relying on both Oxidative stress, Biochemistry, Programmed cell death and Kinetochore. The study incorporates disciplines such as Susceptibility gene, Allele, Tumor suppressor gene, Regulation of gene expression and Antibody in addition to Retinoblastoma.

He most often published in these fields:

  • Molecular biology (34.93%)
  • Cancer research (42.47%)
  • Gene (22.26%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cancer research (42.47%)
  • Pancreatic cancer (10.96%)
  • Cancer cell (14.38%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cancer research, Pancreatic cancer, Cancer cell, Metastasis and Cancer. His studies in Cancer research integrate themes in fields like Carcinogenesis, Tumor microenvironment, Phosphorylation, Tumor progression and Kinase. His studies deal with areas such as Cell culture, Malignancy, Cell growth, Immunology and Small molecule as well as Cancer cell.

Wen-Hwa Lee interconnects Antibody and Bioinformatics in the investigation of issues within Cancer. His work deals with themes such as Molecular biology and Cell biology, which intersect with Helicase. His Molecular biology study incorporates themes from Genome instability and Homologous recombination.

Between 2013 and 2021, his most popular works were:

  • CtIP-mediated resection is essential for viability and can operate independently of BRCA1 (87 citations)
  • Targeting IL-17B–IL-17RB signaling with an anti–IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines (81 citations)
  • Targeting IL-17B–IL-17RB signaling with an anti–IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines (81 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

Wen-Hwa Lee spends much of his time researching Cancer research, Metastasis, Circulating tumor cell, Pancreatic cancer and Cancer. His Cancer research research incorporates themes from Epithelial–mesenchymal transition, Tumor progression, Immunology and Cancer cell. The concepts of his Epithelial–mesenchymal transition study are interwoven with issues in Tumor microenvironment, Cell cycle, Stromal cell and CD44.

The study incorporates disciplines such as Molecular biology and Epigenetics in addition to Metastasis. His study on Circulating tumor cell also encompasses disciplines like

  • Pathology and related Ex vivo, Internal medicine and Pancreatic ductal adenocarcinoma,
  • Prospective cohort study, which have a strong connection to Oncology, Progression-free survival, Epithelial cell adhesion molecule and Carcinoma. His Cancer research is multidisciplinary, incorporating perspectives in Whole blood, Antibody and Antigen.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

T. Durfee;K. Becherer;Phang-Lang Chen;Shiou-Hwei Yeh.
Genes & Development (1993)

2159 Citations

Human retinoblastoma susceptibility gene: cloning, identification, and sequence

Wen-Hwa Lee;Robert Bookstein;Frank Hong;Lih-Jiuan Young.
Science (1987)

1931 Citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

James A. DeCaprio;John W. Ludlow;James Figge;Jin-Yuh Shew.
Cell (1988)

1889 Citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

Eva Y.-H. P. Lee;Chi-Yao Chang;Nanpin Hu;Yi-Chun J. Wang.
Nature (1992)

1516 Citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.

Phang-Lang Chen;Peter Scully;Jin-Yuh Shew;Jean Y.J. Wang.
Cell (1989)

1311 Citations

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

Huei-Jen Su Huang;Jiing-Kuan Yee;Jin-Yuh Shew;Phang-Lang Chen.
Science (1988)

1131 Citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

David W. Goodrich;Nan Ping Wang;Yue-Wei Qian;Eva Y.-H.P. Lee.
Cell (1991)

909 Citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

Wen-Hwa Lee;Jin-Yuh Shew;Frank D. Hong;Theodore W. Sery.
Nature (1987)

879 Citations

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene

Robert Bookstein;Jin-Yuh Shew;Phang-Lang Chen;Peter Scully.
Science (1990)

827 Citations

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

Qing Zhong;Chi Fen Chen;Shang Li;Yumay Chen.
Science (1999)

808 Citations

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