D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 49 Citations 7,486 250 World Ranking 9152 National Ranking 735

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Internal medicine
  • Agonist

Pharmacology, Agonist, Internal medicine, Receptor and Endocrinology are his primary areas of study. His study in Pharmacology is interdisciplinary in nature, drawing from both Antagonist, Naltriben and Opioid. His research in Agonist intersects with topics in Stimulus control and Analgesic, Anesthesia.

Hiroshi Nagase has included themes like Cell biology and Spinal cord in his Internal medicine study. His Receptor research incorporates elements of Wakefulness and Stimulation. His work deals with themes such as Nociceptin receptor, Molecular biology, -Naloxone and Mechanism of action, which intersect with Endocrinology.

His most cited work include:

  • Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord (198 citations)
  • Antipruritic activity of the κ-opioid receptor agonist, TRK-820 (165 citations)
  • Blockade of morphine reward through the activation of κ-opioid receptors in mice (155 citations)

What are the main themes of his work throughout his whole career to date?

Hiroshi Nagase mostly deals with Pharmacology, Agonist, Opioid receptor, Receptor and Opioid. His Pharmacology research is multidisciplinary, relying on both Naltrindole, Antagonist, δ-opioid receptor and Nociception. His work in the fields of Nalfurafine, TAN-67 and κ-opioid receptor overlaps with other areas such as Trk receptor.

Hiroshi Nagase has researched Opioid receptor in several fields, including Moiety and Drug. His work carried out in the field of Receptor brings together such families of science as Endocrinology and Stimulation. His studies in Opioid integrate themes in fields like Analgesic, Stereochemistry and Conditioned place preference.

He most often published in these fields:

  • Pharmacology (44.05%)
  • Agonist (33.81%)
  • Opioid receptor (33.57%)

What were the highlights of his more recent work (between 2012-2021)?

  • Agonist (33.81%)
  • Stereochemistry (27.38%)
  • Pharmacology (44.05%)

In recent papers he was focusing on the following fields of study:

Agonist, Stereochemistry, Pharmacology, Receptor and Opioid receptor are his primary areas of study. His Agonist research is multidisciplinary, incorporating elements of Derivative and Endocrinology. His Stereochemistry study integrates concerns from other disciplines, such as Structure–activity relationship and Nalfurafine.

His Pharmacology study combines topics in areas such as Naltrindole, Opioid antagonist, Benzodiazepine, Anxiolytic and Antagonist. His work is dedicated to discovering how Receptor, Moiety are connected with Pharmacophore, Conformational isomerism, Indole test and Propellane and other disciplines. His Opioid receptor study contributes to a more complete understanding of Opioid.

Between 2012 and 2021, his most popular works were:

  • Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord (198 citations)
  • In silico design of novel probes for the atypical opioid receptor MRGPRX2 (123 citations)
  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. (54 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Internal medicine
  • Agonist

Hiroshi Nagase spends much of his time researching Agonist, Opioid receptor, Receptor, Pharmacology and Opioid. Agonist is a subfield of Internal medicine that Hiroshi Nagase studies. His work focuses on many connections between Opioid receptor and other disciplines, such as Stereochemistry, that overlap with his field of interest in Conformational isomerism.

Many of his research projects under Receptor are closely connected to Mechanism with Mechanism, tying the diverse disciplines of science together. Hiroshi Nagase interconnects Nociception, Methylnaltrexone, Cell cycle, δ-opioid receptor and OGFr in the investigation of issues within Pharmacology. His study looks at the intersection of Opioid and topics like Benzodiazepine with Diazepam.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Antipruritic activity of the κ-opioid receptor agonist, TRK-820

Yuko Togashi;Hideo Umeuchi;Kiyoshi Okano;Naoki Ando.
European Journal of Pharmacology (2002)

255 Citations

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Adam P. Kardon;Erika Polgár;Junichi Hachisuka;Lindsey M. Snyder.
Neuron (2014)

249 Citations

Blockade of morphine reward through the activation of κ-opioid receptors in mice

Masahiko Funada;Tsutomu Suzuki;Minoru Narita;Miwa Misawa.
Neuropharmacology (1993)

237 Citations

Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

Akiyoshi Saitoh;Yuji Kimura;Tomohiko Suzuki;Koji Kawai.
Journal of Pharmacological Sciences (2004)

220 Citations

DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN

Hiroshi Nagase;Jun Hayakawa;Kuniaki Kawamura;Kouji Kawai.
Chemical & Pharmaceutical Bulletin (1998)

215 Citations

The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

Tsutomu Suzuki;Yoshinao Shiozaki;Yoshikazu Masukawa;Miwa Misawa.
Japanese Journal of Pharmacology (1992)

212 Citations

Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.

Leon F. Tseng;Minoru Narita;Chiaki Suganuma;Hirokazu Mizoguchi.
Journal of Pharmacology and Experimental Therapeutics (2000)

196 Citations

Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

Ryan M. Fryer;Anna K. Hsu;Hiroshi Nagase;Garrett J. Gross.
Journal of Pharmacology and Experimental Therapeutics (2000)

195 Citations

Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

Philip S Portoghese;H. Nagase;A. W. Lipkowski;D. L. Larson.
Journal of Medicinal Chemistry (1988)

190 Citations

Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

Hideo Umeuchi;Yuko Togashi;Toshiyuki Honda;Kaoru Nakao.
European Journal of Pharmacology (2003)

162 Citations

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