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Hiroshi Nagase

Hiroshi Nagase

University of Tsukuba
Japan

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 62 8858 8035 613 570 453 13148

Hiroshi Nagase publications per year

The chart shows the history of publications by Hiroshi Nagase between 1966 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Hiroshi Nagase published across 60 years, from 1966 to 2025, averaging 8.5 papers a year. Output peaked at 31 publications in 1994. 8 of the 510 publications appeared in the last two years.

No. of publications
10 20 30
Bar chart. Horizontal axis: year, 1966 to 2025. Vertical axis: number of publications, 0 to 31. Peak 31 publications in 1994. 1966: 2 publications 1967: 0 publications 1968: 0 publications 1969: 0 publications 1970: 0 publications 1971: 1 publication 1972: 1 publication 1973: 8 publications 1974: 8 publications 1975: 0 publications 1976: 1 publication 1977: 1 publication 1978: 1 publication 1979: 2 publications 1980: 1 publication 1981: 0 publications 1982: 0 publications 1983: 0 publications 1984: 1 publication 1985: 4 publications 1986: 2 publications 1987: 1 publication 1988: 4 publications 1989: 4 publications 1990: 8 publications 1991: 5 publications 1992: 13 publications 1993: 29 publications 1994: 31 publications 1995: 12 publications 1996: 13 publications 1997: 24 publications 1998: 21 publications 1999: 23 publications 2000: 28 publications 2001: 19 publications 2002: 9 publications 2003: 9 publications 2004: 19 publications 2005: 5 publications 2006: 9 publications 2007: 5 publications 2008: 9 publications 2009: 10 publications 2010: 12 publications 2011: 14 publications 2012: 17 publications 2013: 9 publications 2014: 12 publications 2015: 11 publications 2016: 6 publications 2017: 16 publications 2018: 11 publications 2019: 12 publications 2020: 7 publications 2021: 14 publications 2022: 11 publications 2023: 7 publications 2024: 4 publications 2025: 4 publications
1966 2025

510 publications in total across all disciplines

View publications per year as a table
Hiroshi Nagase: publications per year, 1966 to 2025
Year Publications
1966 2
1967 0
1968 0
1969 0
1970 0
1971 1
1972 1
1973 8
1974 8
1975 0
1976 1
1977 1
1978 1
1979 2
1980 1
1981 0
1982 0
1983 0
1984 1
1985 4
1986 2
1987 1
1988 4
1989 4
1990 8
1991 5
1992 13
1993 29
1994 31
1995 12
1996 13
1997 24
1998 21
1999 23
2000 28
2001 19
2002 9
2003 9
2004 19
2005 5
2006 9
2007 5
2008 9
2009 10
2010 12
2011 14
2012 17
2013 9
2014 12
2015 11
2016 6
2017 16
2018 11
2019 12
2020 7
2021 14
2022 11
2023 7
2024 4
2025 4
Total 510
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Hiroshi Nagase publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Hiroshi Nagase sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 441–460 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 453 publications — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623
121–140 918
141–160 1,218
161–180 1,350
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270 453
461–480 265
481–500 252
501–520 201
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Hiroshi Nagase D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Hiroshi Nagase sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 62–63 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 62 D-Index — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289
42–43 612
44–45 808
46–47 776
48–49 835
50–51 861
52–53 872
54–55 933
56–57 1,051
58–59 930
60–61 882
62–63 834 62
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
Download as CSV

Overview

Hiroshi Nagase is affiliated with the University of Tsukuba in Japan. Their research spans multiple areas within neuroscience and biochemistry, genetics, and molecular biology, with a particular focus on cellular and molecular neuroscience, molecular biology, cognitive neuroscience, behavioral neuroscience, and materials chemistry.

The scientist has contributed extensively to research on neuropeptides and animal physiology, receptor mechanisms and signaling, pharmacological receptor mechanisms and effects, stress responses and cortisol, sleep and wakefulness research, neuroscience and neuropharmacology research, and cancer, stress, anesthesia, and immune response.

Some recent papers authored or co-authored by Nagase include:

  • Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors, 2021, Cell Reports
  • Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice, 2021, Biochemical and Biophysical Research Communications
  • Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses, 2021, Frontiers in Immunology
  • Design and Synthesis of Orexin 1 Receptor-Selective Agonists, 2023, Journal of Medicinal Chemistry
  • OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy, 2022, PLoS ONE

Frequent co-authors collaborating with Nagase include:

  • Tsuyoshi Saitoh
  • Daisuke Yamada
  • Keita Iio
  • Yasuyuki Nagumo
  • Noriki Kutsumura

The scientist publishes regularly in several venues, with multiple contributions to the Proceedings for Annual Meeting of The Japanese Pharmacological Society, and articles in Bioorganic & Medicinal Chemistry Letters, Nature Communications, The Cambridge Structural Database, and Cell Reports.

