World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
110
Citations
40586
World Ranking
544
National Ranking
310

Medicine

D-Index
111
Citations
40805
World Ranking
5371
National Ranking
2897

Overview

Gavril W. Pasternak was affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focused on fields within Biochemistry, Genetics and Molecular Biology, as well as Neuroscience, contributing 12 and 8 publications respectively. Subfields of study that featured prominently in their work included Molecular Biology, Cellular and Molecular Neuroscience, Pharmacology, Biochemistry, and Organic Chemistry.

The scientist's work addressed several main topics including Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Pharmacological Receptor Mechanisms and Effects, Alkaloids: synthesis and pharmacology, Traditional and Medicinal Uses of Annonaceae, Chemical synthesis and alkaloids, and Nerve injury and regeneration.

Frequent publication venues for Pasternak included:

  • Cellular and Molecular Neurobiology
  • ACS Chemical Neuroscience
  • eLife
  • Journal of Medicinal Chemistry
  • Cell stem cell

Their recent notable publications comprised:

  • "Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site," 2021, eLife
  • "Oxidative Metabolism as a Modulator of Kratom's Biological Actions," 2021, Journal of Medicinal Chemistry
  • "Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy," 2023, Cell stem cell
  • "Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom," 2021, ACS Chemical Neuroscience
  • "Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1," 2020, Cellular and Molecular Neurobiology

The scientist collaborated frequently with several coauthors, including Amanda Hunkele, Ying-Xian Pan, Rajendra Uprety, Susruta Majumdar, and András Váradi.

Best Publications

  • Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

    Roger Chou;Gilbert J. Fanciullo;Perry G. Fine;Jeremy A. Adler

  • Strategies to Manage the Adverse Effects of Oral Morphine: An Evidence-Based Report

    Nathan Cherny;Carla Ripamonti;Jose Pereira;Carol Davis

  • Pharmacological mechanisms of opioid analgesics.

    Gavril W. Pasternak

  • Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

    Candace B. Pert;Gavril Pasternak;Solomon H. Snyder

  • Mu Opioids and Their Receptors: Evolution of a Concept

    Gavril W. Pasternak;Ying Xian Pan

  • The Molecular and Behavioral Pharmacology of the Orphanin FQ/Nociceptin Peptide and Receptor Family

    Jeffrey S. Mogil;Gavril W. Pasternak

  • Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

    Yanxin Zhu;Michael A. King;Alwin G.P. Schuller;Joshua F. Nitsche

  • Classification of multiple morphine and enkephalin binding sites in the central nervous system

    Benjamen L. Wolozin;Gavril W. Pasternak

  • Minireview: Multiple MU opiate receptors

    Gavril W. Pasternak;Paul J. Wood

  • An endogenous morphine-like factor in mammalian brain.

    Gavril W. Pasternak;Robert Goodman;Solomon H. Snyder

  • Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

    D Paul;K M Standifer;C E Inturrisi;G W Pasternak

  • Morphine-6-glucuronide, a potent mu agonist

    Gavril W. Pasternak;Richard J. Bodnar;Richard J. Bodnar;Janet A. Clark;Charles E. Inturrisi;Charles E. Inturrisi

  • Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.

    Alwin G.P. Schuller;Michael A. King;Jiwen Zhang;Elizabeth Bolan

  • Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.

    J A Clark;L Liu;M Price;B Hersh

  • The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.

    Kathryn Elliott;Nobuko Minami;Yuri A. Kolesnikov;Gavril W. Pasternak;Gavril W. Pasternak

  • Separation of Opioid Analgesia from Respiratory Depression: Evidence for Different Receptor Mechanisms

    G. S. F. Ling;K. Spiegel;S. H. Lockhart;G. W. Pasternak

  • Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

    Tao Che;Susruta Majumdar;Saheem A. Zaidi;Pauline Ondachi

  • Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists.

    Pasternak Gw;Wilson Ha;Snyder Sh

  • Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

    Gavril W. Pasternak;Stephen R. Childers;Solomon H. Snyder

  • Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

    Yuri A. Kolesnikov;Chaim G. Pick;Grazyna Ciszewska;Gavril W. Pasternak

Frequent Co-Authors

Grace C. Rossi
Grace C. Rossi Long Island University
Richard J. Bodnar
Richard J. Bodnar Queens College, CUNY
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
John E. Pintar
John E. Pintar Rutgers, The State University of New Jersey
Chaim G. Pick
Chaim G. Pick Tel Aviv University
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill
Jonathan A. Javitch
Jonathan A. Javitch Columbia University
Urs Rutishauser
Urs Rutishauser Memorial Sloan Kettering Cancer Center
Xi Ping Huang
Xi Ping Huang University of North Carolina at Chapel Hill
Ellen M. Unterwald
Ellen M. Unterwald Temple University

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