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Ayman El-Faham

Ayman El-Faham

Alexandria University
Egypt

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Enzyme
  • Catalysis

Ayman El-Faham mainly investigates Organic chemistry, Peptide, Peptide synthesis, Combinatorial chemistry and Reagent. Ayman El-Faham usually deals with Organic chemistry and limits it to topics linked to Solid-phase synthesis and Green chemistry. His research in Peptide intersects with topics in Coupling, Stereochemistry and Base.

The Peptide synthesis study combines topics in areas such as Solvent, Phase, Racemization, Pentapeptide repeat and Peptide bond. Ayman El-Faham has researched Combinatorial chemistry in several fields, including Amino acid, Drug delivery, Polymer, Benzidine and Piperazine. His research integrates issues of Salt, Reactivity, Acylation and Phosphonium in his study of Reagent.

His most cited work include:

  • Peptide coupling reagents, more than a letter soup (543 citations)
  • Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis (261 citations)
  • Oxyma: An Efficient Additive for Peptide Synthesis to Replace the Benzotriazole‐Based HOBt and HOAt with a Lower Risk of Explosion[1] (231 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Organic chemistry, Combinatorial chemistry, Peptide, Reagent and Stereochemistry. He has included themes like Amino acid, Peptide synthesis and Solid-phase synthesis in his Organic chemistry study. In his research on the topic of Peptide synthesis, Solvent is strongly related with Racemization.

Moiety, Molecule, Medicinal chemistry, Crystallography and Schiff base is closely connected to Triazine in his research, which is encompassed under the umbrella topic of Combinatorial chemistry. His studies in Peptide integrate themes in fields like Coupling reagent, Chloride, Coupling reaction and Amide. His research in Stereochemistry focuses on subjects like Biological activity, which are connected to Antimicrobial.

He most often published in these fields:

  • Organic chemistry (48.08%)
  • Combinatorial chemistry (32.14%)
  • Peptide (27.20%)

What were the highlights of his more recent work (between 2018-2021)?

  • Triazine (25.55%)
  • Ligand (20.33%)
  • Medicinal chemistry (19.51%)

In recent papers he was focusing on the following fields of study:

Ayman El-Faham focuses on Triazine, Ligand, Medicinal chemistry, Combinatorial chemistry and Crystallography. His Triazine research is multidisciplinary, relying on both Schiff base, Moiety, Stereochemistry, Chemical engineering and Nucleophile. His Ligand research is multidisciplinary, incorporating perspectives in Hydrogen bond and Atoms in molecules.

His Combinatorial chemistry research includes elements of Peptide bond, Peptide, Peptide synthesis and Chemoselectivity. The concepts of his Peptide synthesis study are interwoven with issues in Racemization and Solid-phase synthesis. Solvent is a primary field of his research addressed under Organic chemistry.

Between 2018 and 2021, his most popular works were:

  • Green Transformation of Solid-Phase Peptide Synthesis (30 citations)
  • Green Transformation of Solid-Phase Peptide Synthesis (30 citations)
  • Eco-friendly method for silver nanoparticles immobilized decorated silica: Synthesis & characterization and preliminary antibacterial activity (18 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Enzyme
  • Catalysis

Ayman El-Faham spends much of his time researching Ligand, Pincer movement, Molecule, Triazine and Hydrogen bond. His Triazine study integrates concerns from other disciplines, such as Schiff base, Moiety, Stereochemistry, Substituent and Piperidine. His work deals with themes such as Receptor and Biochemistry, which intersect with Moiety.

The concepts of his Hydrogen bond study are interwoven with issues in Crystallography, Stacking and Atoms in molecules. His study on Pincer ligand is mostly dedicated to connecting different topics, such as Medicinal chemistry. His Medicinal chemistry research includes elements of 1,3,5-Triazine, Zinc, Single crystal and Chloride.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Peptide coupling reagents, more than a letter soup

Ayman El-Faham;Fernando Albericio.
Chemical Reviews (2011)

1057 Citations

Oxyma: An Efficient Additive for Peptide Synthesis to Replace the Benzotriazole‐Based HOBt and HOAt with a Lower Risk of Explosion[1]

Ramon Subirós-Funosas;Rafel Prohens;Rafael Barbas;Ayman El-Faham;Ayman El-Faham.
Chemistry: A European Journal (2009)

403 Citations

Use of Onium Salt-Based Coupling Reagents in Peptide Synthesis1

Fernando Albericio;Josep M. Bofill;Ayman El-Faham;Steven A. Kates.
Journal of Organic Chemistry (1998)

374 Citations

Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis

Louis A. Carpino;Ayman El-Faham;Charles A. Minor;Fernando Albericio.
Journal of The Chemical Society, Chemical Communications (1994)

352 Citations

Green Solid-Phase Peptide Synthesis 2. 2-Methyltetrahydrofuran and Ethyl Acetate for Solid-Phase Peptide Synthesis under Green Conditions

Yahya E. Jad;Gerardo A. Acosta;Thavendran Govender;Hendrik G. Kruger.
ACS Sustainable Chemistry & Engineering (2016)

352 Citations

Tetramethylfluoroformamidinium Hexafluorophosphate: A Rapid-Acting Peptide Coupling Reagent for Solution and Solid Phase Peptide Synthesis

Louis A. Carpino;Ayman El-Faham.
Journal of the American Chemical Society (1995)

349 Citations

Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents

Louis A. Carpino;Ayman El-Faham;Fernando Albericio.
Tetrahedron Letters (1994)

339 Citations

The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.

Louis A. Carpino;Hideko Imazumi;Ayman El-Faham;Fernando J. Ferrer.
Angewandte Chemie (2002)

339 Citations

COMU: A Safer and More Effective Replacement for Benzotriazole‐Based Uronium Coupling Reagents

Ayman El-Faham;Ayman El-Faham;Ramon Subirós Funosas;Rafel Prohens;Fernando Albericio.
Chemistry: A European Journal (2009)

321 Citations

EFFICIENCY IN PEPTIDE COUPLING : 1-HYDROXY-7-AZABENZOTRIAZOLE VS 3,4-DIHYDRO-3-HYDROXY-4-OXO-1,2,3-BENZOTRIAZINE

Louis A. Carpino;Ayman El-Faham;Fernando Albericio.
Journal of Organic Chemistry (1995)

277 Citations

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