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Hiroshi Nagase

Hiroshi Nagase

D-Index & Metrics

Chemistry

D-Index
62
Citations
13148
World Ranking
8860
National Ranking
613

Overview

Hiroshi Nagase is affiliated with the University of Tsukuba in Japan. Their research spans multiple areas within neuroscience and biochemistry, genetics, and molecular biology, with a particular focus on cellular and molecular neuroscience, molecular biology, cognitive neuroscience, behavioral neuroscience, and materials chemistry.

The scientist has contributed extensively to research on neuropeptides and animal physiology, receptor mechanisms and signaling, pharmacological receptor mechanisms and effects, stress responses and cortisol, sleep and wakefulness research, neuroscience and neuropharmacology research, and cancer, stress, anesthesia, and immune response.

Some recent papers authored or co-authored by Nagase include:

  • Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors, 2021, Cell Reports
  • Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice, 2021, Biochemical and Biophysical Research Communications
  • Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses, 2021, Frontiers in Immunology
  • Design and Synthesis of Orexin 1 Receptor-Selective Agonists, 2023, Journal of Medicinal Chemistry
  • OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy, 2022, PLoS ONE

Frequent co-authors collaborating with Nagase include:

  • Tsuyoshi Saitoh
  • Daisuke Yamada
  • Keita Iio
  • Yasuyuki Nagumo
  • Noriki Kutsumura

The scientist publishes regularly in several venues, with multiple contributions to the Proceedings for Annual Meeting of The Japanese Pharmacological Society, and articles in Bioorganic & Medicinal Chemistry Letters, Nature Communications, The Cambridge Structural Database, and Cell Reports.

Best Publications

  • Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

    Adam P. Kardon;Erika Polgár;Junichi Hachisuka;Lindsey M. Snyder

  • Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

    Philip S Portoghese;M. Sultana;H. Nagase;A. E. Takemori

  • In silico design of novel probes for the atypical opioid receptor MRGPRX2

    Katherine Lansu;Joel Karpiak;Jing Liu;Xi Ping Huang

  • Antipruritic activity of the κ-opioid receptor agonist, TRK-820

    Yuko Togashi;Hideo Umeuchi;Kiyoshi Okano;Naoki Ando

  • Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

    Akiyoshi Saitoh;Yuji Kimura;Tomohiko Suzuki;Koji Kawai

  • A highly selective δ1-opioid receptor antagonist : 7-benzylidenenaltrexone

    P.S. Portoghese;M. Sultana;H. Nagase;A.E. Takemori

  • DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN

    Hiroshi Nagase;Jun Hayakawa;Kuniaki Kawamura;Kouji Kawai

  • Blockade of morphine reward through the activation of κ-opioid receptors in mice

    Masahiko Funada;Tsutomu Suzuki;Minoru Narita;Miwa Misawa

  • The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

    Tsutomu Suzuki;Yoshinao Shiozaki;Yoshikazu Masukawa;Miwa Misawa

  • Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.

    Leon F. Tseng;Minoru Narita;Chiaki Suganuma;Hirokazu Mizoguchi

  • Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

    Ryan M. Fryer;Anna K. Hsu;Hiroshi Nagase;Garrett J. Gross

  • Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

    Hideo Umeuchi;Yuko Togashi;Toshiyuki Honda;Kaoru Nakao

  • Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

    Philip S Portoghese;H. Nagase;A. W. Lipkowski;D. L. Larson

  • Involvement of the opioid system in the anxiolytic effect of diazepam in mice

    Makoto Tsuda;Tsutomu Suzuki;Miwa Misawa;Hiroshi Nagase

  • Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

    Yoko Irukayama-Tomobe;Yasuhiro Ogawa;Hiromu Tominaga;Yukiko Ishikawa

  • Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.

    P. S. Portoghese;H. Nagase;K. E. MaloneyHuss;C. E. Lin

  • Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

    Takashi Endoh;Hirotoshi Matsuura;Atsushi Tajima;Naoki Izumimoto

  • Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

    Tsutomu Suzuki;Masahiko Funada;Minoru Narita;Miwa Misawa

  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

    Takashi Nagahara;Tsuyoshi Saitoh;Noriki Kutsumura;Yoko Irukayama-Tomobe

  • Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

    N. Hirose;K. Murakawa;K. Takada;Y. Oi

Frequent Co-Authors

Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo
Minoru Narita
Minoru Narita Hoshi University
Masashi Yanagisawa
Masashi Yanagisawa University of Tsukuba
Michiko Narita
Michiko Narita Tokyo Medical University
Henry I. Yamamura
Henry I. Yamamura University of Arizona
Hisao Nishiyama
Hisao Nishiyama Nagoya University
Victor J. Hruby
Victor J. Hruby University of Arizona
Yoshimasa Hirata
Yoshimasa Hirata Meijo University
Kiyoyuki Yamada
Kiyoyuki Yamada Nagoya University
Makoto Tsuda
Makoto Tsuda Kyushu University

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