Best Publications

  • Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

    Adam P. Kardon;Erika Polgár;Junichi Hachisuka;Lindsey M. Snyder

  • Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

    Philip S Portoghese;M. Sultana;H. Nagase;A. E. Takemori

  • In silico design of novel probes for the atypical opioid receptor MRGPRX2

    Katherine Lansu;Joel Karpiak;Jing Liu;Xi Ping Huang

  • Antipruritic activity of the κ-opioid receptor agonist, TRK-820

    Yuko Togashi;Hideo Umeuchi;Kiyoshi Okano;Naoki Ando

  • Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

    Akiyoshi Saitoh;Yuji Kimura;Tomohiko Suzuki;Koji Kawai

  • A highly selective δ1-opioid receptor antagonist : 7-benzylidenenaltrexone

    P.S. Portoghese;M. Sultana;H. Nagase;A.E. Takemori

  • DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN

    Hiroshi Nagase;Jun Hayakawa;Kuniaki Kawamura;Kouji Kawai

  • Blockade of morphine reward through the activation of κ-opioid receptors in mice

    Masahiko Funada;Tsutomu Suzuki;Minoru Narita;Miwa Misawa

  • The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

    Tsutomu Suzuki;Yoshinao Shiozaki;Yoshikazu Masukawa;Miwa Misawa

  • Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.

    Leon F. Tseng;Minoru Narita;Chiaki Suganuma;Hirokazu Mizoguchi

  • Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

    Ryan M. Fryer;Anna K. Hsu;Hiroshi Nagase;Garrett J. Gross

  • Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

    Hideo Umeuchi;Yuko Togashi;Toshiyuki Honda;Kaoru Nakao

  • Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

    Philip S Portoghese;H. Nagase;A. W. Lipkowski;D. L. Larson

  • Involvement of the opioid system in the anxiolytic effect of diazepam in mice

    Makoto Tsuda;Tsutomu Suzuki;Miwa Misawa;Hiroshi Nagase

  • Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

    Yoko Irukayama-Tomobe;Yasuhiro Ogawa;Hiromu Tominaga;Yukiko Ishikawa

  • Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.

    P. S. Portoghese;H. Nagase;K. E. MaloneyHuss;C. E. Lin

  • Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

    Takashi Endoh;Hirotoshi Matsuura;Atsushi Tajima;Naoki Izumimoto

  • Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

    Tsutomu Suzuki;Masahiko Funada;Minoru Narita;Miwa Misawa

  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

    Takashi Nagahara;Tsuyoshi Saitoh;Noriki Kutsumura;Yoko Irukayama-Tomobe

  • Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

    N. Hirose;K. Murakawa;K. Takada;Y. Oi

Frequent Co-Authors

Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo
Minoru Narita
Minoru Narita Hoshi University
Masashi Yanagisawa
Masashi Yanagisawa University of Tsukuba
Michiko Narita
Michiko Narita Tokyo Medical University
Henry I. Yamamura
Henry I. Yamamura University of Arizona
Hisao Nishiyama
Hisao Nishiyama Nagoya University
Victor J. Hruby
Victor J. Hruby University of Arizona
Yoshimasa Hirata
Yoshimasa Hirata Meijo University
Kiyoyuki Yamada
Kiyoyuki Yamada Nagoya University
Makoto Tsuda
Makoto Tsuda Kyushu University

External Links

Personal website of Hiroshi Nagase

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Best Scientists Citing Hiroshi Nagase

Tsutomu Suzuki

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Publications: 110

Minoru Narita

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Hoshi University

Publications: 82

Brigitte L. Kieffer

Brigitte L. Kieffer

University of Strasbourg

Publications: 38

Abba J. Kastin

Abba J. Kastin

Louisiana State University

Publications: 31

Kenner C. Rice

Kenner C. Rice

National Institutes of Health

Publications: 30

Rafael Maldonado

Rafael Maldonado

Pompeu Fabra University

Publications: 28

Garrett J. Gross

Garrett J. Gross

Medical College of Wisconsin

Publications: 24

Michiko Narita

Michiko Narita

Tokyo Medical University

Publications: 24

Lee-Yuan Liu-Chen

Lee-Yuan Liu-Chen

Temple University

Publications: 22

Richard J. Bodnar

Richard J. Bodnar

Queens College, CUNY

Publications: 22

Géza Tóth

Géza Tóth

University of the Basque Country

Publications: 21

Philip S. Portoghese

Philip S. Portoghese

University of Minnesota

Publications: 20

Victor J. Hruby

Victor J. Hruby

University of Arizona

Publications: 19

Mary Jeanne Kreek

Mary Jeanne Kreek

Rockefeller University

Publications: 19

James H. Woods

James H. Woods

University of Michigan–Ann Arbor

Publications: 19

Shinobu Sakurada

Shinobu Sakurada

Tohoku Medical and Pharmaceutical University

Publications: 17

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