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Neuroscience

D-Index
53
Citations
12648
World Ranking
5048
National Ranking
2263

Overview

Rainer K. Reinscheid is affiliated with the University of California, Irvine in the United States. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a focus on molecular and cellular mechanisms within these areas.

The main topics addressed in their work include:

  • Neuropeptides and Animal Physiology
  • Receptor Mechanisms and Signaling
  • Sleep and Wakefulness Research
  • Regulation of Appetite and Obesity
  • Monoclonal and Polyclonal Antibodies Research
  • Mass Spectrometry Techniques and Applications
  • Pharmacological Effects and Assays

Subfields of study featured prominently in their publications are:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Endocrine and Autonomic Systems
  • Radiology, Nuclear Medicine and Imaging

Rainer K. Reinscheid has contributed to several scientific journals, including multiple papers in:

  • Communications Biology
  • Pharmaceuticals
  • European Journal of Pharmacology
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Peptides

Among recent publications are:

  • A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening, 2022, Communications Biology
  • Pharmacology, Physiology and Genetics of the Neuropeptide S System, 2021, Pharmaceuticals
  • HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants, 2021, Communications Biology
  • Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality, 2021, Peptides
  • Structure-Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity, 2021, Journal of Medicinal Chemistry

Frequent collaborators in their research include:

  • Stefan Schulz
  • Pooja Dasgupta
  • Chiara Ruzza
  • Girolamo Calò
  • Nina Kathleen Blum

Best Publications

  • Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

    Rainer K. Reinscheid;Hans Peter Nothacker;Anne Bourson;Ali Ardati

  • Neuropeptide S: A Neuropeptide Promoting Arousal and Anxiolytic-like Effects

    Yan Ling Xu;Rainer K. Reinscheid;Salvador Huitron-Resendiz;Stewart D. Clark

  • Orphanin FQ is a functional anti-opioid peptide

    J.S Mogil;J.E Grisel;R.K Reinscheid;O Civelli

  • Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.

    Francois Jenck;Jean-Luc Moreau;James R. Martin;Gavin J. Kilpatrick

  • Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat.

    Charles R. Neal;Alfred Mansour;Rainer Reinscheid;Hans Peter Nothacker

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding.

    Charles R. Neal;Charles R. Neal;Alfred Mansour;Rainer Reinscheid;Hans Peter Nothacker

  • The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

    Unknown

  • Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.

    Kay Jüngling;Thomas Seidenbecher;Ludmila Sosulina;Jörg Lesting

  • Primary structure and tissue distribution of the orphanin FQ precursor.

    Hans Peter Nothacker;Rainer K. Reinscheid;Alfred Mansour;Robert A. Henningsen

  • Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain.

    Yan-Ling Xu;Christine M. Gall;Valerie R. Jackson;Olivier Civelli

  • Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

    Anja Köster;Alexandra Montkowski;Stefan Schulz;Eva-Maria Stübe

  • Structure-activity relationship studies on the novel neuropeptide orphanin FQ.

    Rainer K. Reinscheid;Ali Ardati;Frederick J. Monsma;Olivier Civelli

  • Pharmacological Characterization of Human and Murine Neuropeptide S Receptor Variants

    Rainer K. Reinscheid;Yan-Ling Xu;Naoe Okamura;Joanne Zeng

  • Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist

    Hans Peter Nothacker;Zhiwei Wang;Yuhong Zhu;Rainer K. Reinscheid

  • G protein-coupled receptor deorphanizations.

    Olivier Civelli;Rainer K. Reinscheid;Yan Zhang;Zhiwei Wang

  • Modulation of Voltage-Gated Calcium Channels by Orphanin FQ in Freshly Dissociated Hippocampal Neurons

    Frederic Knoflach;Rainer K. Reinscheid;Olivier Civelli;John A. Kemp

  • Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors

    Olivier Civelli;Hans Peter Nothacker;Yumiko Saito;Zhiwei Wang

  • Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.

    Naoe Okamura;Stephen A. Habay;Joanne Zeng;A. Richard Chamberlin

  • The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion

    Darragh P. Devine;Rainer K. Reinscheid;Frederick J. Monsma;Olivier Civelli

  • Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain

    Naoe Okamura;Celia Garau;Dee M Duangdao;Stewart D Clark

  • Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala

    K. Jüngling;T. Seidenbecher;L. Sosulina;J. Lesting

Frequent Co-Authors

Olivier Civelli
Olivier Civelli University of California, Irvine
Hans-Christian Pape
Hans-Christian Pape University of Münster
Huda Akil
Huda Akil University of Michigan–Ann Arbor
Stanley J. Watson
Stanley J. Watson University of Michigan–Ann Arbor
Michele Simonato
Michele Simonato University of Ferrara
Thomas Seidenbecher
Thomas Seidenbecher University of Münster
David K. Grandy
David K. Grandy Oregon Health & Science University
Alfred Mansour
Alfred Mansour University of Michigan–Ann Arbor
Falk Kiefer
Falk Kiefer Heidelberg University
Steven J. Henriksen
Steven J. Henriksen Scripps Research Institute

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