World's Best Scientists 2026 revealed!
Hiroshi Nagase

Hiroshi Nagase

D-Index & Metrics

Chemistry

D-Index
62
Citations
13148
World Ranking
8858
National Ranking
613

Hiroshi Nagase publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Hiroshi Nagase sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 453 publications — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Hiroshi Nagase D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Hiroshi Nagase sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 62 D-Index — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Hiroshi Nagase is affiliated with the University of Tsukuba in Japan. Their research spans multiple areas within neuroscience and biochemistry, genetics, and molecular biology, with a particular focus on cellular and molecular neuroscience, molecular biology, cognitive neuroscience, behavioral neuroscience, and materials chemistry.

The scientist has contributed extensively to research on neuropeptides and animal physiology, receptor mechanisms and signaling, pharmacological receptor mechanisms and effects, stress responses and cortisol, sleep and wakefulness research, neuroscience and neuropharmacology research, and cancer, stress, anesthesia, and immune response.

Some recent papers authored or co-authored by Nagase include:

  • Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors, 2021, Cell Reports
  • Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice, 2021, Biochemical and Biophysical Research Communications
  • Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses, 2021, Frontiers in Immunology
  • Design and Synthesis of Orexin 1 Receptor-Selective Agonists, 2023, Journal of Medicinal Chemistry
  • OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy, 2022, PLoS ONE

Frequent co-authors collaborating with Nagase include:

  • Tsuyoshi Saitoh
  • Daisuke Yamada
  • Keita Iio
  • Yasuyuki Nagumo
  • Noriki Kutsumura

The scientist publishes regularly in several venues, with multiple contributions to the Proceedings for Annual Meeting of The Japanese Pharmacological Society, and articles in Bioorganic & Medicinal Chemistry Letters, Nature Communications, The Cambridge Structural Database, and Cell Reports.

Best Publications

  • Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

    Adam P. Kardon;Erika Polgár;Junichi Hachisuka;Lindsey M. Snyder

  • Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

    Philip S Portoghese;M. Sultana;H. Nagase;A. E. Takemori

  • In silico design of novel probes for the atypical opioid receptor MRGPRX2

    Katherine Lansu;Joel Karpiak;Jing Liu;Xi Ping Huang

  • Antipruritic activity of the κ-opioid receptor agonist, TRK-820

    Yuko Togashi;Hideo Umeuchi;Kiyoshi Okano;Naoki Ando

  • Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

    Akiyoshi Saitoh;Yuji Kimura;Tomohiko Suzuki;Koji Kawai

  • A highly selective δ1-opioid receptor antagonist : 7-benzylidenenaltrexone

    P.S. Portoghese;M. Sultana;H. Nagase;A.E. Takemori

  • DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN

    Hiroshi Nagase;Jun Hayakawa;Kuniaki Kawamura;Kouji Kawai

  • Blockade of morphine reward through the activation of κ-opioid receptors in mice

    Masahiko Funada;Tsutomu Suzuki;Minoru Narita;Miwa Misawa

  • The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

    Tsutomu Suzuki;Yoshinao Shiozaki;Yoshikazu Masukawa;Miwa Misawa

  • Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.

    Leon F. Tseng;Minoru Narita;Chiaki Suganuma;Hirokazu Mizoguchi

  • Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

    Ryan M. Fryer;Anna K. Hsu;Hiroshi Nagase;Garrett J. Gross

  • Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

    Hideo Umeuchi;Yuko Togashi;Toshiyuki Honda;Kaoru Nakao

  • Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

    Philip S Portoghese;H. Nagase;A. W. Lipkowski;D. L. Larson

  • Involvement of the opioid system in the anxiolytic effect of diazepam in mice

    Makoto Tsuda;Tsutomu Suzuki;Miwa Misawa;Hiroshi Nagase

  • Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

    Yoko Irukayama-Tomobe;Yasuhiro Ogawa;Hiromu Tominaga;Yukiko Ishikawa

  • Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.

    P. S. Portoghese;H. Nagase;K. E. MaloneyHuss;C. E. Lin

  • Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

    Takashi Endoh;Hirotoshi Matsuura;Atsushi Tajima;Naoki Izumimoto

  • Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

    Tsutomu Suzuki;Masahiko Funada;Minoru Narita;Miwa Misawa

  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

    Takashi Nagahara;Tsuyoshi Saitoh;Noriki Kutsumura;Yoko Irukayama-Tomobe

  • Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

    N. Hirose;K. Murakawa;K. Takada;Y. Oi

Frequent Co-Authors

Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo
Minoru Narita
Minoru Narita Hoshi University
Masashi Yanagisawa
Masashi Yanagisawa University of Tsukuba
Michiko Narita
Michiko Narita Tokyo Medical University
Henry I. Yamamura
Henry I. Yamamura University of Arizona
Hisao Nishiyama
Hisao Nishiyama Nagoya University
Victor J. Hruby
Victor J. Hruby University of Arizona
Yoshimasa Hirata
Yoshimasa Hirata Meijo University
Kiyoyuki Yamada
Kiyoyuki Yamada Nagoya University
Makoto Tsuda
Makoto Tsuda Kyushu University

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