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Chemistry

D-Index
51
Citations
9598
World Ranking
13920
National Ranking
3607

Overview

A. Richard Chamberlin is affiliated with the University of California, Irvine in the United States. Their research primarily spans the broader domain of Biochemistry, Genetics, and Molecular Biology, with a focus on several specialized subfields including Molecular Biology, Biophysics, Materials Chemistry, Cellular and Molecular Neuroscience, and Plant Science.

Their recent scholarly output includes publications in a range of scientific journals. Notable papers are:

  • "Regulation of mRNA translation by a photoriboswitch," published in 2020 in eLife
  • "DOTAP: Structure, hydration, and the counterion effect," published in 2023 in the Biophysical Journal
  • "Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I," published in 2020 in ChemMedChem

Research topics frequently addressed by Chamberlin include:

  • RNA Interference and Gene Delivery
  • Lipid Membrane Structure and Behavior
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Photochromic and Fluorescence Chemistry
  • Photoreceptor and Optogenetics Research
  • Light Effects on Plants
  • Beetle Biology and Toxicology Studies

Their work has been disseminated through several publication venues, with representation in journals such as the Biophysical Journal, eLife, and ChemMedChem.

Collaboration is a noted aspect of their research approach, with frequent co-authors including Mihaela Mihailescu, David L. Worcester, Christopher L. Carroll, Stephen H. White, and Kelly A. Rotstan.

Best Publications

  • Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides.

    John M. Humphrey† and;A. Richard Chamberlin

  • Increasing rates of reaction: microwave-assisted organic synthesis for combinatorial chemistry.

    Amy Lew;Peter O Krutzik;Matthew E Hart;A Richard Chamberlin

  • Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide

    J. D. Bain;Edward S. Diala;Charles G. Glabe;Thomas A. Dix

  • Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer.

    R. J. Bridges;M. S. Stanley;M. W. Anderson;C. W. Cotman

  • Congener-independent immunoassay for microcystins and nodularins

    Werner Jürgen Fischer;Ian Garthwaite;Christopher O. Miles;Kathryn Marie Ross

  • Vinyllithium reagents from arenesulfonylhydrazones

    A. Richard Chamberlin;Jeffrey E. Stemke;F. Thomas Bond

  • Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

    Christopher D. Wassman;Roberta Baronio;Özlem Demir;Özlem Demir;Brad D. Wallentine

  • Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins.

    James E. Sheppeck;Carla-Maria Gauss;A.Richard Chamberlin

  • Modeling chemical reactivity. 7. The effect of a change in rate-limiting step on the stereoselectivity of electrophilic addition to allylic alcohols and related chiral alkenes

    A. Richard Chamberlin;Robert L. Mulholland;Scott D. Kahn;Warren J. Hehre

  • Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.

    Naoe Okamura;Stephen A. Habay;Joanne Zeng;A. Richard Chamberlin

  • Enantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetals

    Stacie S. Canan Koch;A. Richard Chamberlin

  • Total Synthesis of Maytansine

    E. J. Corey;Leland O. Weigel;A. Richard Chamberlin;Hidetsura Cho

  • Modeling chemical reactivity. 4. Regiochemistry and stereochemistry of electrophilic additions to allylic double bonds

    S. D. Kahn;C. F. Pau;A. R. Chamberlin;W. J. Hehre

  • Iodocyclization of allylic alcohol derivatives containing internal nucleophiles. Control of stereoselectivity by substituents in the acyclic precursors

    A. Richard Chamberlin;Milana Dezube;Patrick Dussault;Mark C. McMills

  • Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

    Matthew E Hart;A Richard Chamberlin;Cecilia Walkom;Jennette A Sakoff

  • Synthesis of optically active pyrrolizidinediols: (+)-heliotridine

    A. Richard Chamberlin;John Y. L. Chung

  • Total Synthesis of the Serine-Threonine Phosphatase Inhibitor Microcystin-LA

    John M. Humphrey;and James B. Aggen;A. Richard Chamberlin

  • A central strategy for converting natural products into fluorescent probes.

    Matthew D. Alexander;Michael D. Burkart;Michael S. Leonard;Padma Portonovo

  • Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.

    Parminder Kaur;A. Richard Chamberlin;Thomas L. Poulos;Irina F. Sevrioukova

  • 2,3-Pyrrolidinedicarboxylates as Neurotransmitter Conformer Mimics: Enantioselective Synthesis via Chelation-Controlled Enolate Alkylation

    John M. Humphrey;Richard J. Bridges;Jill A. Hart;A. Richard Chamberlin

  • A Pharmacological Review of Competitive Inhibitors and Substrates of High-Affinity, Sodium-Dependent Glutamate Transport in the Central Nervous System

    Richard J. Bridges;Michael P. Kavanaugh;A. Richard Chamberlin

Frequent Co-Authors

Ricardo Miledi
Ricardo Miledi University of California, Irvine
Michael P. Kavanaugh
Michael P. Kavanaugh University of Montana
Wen-Hwa Lee
Wen-Hwa Lee Academia Sinica
Carl W. Cotman
Carl W. Cotman University of California, Irvine
Angus C. Nairn
Angus C. Nairn Yale University
E. J. Corey
E. J. Corey Harvard University
Phang Lang Chen
Phang Lang Chen University of California, Irvine
William Fenical
William Fenical University of California, San Diego
Amy Arai
Amy Arai Southern Illinois University School of Medicine
Robert Steele
Robert Steele University of California, Irvine

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